Policy issues in the development and adoption of biomarkers for molecularly targeted cancer therapies : workshop summary / / Sharyl J. Nass, Jonathan Phillips, and Margie Patlak, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine of the National Academies

• Record Nr.: UNINA9910460941803321
• Pubbl/distr/stampa: Washington, District of Columbia : , : The National Academies Press, , [2015]; ©2015
• ISBN: 0-309-36858-8
• Descrizione fisica: 1 online resource (100 p.)
• Disciplina: 616.994075
• Soggetti: Cancer - Treatment - United States; Cancer - Genetic aspects; Biochemical markers; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Front Matter; Reviewers; Acknowledgments; Contents; Boxes, Figures, and Tables; Acronyms; Workshop Summary; INTRODUCTION; MOLECULAR BIOLOGY REVOLUTION IN CANCER DIAGNOSIS AND TREATMENT; Lessons Learned from Single Analyte Tests; Next-Generation Sequencing; RNA Sequencing Tests; Tests for Circulating Tumor DNA; Business Climate for Developing Diagnostic Tests; CHALLENGES IN BIOMARKER TEST DEVELOPMENT; Setting Standards; Assessing Analytical Validity, Clinical Validity, and Clinical Utility; Sharing Data; REGULATORY OVERSIGHT CHALLENGES; Evolving Regulation of Laboratory-Developed Tests; Companion DiagnosticsCLINICAL IMPLEMENTATION CHALLENGES; Insufficient or Inadequate Specimens; Tsunami of Information; Choosing the Best Test; Time Delays; Lack of Resources; Reporting Test Results; Incidental Findings; REIMBURSEMENT CHALLENGES; Lack of Evidence; Investigational and Off-Label Uses; Incidental Findings; Greater Expense, But Not Necessarily Greater Value; GATHERING THE ; EVIDENCE: INNOVATIVE CLINICAL TRIALS; Basket Trials; Lung-MAP Umbrella Trial; Challenges with Basket and Umbrella Trials; GATHERING THE EVIDENCE: COVERAGE DECISIONS; Coverage with Evidence Development; The MolDx Approach to Test ReimbursementGreen Park Collaborative Recommendations; GATHERING THE EVIDENCE: DATABASES AND REGISTRIES; My Cancer Genome; ClinGen; Targeted Agent and Molecular Profiling Utilization Registry; Challenges in Using Databases; EDUCATION AND CLINICAL DECISION SUPPORT NEEDS; Guidelines; Treatment Pathways; RESEARCH NEEDS; CLOSING REMARKS; REFERENCES; Appendix: Workshop Statement of Task and Agenda; POLICY ISSUES IN THE DEVELOPMENT AND ADOPTION OF MOLECULARLY TARGETED THERAPIES FOR CANCER

Advances in materials technology for fossil power plants : proceedings from the seventh International Conference, October 22-25, 2013 Waikoloa, Hawaii, USA / / editors, D. Gandy, J. Shingledecker ; sponsored by Electric Power Research Institute

• Record Nr.: UNINA9910465810303321
• Pubbl/distr/stampa: Materials Park, Ohio : , : ASM International, , 2014; Materials Park, Ohio : , : ASM International, , [date of distribution not identified]; ©2014
• ISBN: 1-68015-940-2; 1-62708-061-9
• Descrizione fisica: 1 online resource (1520 p.)
• Disciplina: 621.312132
• Soggetti: Fossil fuel power plants - Materials; Power-plants - Materials; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Includes index.
• Nota di contenuto: ""#title_page_2013""; ""EPRI_COPYRIGHT""; ; ""OrganizingCommittee_2013""; ""InternationalAdvisoryBoard_2013""; ""TOC_EPRI2013""; ""Preface_2013_mt""; ""indexable_proof_New_12-16""; ""001_01_078_YeTao_Paper""; ""002_02_026_Augusto_11_20_13""; ""The ENCIO-project is financed by industrial and public funds. The project receives funding from the European Community's Research Fund for Coal and Steel (RFCS) under grant agreement n RFCPCT-2011-00003. The ENCIO project started on 1 July 2011. The ...""; ""003_03_022_Masafumi Fukuda_Paper""; ""004_04_125_JohnShingledecker_Paper_UPDATE_11_10_13""; ""005_05_158_India AUSC Paper""""006_06_087_HHendrix_Paper reformatted""; ""Steam Generator""; ""007_01_121_ArthurStam_Paper""; ""008_02_111_PaulWeitzel_Paper""; ""Increasing the efficiency of the Rankine regenerative-reheat steam cycle to improve the economics of electric power generation and to achieve lower cost of electricity has been a long sought after goal. Advanced ultra-supercritical (A-USC) development...""; ""The operation and start up of the 700C (1292F) plant will be similar in control methods and techniques to a 600C (1112F) plant. Due to arrangement features, the steam temperature control range and the once through minimum circulation flow will be slig...""""009_03_152_XishanXie_Paper_Update""; ""010_04_106_Srivastava_UPDATE_11_11_13""; ""011_05_107_Tortorelli_Paper""; ""012_06_109_Yujin Yang Final Paper_11_20_13""; ""ABSTRACT""; ""1 INTRODUCTION""; ""2 MATERIALS AND EXPERIMENTAL PROCEDURES""; ""3 RESULTS AND DISCUSSION""; ""3.1 Thermodynamic calculations""; ""3.2 Hardness""; ""3.3 MX precipitates""""3.4 Boundary precipitates""; ""3.5 Gamma prime""; ""4 CONCLUSIONS""; ""5 ACKNOWLEDGEMENTS""; ""6 REFERENCES""; ""013_01_147_Klenk_11_19_13""; ""014_02_019_PatrikSchraven""; ""015_03_007-ZDLiu_11_19_13""; ""016_04_030_FalkMueller_Paper_removes space before abstract""; ""017_05_156_NobuhikoSaito_Paper_11_19_13""; ""018_06_037_Imano_Hitachi_11_21_13""; ""019_07_017_BrianBaker_Paper_11_22_13_BABREV""; ""Table 5: Chemical Composition of INCONEL alloy 740H Filler Metal""; ""The macro-etched full cross section can be viewed in Figure 11 as well as the etched microstructure of a mounted and polished cross section. No micro-fissuring was observed in the heat-affected-zone (HAZ) or in the weld metal. Side bend testing (4T,...""""/""; ""/""; ""Table 6. Room Temperature Tensile Properties for ASME Section IX Qualifications from the Full Section HWGTAW Steam Header Pipe Weldment""; ""020_08_129_JohnShingledecker_Paper_UPDATE_11_10_13""; ""022_09_041_ShengdeZhang_Japan""; ""023_10_042_Gururaja UV_UPDATE_09_27_13""; ""024_11_091_2B_Shuangqun Zhao_11_20_13""; ""025_12_117__YangHuachun_Paper""