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1. |
Record Nr. |
UNINA9910462987203321 |
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Autore |
Valkó Klára |
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Titolo |
Physicochemical and biomimetic properties in drug discovery : chromatographic techniques for lead optimization / / Klara Valko |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley, , 2014 |
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©2014 |
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ISBN |
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1-118-77041-2 |
1-118-77032-3 |
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Descrizione fisica |
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1 online resource (581 p.) |
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Disciplina |
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Soggetti |
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Drug development - Statistical methods |
Chromatographic analysis |
Clinical trials - Statistical methods |
Pharmaceutical biotechnology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Cover; Title Page; Copyright; Preface; Chapter 1: The Drug Discovery Process; Summary; Question for Review; References; Chapter 2: Drug-Likeness and Physicochemical Property Space of known Drugs; Summary; Questions for Review; References; Chapter 3: Basic Pharmacokinetic Properties; Absorption; Plasma Protein Binding; Distribution; Volume of Distribution; Unbound Volume of Distribution; Half-Life; Metabolism and Clearance; Free Drug Hypothesis; Summary; Questions for Review; References; Chapter 4: Principles and Methods of Chromatography for the Application of Property Measurements |
Theoretical Background of ChromatographyRetention Factor and its Relation to the Distribution Constant Between the Mobile and the Stationary Phases; Measure of Separation Efficiency; Resolution and Separation Time; Gradient Elution; Applicability of Chromatography for Measurements of Molecular Properties; Summary; Questions for Review; References; Chapter 5: Molecular Physicochemical Properties that Influence Absorption and Distribution-Lipophilicity; Partition |
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Coefficient; Lipophilicity Measurements by Reversed Phase Chromatography with Isocratic Elution |
Lipophilicity Measurements by Reversed Phase Chromatography with Gradient ElutionLipophilicity of Charged Molecules-pH Dependence of Lipophilicity; Biomimetic Lipophilicity Measurements by Chromatography; Comparing Various Lipophilicity Measures by the Solvation Equation Model; Summary; Questions for Review; References; Chapter 6: Molecular Physicochemical Properties that Influence Absorption and Distribution-Solubility; Definition of Solubility; Molecular Interactions with Water; Various Solubility Measurements that can be Applied During the Drug Discovery Process |
Conditions that Affect SolubilitySolubility-pH Profile; Solubility and Dissolution in Biorelevant Media; Composition of Fasted State Simulated Intestinal Fluid (FaSSIF); Preparation of FaSSIF Solution; Composition of Fed State Simulated Intestinal Fluid (FeSSIF); Preparation of FeSSIF Solution; Summary; Questions for Review; References; Chapter 7: Molecular Physicochemical Properties that Influence Absorption and Distribution-Permeability; Biological Membranes; Artificial Membranes; Physicochemical Principles of Permeability; Experimental Methods to Measure Artificial Membrane Permeability |
Relationships Between Permeability, Lipophilicity, and SolubilityChromatography as a Potential Tool for Measuring the Rate of Permeation; Summary; Questions for Review; References; Chapter 8: Molecular Physicochemical Properties that Influence Absorption and Distribution-Acid Dissociation Constant-pKa; Definition of pKa; Methods for Determining pKa; Spectrophotometric Determination of pKa; Determination of pKa by Capillary Electrophoresis; Chromatographic Approaches for the Determination of pKa; Summary; Questions for Review; References |
Chapter 9: Models with Measured Physicochemical and Biomimetic Chromatographic Descriptors-Absorption |
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Sommario/riassunto |
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Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measure |
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2. |
Record Nr. |
UNINA9910789680103321 |
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Titolo |
Studies in the book of Tobit [[electronic resource] ] : a multidisciplinary approach / / edited by Mark Bredin |
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Pubbl/distr/stampa |
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London ; ; New York, : T & T Clark, c2006 |
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ISBN |
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1-283-19211-X |
9786613192110 |
0-567-01865-2 |
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Descrizione fisica |
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1 online resource (206 p.) |
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Collana |
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Library of Second Temple studies ; ; 55 |
T & T Clark library of biblical studies |
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Altri autori (Persone) |
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Disciplina |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Introduction / Mark Bredin -- Tobit in Spain : some preliminary comments on the relations between the Old Latin witnesses / Simon Gathercole -- Some neglected texts of Tobit : the third Greek version / Stuart Weeks -- Significance of Jonah in Vaticanus (B) Tobit 14.4 and 8 / Mark Bredin -- 'Sarah is the hero' : Kierkegaard's reading of Tobit in Fear and trembling / Hugh Pyper -- Tobit in the art of the Florentine Renaissance / Trevor Hart -- Tobit and the Jewish literary tradition / Shalom Goldman -- 'Bread on the grave of the righteous' (Tob. 4.17) / Nathan MacDonald -- Family life and ethnicity in early Israel and in Tobit / ekka Pitkänen -- Archangel Raphael in the book of Tobit / Margaret Barker -- Family, fertility, and foul smell : Tobit and Judith / Hans J. Lundager Jensen -- Tobit as a parable for the exiles of northern Israel / Richard Bauckham -- Food and drink in Tobit and other 'diaspora novellas' / Nathan MacDonald. |
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Sommario/riassunto |
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The essays collected here approach the book of Tobit from a range of disciplines: literary, feminist, anthropological, imagination, theological, textual and historical. This multi-disciplinary approach will generate new ideas and approaches to the book of Tobit. The essays vary not only in methodology used, but also in the texts that they examine. The book considers in detail some Latin manuscripts, encompassing an |
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article introducing a print of the Ceriani Latin text, and includes an overview of the Old Latin textual tradition and context. There is a comparison between two Greek manuscripts o |
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