Building Brains [[electronic resource] ] : An Introduction to Neural Development

• Record Nr.: UNINA9910461651003321
• Autore: Price David
• Pubbl/distr/stampa: Hoboken, : Wiley, 2011
• ISBN: 0-470-97988-7; 1-119-95766-4
• Descrizione fisica: 1 online resource (350 p.)
• Altri autori (Persone): JarmanAndrew P; MasonJohn O; KindPeter C
• Disciplina: 612.8
• Soggetti: Developmental neurobiology; Nervous system --Growth; Developmental neurobiology - Growth; Nervous system; Neurons - physiology; Nervous System - anatomy & histology; Neurogenesis; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di contenuto: Building Brains: An Introduction to Neural Development; Contents; Preface; Conventions and Commonly used Abbreviations; 1 Models and Methods for Studying Neural Development; 1.1 What is neural development?; 1.2 Why research neural development?; 1.2.1 The uncertainty of current understanding; 1.2.2 Implications for human health; 1.2.3 Implications for future technologies; 1.3 Major breakthroughs that have contributed to understanding developmental mechanisms; 1.4 Invertebrate model organisms; 1.4.1 Fly; 1.4.2 Worm; 1.4.3 Other invertebrates; 1.5 Vertebrate model organisms; 1.5.1 Frog; 1.5.2 Chick1.5.3 Zebrafish; 1.5.4 Mouse; 1.5.5 Humans; 1.5.6 Other vertebrates; 1.6 Observation and experiment: methods for studying neural development; 1.7 Summary; 2 The Anatomy of Developing ; Nervous Systems; 2.1 The nervous system develops from the embryonic neuroectoderm; 2.2 Anatomical terms used to describe locations in embryos; 2.3 Development of the neuroectoderm of invertebrates; 2.3.1 C. elegans; 2.3.2 Drosophila; 2.4 Development of the neuroectoderm of vertebrates and the process of neurulation; 2.4.1 Frog; 2.4.2 Chick; 2.4.3 Mouse; 2.5 Secondary neurulation in vertebrates; 2.6 Formation of invertebrate and vertebrate peripheral nervous systems2.6.1 Invertebrates; 2.6.2 Vertebrates: the neural crest and the placodes; 2.6.3 Vertebrates: development of sense organs; 2.7 Summary; 3 Neural Induction: An Example of How Intercellular Signalling Determines Cell Fates; 3.1 What is neural induction?; 3.2 Specification and commitment; 3.3 The discovery of neural induction; 3.4 A more recent breakthrough: identifying molecules that mediate neural induction; 3.5 Conservation of neural induction mechanisms in Drosophila; 3.6 Beyond the default model - other signalling pathways involved in neural induction3.7 Signal transduction: how cells respond to intercellular signals; 3.8 Intercellular signalling regulates gene expression; 3.8.1 General mechanisms of transcriptional regulation; 3.8.2 Transcription factors involved in neural induction; 3.8.3 What genes do transcription factors control?; 3.8.4 Gene function can also be controlled by other mechanisms; 3.9 The essence of development: a complex interplay of intercellular and intracellular signalling; 3.10 Summary; 4 Patterning the Neuroectoderm; 4.1 Regional patterning of the nervous system4.1.1 Patterns of gene expression are set up by morphogens; 4.1.2 Patterning occurs within a monolayer epithelium; 4.1.3 Patterning happens progressively; 4.2 Patterning the anteroposterior (AP) axis of the DrosophilaCNS; 4.2.1 Creating domains of transcription factor expression; 4.2.2 Dividing the ectoderm into segmental units; 4.2.3 Assigning segmental identity - the Hox code; 4.3 Patterning the AP axis of the vertebrate CNS; 4.3.1 Hox genes are highly conserved; 4.3.2 Initial AP information is imparted by the mesoderm; 4.3.3 Mesoderm signals set up domains of transcription factor expression
• Sommario/riassunto: The development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and current intense world-wide scientific research. A greater knowledge of how nervous systems construct themselves will bring huge benefits for human health and future technologies. Unravelling the mechanisms that lead to the development of healthy brains should help scientists tackle currently incurable diseases of the nervous