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1. |
Record Nr. |
UNINA9910460461903321 |
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Titolo |
Plant cyclotides / / volume editor, David J. Craik, Institute for Molecular Bioscience, the University of Queensland, Brisbane, QLD, Australia |
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Pubbl/distr/stampa |
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Amsterdam : , : Elsevier, , 2015 |
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ISBN |
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0-12-800030-9 |
0-12-800797-4 |
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Edizione |
[First edition.] |
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Descrizione fisica |
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1 online resource (404 p.) |
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Collana |
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Advances in botanical research, , 0065-2296 ; ; volume seventy-six |
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Soggetti |
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Botany - Research |
Plant molecular biology |
Plant proteomics |
Peptides |
Botanical chemistry |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Front Cover; ADVANCES IN BOTANICAL RESEARCH; Plant Cyclotides; Copyright; Contents; CONTRIBUTORS; PREFACE; One - Overview on the Discovery and Applications of Cyclotides; 1. INTRODUCTION; ACKNOWLEDGMENTS; REFERENCES; Two - Cyclotides in the Violaceae; 1. THE DISCOVERY OF CYCLOTIDES IN VIOLACEAE; 2. UNLOCKING THE CYCLOTIDE LIBRARY; 3. THE VIOLACEAE; 4. VIOLACEAE-THE PHARMACOPOEIA; 5. GROWING NEEDS AND SOURCES OF CYCLOTIDES; 6. COMPLETING THE CIRCLE; ACKNOWLEDGMENTS; REFERENCES; Three - Cyclotides in the Rubiaceae; 1. INTRODUCTION; 2. DISCOVERY OF CYCLOTIDES |
2.1 Cyclotide Analytical Screening Workflow2.2 Cyclotides Sequence Analysis Using Transcriptomics and Peptidomics; 3. DISTRIBUTION OF CYCLOTIDES IN RUBIACEAE; 3.1 Rubiaceae-An Overview; 3.2 Morphology and Taxonomy of Rubiaceae; 3.3 Distribution of Cyclotides within Rubiaceae; 3.4 Cyclotide Precursors of Rubiaceae Plants; 3.5 Cyclotide Sequence Variations within Rubiaceae; 3.6 Distribution of Cyclotides in Other Gentianales; 4. EVOLUTION OF CYCLOTIDES; 5. |
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BIOACTIVITIES OF RUBIACEAE CYCLOTIDES; 6. CONCLUSION AND OUTLOOK; ACKNOWLEDGMENTS; REFERENCES; Four - Cyclotides from Chinese Plants |
1. Introduction2. Chemical Detection Method for Cyclotides; 3. Distribution and Chemotaxonomy of Cyclotides in Chinese Plants; 4. Extraction, Isolation and Structural Elucidation of Cyclotides in Chinese Plants; 4.1 Extraction and Isolation of Cyclotides in Chinese Plants; 4.2 Tandem MS Sequencing of Cyclotides in Chinese Plants; 4.3 NMR Characterization of Cyclotides in Chinese Plants; 5. Biological Activity of Cyclotides in Chinese Plants; Acknowledgments; References; Five - Primary Structural Analysis of Cyclotides; 1. CYCLOTIDE DISCOVERY-UNTANGLING THE CYSTINE KNOT |
2. TOOLS FOR PEPTIDE SEQUENCE ASSIGNMENT2.1 Gene Sequencing; 2.2 Genome Mining; 2.3 Next-Generation Sequencing; 2.4 Peptide Extraction and Purification; 2.5 Acid Hydrolysis and Amino Acid Analysis; 2.6 Edman Degradation; 2.7 Chemical and Enzymatic Digestion; 3. MASS SPECTROMETRY; 3.1 Ionization; 3.1.1 Electrospray Ionization; 3.1.2 Nanoelectrospray Ionization; 3.1.3 Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry; 3.2 Mass Analyzers; 3.2.1 Quadrupole Mass Analyzers; 3.2.2 TOF Mass Analyzers; 3.3 Peptide Sequencing; 4. APPLICATION OF MASS SPECTROMETRY TO CYCLOTIDE SEQUENCING |
4.1 MS Analysis of Cyclotides4.2 Tandem Mass Spectrometric (MS/MS) Analysis of Cyclotides; 4.3 Application of "Omics" Technologies to Cyclotide Sequencing; 5. CHALLENGES AND COMPLEXITIES; 5.1 Co-eluting, Isobaric Peptides; 5.2 N/D Isoforms; 5.3 Unknown Genomes/Incomplete DBs; 6. FUTURE PROSPECTS; 6.1 Transcriptomics and Bioinformatics; 6.2 Automation and Robotics; 6.3 Advances in MS Hardware; 6.4 Advances in MS Software; 7. CONCLUDING REMARKS; REFERENCES; Six - Structural Studies of Cyclotides; 1. THE CYCLIC CYSTINE KNOT; 2. STRUCTURAL FEATURES OF CYCLOTIDES; 2.1 Structural Studies |
2.2 Möbius, Bracelets, and Trypsin Inhibitors |
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2. |
Record Nr. |
UNINA9910511992203321 |
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Autore |
Organization World Health |
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Titolo |
Antimicrobial Resistance. Global Report on Surveillance [[electronic resource] ] : Global Report on Surveillance |
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Pubbl/distr/stampa |
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Geneva, : World Health Organization, 2014 |
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ISBN |
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Descrizione fisica |
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1 online resource (254 p.) |
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Disciplina |
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Soggetti |
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Drug resistance -- Periodicals |
Drug resistance in microorganisms |
Drug resistance |
Anti-infective agents - Classification |
Drug resistance in microorganisms - Effect of drugs on |
Risk management |
Risk |
Risk Management |
Information Science |
Drug Resistance |
