1.

Record Nr.

UNINA9910464348303321

Titolo

RNA editing : current research and future trends / / edited by Stefan Maas

Pubbl/distr/stampa

Norfolk, England : , : Caister Academic Press, , [2013]

©2013

ISBN

1-908230-88-6

Descrizione fisica

1 online resource (249 p.)

Disciplina

572.88

Soggetti

RNA editing

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographies and index.

Nota di contenuto

Contents; Contributors; Preface; Ch 01: Regulation of Ion Channel and Transporter Function Through RNA Editing; Ch 02: Mechanisms and Functions of RNA Editing in Physarum polycephalum; Ch 03: Transfer RNA Modification and Editing; Ch 04: Coordination of RNA Editing with Other RNA Processes in Kinetoplastid Mitochondria; Ch 05: Structural Studies of U-Insertion/ Deletion RNA Editing in Trypanosomes; Ch 06: RNA Editing and Small Regulatory RNAs; Ch 07: Deaminase-dependent and Deaminase-independent Functionsof APOBEC1 and APOBEC1 Complementation Factor in the Context of the APOBEC Family

Ch 08: Identification of RNA Editing Sites: a Survey of the Past, Present and FutureCh 09: Regulation of Gene Expression Through Inosine-containing Untranslated Regions; ADAR and the Balance Game Between Virus Infection and InnateImmune Cell Response; Index

Sommario/riassunto

Cellular editing of RNA can lead to the recoding of expressed sequences before they mature to their functional gene products - such as proteins or regulatory RNAs - and represents a hidden layer of genetic information and regulation. Often, the recoding events are essential for the normal function of the gene product (for example, creating an open reading frame). In other cases, RNA editing creates additional variation and phenotypic diversity since both the edited and the non-edited versions of the product are functional and co-exist. It is



necessary to understand the mechanisms of RNA editin