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1. |
Record Nr. |
UNINA9910461843803321 |
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Autore |
Zarrow Peter Gue |
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Titolo |
After empire [[electronic resource] ] : the conceptual transformation of the Chinese state, 1885-1924 / / Peter Zarrow |
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Pubbl/distr/stampa |
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Stanford, CA, : Stanford University Press, 2012 |
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ISBN |
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Descrizione fisica |
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1 online resource (413 p.) |
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Disciplina |
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Soggetti |
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Monarchy - China - History - 20th century |
Electronic books. |
China History 1861-1912 |
China History 1912-1928 |
China Politics and government 19th century |
China Politics and government 20th century |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Frontmatter -- Contents -- Preface -- Acknowledgments -- Introduction -- 1 Kang Youwei’s Philosophy of Power and the 1898 Reform Movement -- 2 Liang Qichao and the Citizen-State -- 3 “Sovereignty” and the Translated State -- 4 Voices of Receding Reaction -- 5 Identity, History, and Revolution -- 6 Restoration and Revolution -- 7 Founding the Republic of China -- 8 The Last Emperors -- Conclusion -- List of Characters -- Notes -- Bibliography -- Index |
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Sommario/riassunto |
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From 1885–1924, China underwent a period of acute political struggle and cultural change, brought on by a radical change in thought: after over 2,000 years of monarchical rule, the Chinese people stopped believing in the emperor. These forty years saw the collapse of Confucian political orthodoxy and the struggle among competing definitions of modern citizenship and the state. What made it possible to suddenly imagine a world without the emperor? After Empire traces the formation of the modern Chinese idea of the state through the radical reform programs of the late Qing (1885–1911), the Revolution of 1911, and the first years of the Republic through the final expulsion of the last emperor of the Qing from the Forbidden City in 1924. It |
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contributes to longstanding debates on modern Chinese nationalism by highlighting the evolving ideas of major political thinkers and the views reflected in the general political culture. Zarrow uses a wide range of sources to show how "statism" became a hegemonic discourse that continues to shape China today. Essential to this process were the notions of citizenship and sovereignty, which were consciously adopted and modified from Western discourses on legal theory and international state practices on the basis of Chinese needs and understandings. This text provides fresh interpretations and keen insights into China's pivotal transition from dynasty to republic. |
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2. |
Record Nr. |
UNINA9910143578003321 |
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Titolo |
Pharmacometrics : the science of quantitative pharmacology / / edited by Ene I. Ette, Anoixis Corporation, Paul J. Williams, University of the Pacific and Anoixis Corporation |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley-Interscience, , [2007] |
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©2007 |
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ISBN |
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1-118-67951-2 |
1-280-82698-3 |
9786610826988 |
0-470-08797-8 |
0-470-08796-X |
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Descrizione fisica |
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1 online resource (1227 p.) |
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Classificazione |
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Disciplina |
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Soggetti |
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Pharmacology |
Pharmacokinetics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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PHARMACOMETRICS; CONTENTS; CONTRIBUTORS; PREFACE; ACKNOWLEDGMENTS; 1. Pharmacometrics: Impacting Drug Development and Pharmacotherapy; PART I GENERAL PRINCIPLES; 2. |
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General Principles of Programming: Computer and Statistical; 3. Validation of Software for Pharmacometric Analysis; 4. Linear, Generalized Linear, and Nonlinear Mixed Effects Models; 5. Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods; 6. Estimating the Dynamics of Drug Regimen Compliance; 7. Graphical Displays for Modeling Population Data; 8. The Epistemology of Pharmacometrics; 9. Data Imputation |
