The enzymes . Volume thirty eight Platelet-activating factor acetylhydrolases (PAF-AH) / / edited by Keizo Inoue, Diana M. Stafforini, Fuyuhiko Tamanoi ; contributors, Hiroyuki Arai [and eleven others]

• Record Nr.: UNINA9910460473103321
• Pubbl/distr/stampa: Amsterdam, [Netherlands] : , : Academic Press, , 2015; ©2015
• ISBN: 0-12-803908-6; 0-12-803946-9
• Descrizione fisica: 1 online resource (232 p.)
• Collana: Enzymes, , 1874-6047 ; ; Volume 38
• Disciplina: 612.115
• Soggetti: Platelet activating factor; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and indexes.
• Nota di contenuto: Front Cover; Platelet-Activating Factor Acetylhydrolases (PAF-AH); Copyright; Contents; Contributors; Preface; Chapter One: Overview of PAF-Degrading Enzymes; 1. Introduction; 2. Intracellular PAF-AH I; 2.1. Characteristics; 2.2. Brain Development; 2.3. Spermatogenesis; 2.4. Aβ Generation and Secretion; 2.5. Cancer Pathogenicity; 2.6. Protein Trafficking and Sorting; 2.7. Aspirin Metabolism; 3. Intracellular PAF-AH II; 3.1. Characteristics; 3.2. Protective Role Against Oxidative Stress; 3.3. Epidermal Morphogenesis; 3.4. Transacetylation from PAF to Other Lipid Mediators; 4. Plasma PAF-AH; 4.1. Characteristics4.2. Involvement of Atherosclerosis; 4.3. Involvement in Asthma; 5. Conclusion; References; Chapter Two: Intracellular PAF-Acetylhydrolase Type I; 1. Introduction and History; 2. Identification of Intracellular PAF-AH, Isoform Ib; 3. Nomenclature of PAF-AH Ib Subunits; 4. Structure of PAF-AH Ib; 4.1. Structure of the Catalytic Subunits; 4.2. Structure of the Noncatalytic Subunit; 5. Physiological Roles of PAF-AH Ib; 5.1. Neuronal Development and Function; 5.2. Interaction Between PAF-AH Ib and the Reelin Signaling Pathway; 5.3. Spermatogenesis; 5.4. Cancer; 5.5. Other Cellular Processes that Possibly Involve PAF-AH Ib6. Remaining Questions and Future Prospects; Acknowledgments; References; Chapter Three: Platelet-Activating Factor Acetylhydrolase and Brain Development; 1. Introduction; 2. Genetics of Human Lissencephaly and Recognition of the LIS1-Encoded Protein as PAFAH1B1; 3. Role of Pafah1b and Platelet-Activating Factor in Brain Development; 4. Coordination of Brain Platelet-Activating Factor Acetylhydrolase Signaling and Reelin Signaling in Mouse Brain; 5. Roles of ""Brain"" Platelet-Activating Factor Acetylhydrolase in Testicular Development and Spermatogenesis6. Conclusions; References; Chapter Four: Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That ...; 1. Introduction; 2. Structure of PAF-AH (II); 3. Substrate Specificity of PAF-AH (II); 4. Biological Roles of PAF-AH (II); 5. Regulation of PAF-AH (II); 6. Future Prospects; Acknowledgments; References; Chapter Five: Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II; 1. Introduction; 1.1. PAFAH Family1.2. Oxidative Stress; 1.3. PAFAH-II as a Transacetylase; 1.4. Homology Model of PAFAH-II; 2. Trafficking of PAFAH-II; 2.1. Previous Research; 2.2. Recent Discovery; 3. Oligomeric Regulation of PAFAH-II; 4. Conclusions and Future Work; Acknowledgment; References; Chapter Six: Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression; 1. Introduction and Perspectives; 2. Biochemical Properties of Plasma PAF-AH; 2.1. Generalities; 2.2. Substrate Specificity; 2.3. Susceptibility to Oxidation; 3. Association with Lipoproteins; 3.1. PAF-AH and Lipoproteins