Microbiological Phenomena |
Epidemiologic Measurements |
Therapeutic Uses |
Probability |
Pharmacologic Actions |
Pharmacological Phenomena |
Public Health |
Organization and Administration |
Statistics as Topic |
Health Services Administration |
Environment and Public Health |
Chemical Actions and Uses |
Physiological Phenomena |
Health Care Evaluation Mechanisms |
Health Care |
Epidemiologic Methods |
Drug Therapy |
Quality of Health Care |
Investigative Techniques |
Diagnostic Techniques and Procedures |
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Health Care Quality, Access, and Evaluation |
Anti-Infective Agents |
Classification |
Risk Assessment |
Drug Resistance, Microbial |
Biology |
Health & Biological Sciences |
Microbiology & Immunology |
Electronic books. |
Publication Formats |
Technical Report |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Cover; Contents; Foreword; Summary; Acknowledgements; Abbreviations; Introduction; SECTION 01 Resistance to antibacterial drugs; 1.1 Background; 1.1.1 Limitations; 1.2 Regional surveillance of antibacterial resistance; 1.2.1 WHO African Region; 1.2.2 WHO Region of the Americas; 1.2.3 WHO Eastern Mediterranean Region; 1.2.4 WHO European Region; 1.2.5 WHO South-East Asia Region; 1.2.6 WHO Western Pacific Region; 1.3 References; SECTION 02 Resistance to antibacterial drugs in selected bacteria of international concern; 2.1 Availability of national resistance data; 2.1.1 Key messages |
2.2 Resistance data on specific pathogens2.2.1 Escherichia coli - resistance to third-generation cephalosporins and to fluoroquinolones; 2.2.2 Klebsiella pneumoniae - resistance to third-generation cephalosporins and to carbapenems; 2.2.3 Staphylococcus aureus - resistance to methicillin; 2.2.4 Streptococcus pneumoniae - resistance (non-susceptibility) to penicillin; 2.2.5 Nontyphoidal Salmonella - resistance to fluoroquinolones; 2.2.6 Shigella species - resistance to fluoroquinolones; 2.2.7 Neisseria gonorrhoeae - decreased susceptibility to third-generation cephalosporins; 2.3 References |
SECTION 03 The health and economic burden due to antibacterial resistance3.1 Methods; 3.2 Findings; 3.2.1 Health burden; 3.2.2 Economic burden; 3.3 Knowledge gaps; 3.4 Key messages; 3.5 References; SECTION 04 Surveillance of antimicrobial drug resistance in disease-specific programmes; 4.1 Tuberculosis; 4.1.1 Evolution of drug resistance in tuberculosis; 4.1.2 Surveillance of drug-resistant tuberculosis; 4.1.3 Global public health response to drug-resistant tuberculosis; 4.1.4 Notification of MDR-TB cases and enrolment on treatment |
4.1.5 Public health implications: treatment outcomes for multidrug-resistant and extensively drug-resistant tuberculosis4.1.6 Key messages; 4.2 Malaria; 4.2.1 Evolution of antimalarial drug resistance; 4.2.2 Surveillance of antimalarial therapeutic efficacy and resistance; 4.2.3 Global public health implications of antimalarial drug resistance; 4.2.4 Key messages; 4.3 HIV; 4.3.1 Surveillance of anti-HIV drug resistance; 4.3.2 Global public health implications of anti-HIV drug resistance; 4.3.3 Key messages; 4.4 Influenza; 4.4.1 Evolution of |
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resistance in influenza viruses |
4.4.2 Anti-influenza drug resistance4.4.3 Surveillance of anti-influenza drug resistance; 4.4.4 Public health implications of anti-influenza drug resistance; 4.4.5 Key messages; 4.5 References; SECTION 05 Surveillance of antimicrobial resistance in other areas; 5.1 Antibacterial resistance in food-producing animals and the food chain; 5.1.1 Ongoing surveillance of antimicrobial resistance in food-producing animals and food; 5.1.2 Integrated surveillance of antimicrobial resistance in foodborne bacteria; 5.1.3 Antimicrobials of particular importance in human and veterinary medicine |
5.1.4 Implications for human health from zoonotic transmission of resistant bacteria and genetic material |
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Sommario/riassunto |
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This WHO report produced in collaboration withMember States and other partners provides as accuratea picture as is presently possible of the magnitude ofAMR and the current state of surveillance globally.The report focuses on antibacterial resistance (ABR)in common bacterial pathogens. Why? There is amajor gap in knowledge about the magnitude of thisproblem and such information is needed to guideurgent public health actions. ABR is complex andmultidimensional. It involves a range of resistancemechanisms affecting an ever-widening range ofbacteria most of which can cause a wide spectrumof disea |
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3. |
Record Nr. |
UNINA9910856600803321 |
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Autore |
Merquior, José G. |
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Titolo |
Foucault / José G. Merquior |
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Pubbl/distr/stampa |
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ISBN |
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Descrizione fisica |
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Collana |
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Disciplina |
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Locazione |
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Collocazione |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Trad. di Salvatore Maddaloni |
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