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Record Nr. |
UNINA9910463633903321 |
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Titolo |
Palliative care for infants, children, and adolescents : a practical handbook / / edited by Brian S. Carter, Marcia Levetown, Sarah E. Friebert |
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Pubbl/distr/stampa |
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Baltimore : , : Johns Hopkins University Press, , 2011 |
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ISBN |
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Edizione |
[Second edition.] |
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Descrizione fisica |
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1 online resource (556 p.) |
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Altri autori (Persone) |
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CarterBrian S. <1957-> |
FriebertSarah E |
LevetownMarcia <1960-> |
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Disciplina |
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Soggetti |
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Terminal care |
Terminally ill children - Care |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Epidemiology and health services research / Chris Feudtner and Kari R. Hexem -- Goals, values, and conflict resolution / Carson Strong ... [and others] -- Barriers to integrating palliative care, and potential resolutions / Patrick M. Jones ... [and others] -- Educational initiatives / Betty Ferrell ... [and others] -- The art of advocacy / Lori Butterworth ... [and others] -- Decision making / Robert J. Graham, Marcia Levetown, and Margaret Comeau -- Communication skills and relational abilities / Marcia Levetown, Elaine C. Meyer, and Dianne Gray -- Psychological needs of the child and family / Stacy F. Orloff, Barbara Jones, and Kris Ford -- Spiritual dimensions / Dexter Lanctot ... [and others] -- Holistic management of symptoms / Richard Hain ... [and others] -- Bereavement / Stacy F. Orloff ... [and others] -- The other side of caring : caregiver suffering / Cynda H. Rushton and M. Karen Ballard -- Palliative care in the neonatal-perinatal period / Suzanne S. Toce ... [and others] -- Palliative care in the pediatric intensive care Setting / Kathryn Weise ... [and others] -- Palliative care in the home, school, and community / Susan M. Huff ... [and others] -- Palliative care for the child who has a genetic condition / Sara L. Perszyk, Anthony Perszyk, |
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and Brian S. Carter -- Integrating palliative care with HIV care and treatment / Nancy Hutton, Cora K. Welsh, and Maureen E. Lyon -- Integrating palliative care with pediatric hematology/oncology / Sarah E. Friebert, Brian Greffe, and Janice Wheeler. |
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2. |
Record Nr. |
UNINA9910164341503321 |
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Autore |
Tveito Aslak |
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Titolo |
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models [[electronic resource] /] / by Aslak Tveito, Glenn T. Lines |
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Pubbl/distr/stampa |
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Basingstoke, : Springer Nature, 2015 |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
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ISBN |
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Edizione |
[1st ed. 2016.] |
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Descrizione fisica |
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1 online resource (XVI, 261 p. 129 illus., 30 illus. in color.) |
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Collana |
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Lecture Notes in Computational Science and Engineering, , 1439-7358 ; ; 111 |
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Disciplina |
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Soggetti |
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Computer mathematics |
Medicine |
Optical data processing |
Computational Science and Engineering |
Biomedicine, general |
Computer Imaging, Vision, Pattern Recognition and Graphics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di contenuto |
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Preface -- Background: Contents and Method -- One-dimensional calcium release -- Models of open and state blockers -- Two-dimensional calcium release -- Computing theoretical drugs in the two-dimensional case -- Generalized systems -- Calcium-induced calcium release -- Numerical release for CICR -- A prototypical model of an ion channel -- Inactivated ion channels -- A simple model of the sodium channel -- Mutations affecting the mean open time -- The burst mode -- Whole sale action potentials -- . |
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Sommario/riassunto |
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Flow of ions through voltage gated channels can be represented |
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theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model. |
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