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Record Nr. |
UNINA9910462572903321 |
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Titolo |
Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft |
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Pubbl/distr/stampa |
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Norfolk, England : , : Caister Academic Press, , [2013] |
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©2013 |
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ISBN |
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Descrizione fisica |
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1 online resource (249 p.) |
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Disciplina |
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Soggetti |
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Bacterial toxins |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Table of Contents; Chapter 1. Receptor-related Risk Factors for Verotoxin Pathogenesis; Verotoxins and their receptors; Receptor glycolipid; B subunit receptor-binding sites; VT signalling and internalization; Cholesterol masking of VT receptors; New model for VTB subunit pentamer binding plasma membrane Gb3; Cholesterol is key for VT-Gb3 retrograde transport; Regulation of Gb3 biosynthesis; Soluble GSL mimics; Conclusions; References; Chapter 2. The Helicobacter pylori CagA Protein: A Multifunctional BacterialToxin Delivered by Type IV Secretion; Introduction |
The cag pathogenicity island and its effector protein CagAThe Cag type IV secretion system as a toxin delivery system; CagA interaction partners and associated effects in host cells; Conclusions; Chapter 3. Pore-forming Toxins; Introduction; Introduction to Staphylococcus aureus α-haemolysin; Nomenclature and early observations; Primary structure and regulation of toxin production; Three-dimensional structure and function; Role in disease pathogenesis; Summary and future perspectives - α-toxin |
Introduction to the cholesterol-dependent cytolysins and membrane attack complex/perforin (MACPF) family proteinsGeneral features of the CDC primary structure; The CDC monomer crystal structure; Secretion of the CDCs; Cellular recognition; The CDC membrane anchoring system; The CDC allosteric pathway; Formation of the prepore |
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oligomer; Formation of the pore complex; Ring versus arc oligomers; The CDCs and bacterial pathogenesis; The membrane attack complex/perforin (MACPF) proteins; Summary and futureperspectives - CDCs andMACPF proteins; References |
Chapter 4. Bacterial Enterotoxins as Immunomodulators and Vaccine AdjuvantsIntroduction; Cholera toxin: the prototype for ADP-ribosylating holotoxin adjuvants; LT: a more complex family of holotoxin adjuvants; Are ADP-ribosylating toxins in general good adjuvants?; Taking toxin adjuvant immunomodulation one step further; Concluding remarks; References; Chapter 5. Mobile Genetic Elements as Carriers for Bacterial Virulence Genes; Core and adaptive genome; The mobile bacterial genome; Mobile genetic elements and their role in virulence; Why MGEs encode exotoxins and other virulence factors? |
Role of SOS inductionBacteriophage-encoding toxins and other virulence factors; Plasmids encoding toxins; Pathogenicity islands encoding toxins; Open questions; Web resources; References; Chapter 6. The Staphylococcal Superantigen-like Toxins; Introduction; The SSLs - an introduction; Genetics of the ssls; Molecular biology of the SSLs; SSL-related S. aureus immune evasion molecules; Mechanisms of immune evasion mediated by SSLs; Novel SSL-associated applications; Concluding remarks; References; Chapter 7. Botulinum Neurotoxins as Therapeutics; Introduction |
Mechanistic basis of BoNTs as therapeutics |
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Sommario/riassunto |
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Toxins are virulence determinants that play an important role in microbial pathogenicity and/or evasion of the host immune response. This makes them ideal targets for the development of novel antimicrobial strategies. The potential applications of toxin research extend beyond simply combating microbial pathogens, and include use as novel anti-cancer drugs and other front-line medicines and as tools in neurobiology. In the field of cellular biology, toxins have become invaluable as tools for the manipulation and investigation of fundamental cellular and physiological processes. Research in this |
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2. |
Record Nr. |
UNINA9910795187603321 |
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Titolo |
Brill's companion to the reception of Plutarch / / edited by Sophia Xenophontos, Katerina Oikonomopoulou |
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Pubbl/distr/stampa |
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Leiden, The Netherlands ; ; Boston : , : Brill, , [2019] |