PART II POPULATION PHARMACOKINETIC BASIS OF PHARMACOMETRICS10. Population Pharmacokinetic Estimation Methods; 11. Timing and Efficiency in Population Pharmacokinetic/Pharmacodynamic Data Analysis Projects; 12. Designing Population Pharmacokinetic Studies for Efficient Parameter Estimation; 13. Population Models for Drug Absorption and Enterohepatic Recycling; 14. Pharmacometric Knowledge Discovery from Clinical Trial Data Sets; 15. Resampling Techniques and Their Application to Pharmacometrics; 16. Population Modeling Approach in Bioequivalence Assessment |
PART III PHARMACOKINETICS / PHARMACODYNAMICS RELATIONSHIP: BIOMARKERS AND PHARMACOGENOMICS, PK/PD MODELS FOR CONTINUOUS DATA, AND PK/PD MODELS FOR OUTCOMES DATA17. Biomarkers in Drug Development and Pharmacometric Modeling; 18. Analysis of Gene Expression Data; 19. Pharmacogenomics and Pharmacokinetic/Pharmacodynamic Modeling; 20. Empirical Pharmacokinetic/Pharmacodynamic Models; 21. Developing Models of Disease Progression; 22. Mechanistic Pharmacokinetic/Pharmacodynamic Models I; 23. Mechanistic Pharmacokinetic/Pharmacodynamic Models II; 24. PK/PD Analysis of Binary (Logistic) Outcome Data |
25. Population Pharmacokinetic/Pharmacodynamic Modeling of Ordered Categorical Longitudinal Data26. Transition Models in Pharmacodynamics; 27. Mixed Effects Modeling Analysis of Count Data; 28. Mixture Modeling with NONMEM V; PART IV CLINICAL TRIAL DESIGNS; 29. Designs for First-Time-in-Human Studies in Nononcology Indications; 30. Design of Phase 1 Studies in Oncology; 31. Design and Analysis of Clinical Exposure: Response Trials; PART V PHARMACOMETRIC KNOWLEDGE CREATION; 32. Pharmacometric/Pharmacodynamic Knowledge Creation: Toward Characterizing an Unexplored Region of the Response Surface |
33. Clinical Trial Simulation: Theory34. Modeling and Simulation: Planning and Execution; 35. Clinical Trial Simulation: Efficacy Trials; PART VI PHARMACOMETRIC SERVICE AND COMMUNICATION; 36. Engineering a Pharmacometrics Enterprise; 37. Communicating Pharmacometric Analysis Outcome; PART VII SPECIFIC APPLICATION EXAMPLES; 38. Pharmacometrics Applications in Population Exposure-Response Data for New Drug Development and Evaluation; 39. Pharmacometrics in Pharmacotherapy and Drug Development: Pediatric Application |
40. Pharmacometric Methods for Assessing Drug-Induced QT and QTc Prolongations for Non-antiarrhythmic Drugs |
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Sommario/riassunto |
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Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of |
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3. |
Record Nr. |
UNINA9910784411803321 |
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Autore |
Bamford Sandra C. <1962-> |
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Titolo |
Biology unmoored : Melanesian reflections on life and biotechnology / / Sandra Bamford |
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Pubbl/distr/stampa |
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Berkeley : , : University of California Press, , 2007 |
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©2007 |
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ISBN |
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1-282-35837-5 |
9786612358371 |
0-520-93947-6 |
1-4337-0138-3 |
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Descrizione fisica |
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1 online resource (xiv, 230 pages) : illustrations, maps |
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Disciplina |
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Soggetti |
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Hamtai (Papua New Guinean people) - Ethnobiology |
Hamtai (Papua New Guinean people) - Agriculture |
Hamtai (Papua New Guinean people) - Psychology |
Human body - Social aspects - Papua New Guinea - Gulf Province |
Indigenous peoples - Ecology - Papua New Guinea - Gulf Province |
Ethnobiology - Papua New Guinea - Gulf Province |
Biotechnology |
Genetic engineering |
Gulf Province (Papua New Guinea) Social life and customs |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references (p. 191-218) and index. |
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Nota di contenuto |
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Introduction: conceptual frameworks -- Cultural landscapes -- Insubstantial identities -- Embodiments of detachment -- (Im) mortal undertakings -- Conceiving global identities -- Conclusion: conceptual displacements. |
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Sommario/riassunto |
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Biology Unmoored is an engaging examination of what it means to live in a world that is not structured in terms of biological thinking. Drawing upon three years of ethnographic research in the highlands of |
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Papua New Guinea, Sandra Bamford describes a world in which physiological reproduction is not perceived to ground human kinship or human beings' relationship to the organic world. Bamford also exposes the ways in which Western ideas about relatedness do depend on a notion of physiological reproduction. Her innovative analysis includes a discussion of the advent of assisted reproductive technologies (ARTs), the mapping of the human genome, cloning, the commodification of biodiversity, and the manufacture and sale of genetically modified organisms (GMOs). |
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