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Record Nr. |
UNINA9910460941803321 |
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Titolo |
Policy issues in the development and adoption of biomarkers for molecularly targeted cancer therapies : workshop summary / / Sharyl J. Nass, Jonathan Phillips, and Margie Patlak, rapporteurs ; National Cancer Policy Forum, Board on Health Care Services, Institute of Medicine of the National Academies |
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Pubbl/distr/stampa |
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Washington, District of Columbia : , : The National Academies Press, , [2015] |
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©2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (100 p.) |
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Disciplina |
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Soggetti |
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Cancer - Treatment - United States |
Cancer - Genetic aspects |
Biochemical markers |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Front Matter; Reviewers; Acknowledgments; Contents; Boxes, Figures, and Tables; Acronyms; Workshop Summary; INTRODUCTION; MOLECULAR BIOLOGY REVOLUTION IN CANCER DIAGNOSIS AND TREATMENT; Lessons Learned from Single Analyte Tests; Next-Generation Sequencing; RNA Sequencing Tests; Tests for Circulating Tumor DNA; Business Climate for Developing Diagnostic Tests; CHALLENGES IN BIOMARKER TEST DEVELOPMENT; Setting Standards; Assessing Analytical Validity, Clinical Validity, and Clinical Utility; Sharing Data; REGULATORY OVERSIGHT CHALLENGES; Evolving Regulation of Laboratory-Developed Tests |
Companion DiagnosticsCLINICAL IMPLEMENTATION CHALLENGES; Insufficient or Inadequate Specimens; Tsunami of Information; Choosing the Best Test; Time Delays; Lack of Resources; Reporting Test Results; Incidental Findings; REIMBURSEMENT CHALLENGES; Lack of Evidence; Investigational and Off-Label Uses; Incidental Findings; Greater Expense, But Not Necessarily Greater Value; GATHERING THE |
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EVIDENCE: INNOVATIVE CLINICAL TRIALS; Basket Trials; Lung-MAP Umbrella Trial; Challenges with Basket and Umbrella Trials; GATHERING THE EVIDENCE: COVERAGE DECISIONS; Coverage with Evidence Development |
The MolDx Approach to Test ReimbursementGreen Park Collaborative Recommendations; GATHERING THE EVIDENCE: DATABASES AND REGISTRIES; My Cancer Genome; ClinGen; Targeted Agent and Molecular Profiling Utilization Registry; Challenges in Using Databases; EDUCATION AND CLINICAL DECISION SUPPORT NEEDS; Guidelines; Treatment Pathways; RESEARCH NEEDS; CLOSING REMARKS; REFERENCES; Appendix: Workshop Statement of Task and Agenda; POLICY ISSUES IN THE DEVELOPMENT AND ADOPTION OF MOLECULARLY TARGETED THERAPIES FOR CANCER |
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2. |
Record Nr. |
UNINA9910823354203321 |
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Titolo |
Eco-efficient materials for mitigating building cooling needs : design, properties and applications / / edited by F. Pacheco-Torgal [and three others] ; contributors N. L. Alchapar [and thirty six others] |
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Pubbl/distr/stampa |
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Amsterdam, [Netherlands] : , : Woodhead Publishing, , 2015 |
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©2015 |
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ISBN |
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1-78242-401-6 |
1-78242-380-X |
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Descrizione fisica |
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1 online resource (552 p.) |
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Collana |
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Woodhead Publishing Series in Civil and Structural Engineering ; ; Number 56 |
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Disciplina |
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Soggetti |
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Building materials - Environmental aspects |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Front Cover; Eco-efficient Materials for Mitigating Building Cooling Needs: Design, Properties and Applications; Copyright; Contents; List of contributors; Woodhead Publishing Series in Civil and Structural Engineering; Foreword; Chapter 1: Introduction to eco-efficient materials to mitigate building cooling needs; 1.1. Climate change and |
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urban heat islands (UHIs); 1.2. Adaptation to climate change and mitigation of UHI effects and of building cooling needs; 1.3. Outline of the book; References; Part One: Pavements for mitigating urban heat island effects |
Chapter 2: Coating materials to increase pavement surface reflectance2.1. Introduction; 2.2. Organic polymers used as coating overlay materials for pavements; 2.2.1. Epoxy resins; 2.2.2. Acrylic ester polymers; 2.2.3. Advantages and disadvantages of various polymers; 2.3. Inorganic materials used as polymer fillers to increase reflectance; 2.3.1. White color materials for increasing visible light reflectance; 2.3.2. Various color materials for increasing NIR reflectance; 2.4. Aggregate materials with high reflectance; 2.5. Future trends; Acknowledgments; References |
Chapter 3: Pavements made of concrete with high solar reflectance3.1. Introduction; 3.2. Materials for high solar reflectance concrete; 3.2.1. Water; 3.2.2. Aggregates; 3.2.3. Portland cement; 3.2.4. Slag cement; 3.2.5. Latex; 3.2.6. Fly ash; 3.2.7. Pigments; 3.3. Heat transfer in pavements; 3.4. Other potential benefits of high solar reflectance concrete; 3.5. Modeling the benefits of widespread use of high solar reflectance concrete; 3.5.1. Benefits associated with the use of SCMs; 3.5.2. Benefits as a result of mitigating urban heat island effects |
3.6. Leadership in Energy and Environmental Design (LEED) credit3.7. Other resources; 3.8. Future trends; References; Chapter 4: A comparison of thermal performance of different pavement materials; 4.1. Introduction; 4.2. Albedo of pavement materials; 4.2.1. Albedo field measurement methods and equipment; 4.2.2. Pavement materials and plan for albedo measurement; 4.2.2.1. Pavement materials for albedo measurement; 4.2.2.2. Plan for albedo measurement; 4.2.3. Albedo values of different pavement materials; 4.2.3.1. Albedo of nine test sections without traffic |
4.2.3.2. Albedo of other different pavement materials from UCPRC testing pavements without traffic4.2.3.3. Albedo of slurry seal, cape seal, fog seal, and chip seal with more data of PCC and AC measured from field pavem...; 4.2.4. Main factors affecting field albedo measurement; 4.2.4.1. Influence of wind speed and air temperature; 4.2.4.2. Influence of cloudiness; 4.2.5. Diurnal and seasonal variation of albedo; 4.2.5.1. Diurnal variation of albedo; 4.2.5.2. Seasonal variation of albedo; 4.2.6. Change of albedo over time; 4.2.7. Summary of albedo of pavement materials |
4.3. Thermal properties of pavement materials |
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Sommario/riassunto |
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Climate change is one of the most important environmental problems faced by Planet Earth. The majority of CO2 emissions come from burning fossil fuels for energy production and improvements in energy efficiency shows the greatest potential for any single strategy to abate global greenhouse gas (GHG) emissions from the energy sector. Energy related emissions account for almost 80% of the EU's total greenhouse gas emissions. The building sector is the largest energy user responsible for about 40% of the EU's total final energy consumption. In Europe the number of installed air conditioning sys |
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