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Record Nr. |
UNINA9910461616603321 |
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Titolo |
Neurodegeneration [[electronic resource] ] : metallostasis and proteostasis / / edited by Danilo Milardi and Enrico Rizzarelli |
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Pubbl/distr/stampa |
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Cambridge, : RSC Pub., 2011 |
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ISBN |
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Descrizione fisica |
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1 online resource (285 p.) |
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Collana |
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RSC drug discovery series, , 2041-3203 ; ; no. 7 |
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Altri autori (Persone) |
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MilardiDanilo |
RizzarelliEnrico |
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Disciplina |
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Soggetti |
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Nervous system - Degeneration |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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i-iv; v-viii; xi-xiv; 1-17.PDF.pdf; 18-45; 46-68; 69-82; 83-111; 112-140; 141-151; 152-173; 174-211; 212-225; 226-248; 249-258; 259-270 |
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Sommario/riassunto |
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Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed ""amyloid"") in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitab |
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