|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910460735003321 |
|
|
Titolo |
Endocannabinoids / / edited by Loren Parsons, Matthew Hill |
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Amsterdam : , : Elsevier Science, , 2015 |
|
|
|
|
|
|
|
ISBN |
|
0-12-801278-1 |
0-12-801376-1 |
|
|
|
|
|
|
|
|
Edizione |
[First edition.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (368 p.) |
|
|
|
|
|
|
Collana |
|
International review of neurobiology, , 0074-7742 ; ; volume one hundred and twenty-five |
|
|
|
|
|
|
|
|
Soggetti |
|
Cannabinoids |
Cannabinoids - Receptors |
Cannabinoids - Physiological effect |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Front Cover; Endocannabinoids; Copyright; Contents; Contributors; Preface; Chapter One: The Endocannabinoid Signaling System in the CNS: A Primer; 1. Introduction; 2. The Endocannabinoids; 2.1. Definitions; 2.2. Mechanisms of AEA Biosynthesis; 2.2.1. Precursor Synthesis; 2.2.2. NAPE Conversion to NAE: NAPE-PLD; 2.2.3. NAPE Conversion to NAE: Multienzyme Pathways; 2.2.4. AEA Synthesis from AA; 2.2.5. Summary; 2.3. Mechanisms of AEA Hydrolysis; 2.3.1. Fatty Acid Amide Hydrolase; 2.3.2. NAE-Hydrolyzing Acid Amidase: A Peripheral AEA Hydrolase; 2.4. Mechanisms of 2-AG Biosynthesis |
2.4.1. Diacylglycerol Lipase2.4.2. Mechanisms of DAG Synthesis; 2.5. Mechanisms of 2-AG Catabolism; 2.5.1. Monoacylglycerol Lipase; 2.5.2. Other Enzymes that Hydrolyze 2-AG in the Brain; 2.5.3. Contribution of 2-AG to AA Concentrations; 2.6. Other Inactivation Mechanisms for AEA and 2-AG; 2.6.1. Uptake, Accumulation, and Sequestration; 2.6.2. Oxygenation of the Arachidonate Backbone; 3. Endocannabinoid Receptors; 3.1. Introduction; 3.2. CB1 Cannabinoid Receptors; 3.2.1. CB1R Signaling; 3.2.2. CB1R Pharmacology; 4. CB1R and Retrograde Regulation of Synaptic Activity; 4.1. The Basic Paradigms |
|
|
|
|