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©2019 |
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ISBN |
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Descrizione fisica |
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Collana |
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Brill's companions to classical reception ; ; Volume 20 |
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Disciplina |
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Soggetti |
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History, Ancient - Historiography |
Civilization, Classical - Influence |
Art appreciation |
Influence (Literary, artistic, etc.) |
Criticism, interpretation, etc. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Front Matter -- Copyright page -- Acknowledgements -- Figures -- Table of Latin Abbreviations of Titles of Plutarch’s Moralia with English Translation -- Table of Latin Abbreviations of Plutarch’s Lives -- Notes on Editors and Contributors -- Note to the Reader -- Introduction / Sophia Xenophontos and Katerina Oikonomopoulou -- The Early Fame -- Plutarch in Macrobius and Athenaeus / Maria Vamvouri Ruffy -- Plutarch in Gellius and Apuleius / Katerina Oikonomopoulou -- Plutarch’s Reception in Imperial Graeco-Roman Philosophy / Mauro Bonazzi -- Plutarch and Atticism: Herodian, Phrynichus, Philostratus / Katarzyna Jażdżewska -- Plutarch and the Papyrological Evidence / Thomas Schmidt -- Late Antiquity and Byzantium -- Plutarch and Early Christian Theologians / Arkadiy Avdokhin -- Plutarch in Christian Apologetics (Eusebios, Theodoretos, Cyril) / Sébastien Morlet -- Plutarch and the Neoplatonists: Porphyry, Proklos, Simplikios / Elsa Giovanna Simonetti -- On Donkeys, Weasels and New-Born Babies, or What Damaskios Learned from Plutarch / Geert Roskam -- Plutarch in Stobaios / Michele Curnis -- The Reception of Plutarch in Constantinople in the Ninth and Tenth Centuries / András Németh -- |
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The Reception of Plutarch in Michael Psellos’ Philosophical, Theological and Rhetorical Works: an Elective Affinity / Eudoxia Delli -- Plutarch in Michael Psellos’ Chronographia / Diether Roderich Reinsch -- Plutarch and Zonaras: from Biography to a Chronicle with a Political Leaning / Theofili Kampianaki -- Plutarch in Twelfth-Century Learned Culture / Michael Grünbart -- Precepts, Paradigms and Evaluations: Niketas Choniates’ Use of Plutarch / Alicia Simpson -- Maximos Planoudes and the Transmission of Plutarch’s Moralia / Inmaculada Pérez Martín -- Plutarch and Theodore Metochites / Sophia Xenophontos -- Plutarch’s Reception in the Work of Nikephoros Xanthopoulos / Stephanos Efthymiadis -- Plutarch and Late Byzantine Intellectuals (c. 1350–1460) / Florin Leonte -- Other Medieval Cultures -- Plutarch in the Syriac Tradition: a Preliminary Overview / Alberto Rigolio -- Para-Plutarchan Traditions in the Medieval Islamicate World / Aileen Das and Pauline Koetschet -- Renaissance -- Leonardo Bruni and Plutarch / Marianne Pade -- Plutarch and Poliziano / Fabio Stok -- Plutarch’s French Translation by Amyot / ✝Françoise Frazier and Olivier Guerrier -- The First Editions of Plutarch’s Works, and the Translation by Thomas North / Michele Lucchesi -- Humanist Latin Translations of the Moralia / Francesco Becchi -- Plutarch and Montaigne / Christopher Edelman -- Taking Centre Stage: Plutarch and Shakespeare / Miryana Dimitrova -- Enlightenment and the Modern Age -- Plutarch from Voltaire to Stendhal / Francesco Manzini -- Plutarch and Goethe / Paul Bishop -- Plutarch and Adamantios Koraes / Sophia Xenophontos -- Plutarch and the Victorians / Isobel Hurst -- Plutarch and Cavafy / David Ricks -- Plutarch in American Literature: Emerson and Other Authors / Frieda Klotz -- Plutarch’s Fortune in Spain / Aurelio Pérez Jiménez -- A Sage and a Kibbutznik: Plutarch in Modern Hebrew Literature and Culture / Eran Almagor -- Back Matter -- Index Rerum et Nominum -- Index Locorum. |
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Sommario/riassunto |
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The Greek biographer and philosopher Plutarch of Chaeronea (c. 45-125 AD) makes a fascinating case-study for reception studies not least because of his uniquely extensive and diverse afterlife. Brill’s Companion to the Reception of Plutarch offers the first comprehensive analysis of Plutarch’s rich reception history from the Roman Imperial period through Late Antiquity and Byzantium to the Renaissance, Enlightenment and the modern era. The thirty-seven chapters that make up this volume, written by a remarkable line-up of experts, explore the appreciation, contestation and creative appropriation of Plutarch himself, his thought and work in the history of literature across various cultures and intellectual traditions in Europe, America, North Africa, and the Middle East. |
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