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Record Nr. |
UNINA9910460528603321 |
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Titolo |
General and molecular pharmacology : principles of drug action / / edited by Francesco Clementi [and six others] |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley, , 2015 |
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©2015 |
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ISBN |
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1-118-76868-X |
1-118-76859-0 |
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Descrizione fisica |
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1 online resource (2938 p.) |
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Disciplina |
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Soggetti |
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Pharmaceutical chemistry |
Molecular biology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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COVER; TABLE OF CONTENTS; TITLE PAGE; LIST OF CONTRIBUTORS; PREFACE; SECTION 1: INTRODUCTION TO PHARMACOLOGY; 1 ESSENTIAL LEXICON OF PHARMACOLOGY; THE SOCIAL IMPACT OF PHARMACOLOGY; ESSENTIAL LEXICON; TAKE-HOME MESSAGE; 2 A SHORT HISTORY OF PHARMACOLOGY; BIRTH AND HISTORICAL DEVELOPMENTS OF PHARMACOLOGY; MODERN PHARMACOLOGY; THE BIOTECHNOLOGY ERA AND THE PHARMACOLOGY IN THE THIRD MILLENNIUM; TAKE-HOME MESSAGE; FURTHER READING; SECTION 2: GETTING THE DRUG TO ITS SITE OF ACTION; 3 CELLULAR BASIS OF PHARMACOKINETICS; A QUICK JOURNEY WITH THE DRUG IN THE BODY; CROSSING CELL MEMBRANES |
DRUG DIFFUSION TO ORGANS AND TISSUES TAKE-HOME MESSAGE; FURTHER READING; 4 DRUG ABSORPTION AND ADMINISTRATION ROUTES; GENERAL RULES ABOUT DRUG ABSORPTION RATE; ENTERAL ROUTES OF ADMINISTRATION; SYSTEMIC PARENTERAL ROUTES OF ADMINISTRATION; OTHER ROUTES OF DRUG ADMINISTRATION; ABSORPTION KINETICS; TAKE-HOME MESSAGE; FURTHER READING; 5 DRUG DISTRIBUTION AND ELIMINATION; DISTRIBUTION; ELIMINATION; RENAL EXCRETION OF DRUGS; HEPATIC EXCRETION AND |
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ENTEROHEPATIC CYCLE; TAKE-HOME MESSAGE; FURTHER READING; 6 DRUG METABOLISM; METABOLIC MODIFICATION OF DRUG ACTIVITY; TWO PHASES OF DRUG METABOLISM |
EXTRAHEPATIC BIOTRANSFORMATIONS PHARMACOMETABOLIC INDUCTION AND INHIBITION; TAKE-HOME MESSAGE; FURTHER READING; 7 CONTROL OF DRUG PLASMA CONCENTRATION; TIME COURSE OF DRUG PLASMA CONCENTRATION FOLLOWING A SINGLE ADMINISTRATION; DRUGS DISTRIBUTE TO ORGANS AND TISSUES AND THEN ARE ELIMINATED; DRUG PLASMA CONCENTRATION TIME COURSE DURING REPETITIVE ADMINISTRATIONS; MULTICOMPARTMENTAL KINETICS; CORRECTIONS OF THE THERAPEUTIC REGIMEN; TAKE-HOME MESSAGE; FURTHER READING; SECTION 3: RECEPTORS AND SIGNAL TRANSDUCTION; 8 DRUG-RECEPTOR INTERACTIONS: QUANTITATIVE AND QUALITATIVE ASPECTS |
GENERAL PROPERTIES OF DRUG RECEPTORS CHARACTERISTICS OF DRUG-RECEPTOR INTERACTION; QUANTITATIVE ASPECTS OF DRUG EFFECTS: DOSE-RESPONSE CURVES; FROM DRUG-RECEPTOR INTERACTION TO DRUG RESPONSE; TAKE-HOME MESSAGE; FURTHER READING; 9 RECEPTORS AND MODULATION OF THEIR RESPONSE; CLASSES OF RECEPTORS AND STRATEGIES OF SIGNAL TRANSDUCTION; CONTROL OF RECEPTOR LOCALIZATION IN THE CELL MEMBRANE; INTRACELLULAR TRAFFIC OF CELL RECEPTORS; MODULATION OF RECEPTOR RESPONSES; RECEPTOR MODULATION BY DRUGS; TAKE-HOME MESSAGE; FURTHER READING; 10 ADAPTATION TO DRUG RESPONSE AND DRUG DEPENDENCE |
MOLECULAR, CELLULAR, AND SYSTEMIC ADAPTATION DRUG ADDICTION AS A PARADIGM OF ALLOSTATIC ADAPTATION; THERAPY FOR DRUG DEPENDENCE; TAKE-HOME MESSAGE; FURTHER READING; 11 PHARMACOLOGICAL MODULATION OF POSTTRANSLATIONAL MODIFICATIONS; PROTEIN PHOSPHORYLATION; SUMOylation; UBIQUITINATION; GLYCOSYLATION; ACETYLATION; HYDROXYLATION; CARBOXYLATION; METHYLATION; S-NITROSYLATION; DISULFIDE BONDS; LIPID MODIFICATIONS; PHARMACOLOGICAL MODULATION OF POST TRANSLATIONAL MODIFICATIONS; TAKE-HOME MESSAGE; FURTHER READING; 12 CALCIUM HOMEOSTASIS WITHIN THE CELLS; THE CYTOSOL: A CROSSROAD OF Ca2+ FLUXES |
THE PLASMA MEMBRANE: CHANNELS, PUMPS, AND TRANSPORTERS |
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Sommario/riassunto |
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With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action - the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students Discusses the relevance of pharmacokinetics and drug development |
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