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Record Nr. |
UNINA9910461368803321 |
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Titolo |
Translational neuroscience : toward new therapies / / edited by Karoly Nikolich and Steven E. Hyman |
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Pubbl/distr/stampa |
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Cambridge, MA : , : The MIT Press, , [2015] |
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ISBN |
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0-262-32986-7 |
0-262-32985-9 |
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Descrizione fisica |
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1 online resource (319 p.) |
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Collana |
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Disciplina |
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Soggetti |
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Neurosciences - Research |
Nervous system - Diseases |
Drug development |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Intro; Contents; The Ernst Strüngmann Forum; List of Contributors; 1 - Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2 - What Do We Know about Early Onset Neurodevelopmental Disorders?; 3 - Psychotic Disorders and the Neurodevelopmental Continuum; 4 - Neurodevelopmental Disorders; 5 - Neurodegenerative Diseases; 6 - Preclinical and Clinical Understanding; 7 - Neurodegenerative Diseases |
8 - How Might We Get from Genes to Circuits to Disease?9 - How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10 - Pathophysiological Toolkit; 11 - Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12 - From Rodent Behavioral Models to Human Disorders; 13 - Bridging the Gap between Patients and Models; 14 - The Revolution Has Begun |
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Sommario/riassunto |
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Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. |
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