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1. |
Record Nr. |
UNINA9910451270903321 |
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Titolo |
Angiogenesis [[electronic resource] ] : an integrative approach from science to medicine / / edited by William D. Figg, Judah Folkman |
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Pubbl/distr/stampa |
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New York, NY, : Springer, c2008 |
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ISBN |
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1-281-37805-4 |
9786611378059 |
0-387-71518-5 |
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Edizione |
[1st ed. 2008.] |
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Descrizione fisica |
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1 online resource (616 p.) |
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Altri autori (Persone) |
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FiggWilliam D |
FolkmanM. Judah |
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Disciplina |
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Soggetti |
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Neovascularization |
Blood - Circulation |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process -- History of Angiogenesis -- Angiogenesis and Vascular Remodeling in Inflammation and Cancer: Biology and Architecture of the Vasculature -- Endothelial Cell Activation -- Pericytes, the Mural Cells of the Microvascular System -- Matrix Metalloproteinases and Their Endogenous Inhibitors -- Integrins in Angiogenesis -- Angiogenesis and Regulatory Proteins -- Fibroblast Growth Factor-2 in Angiogenesis -- Vascular Permeability/Vascular Endothelial Growth Factor -- Platelet-Derived Growth Factor -- Angiopoietins and Tie Receptors -- Basement Membrane Derived Inhibitors of Angiogenesis -- Angiostatin and Endostatin: Angiogenesis Inhibitors in Blood and Stroma -- Thrombospondins: Endogenous Inhibitors of Angiogenesis -- Molecular & Cellular Mechanisms of the Angiogenic Process -- Overview of Angiogenesis During Tumor Growth -- Hypoxic Regulation of Angiogenesis by HIF-1 -- Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2 -- Nitric Oxide in Tumor Angiogenesis -- VEGF Signal Tranduction in Angiogenesis -- Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis -- Immune Cells and Inflammatory |
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Mediators as Regulators of Tumor Angiogenesis -- Contribution of Endothelial Progenitor Cells to the Angiogenic Process -- Tumor Angiogenesis and the Cancer Stem Cell Model -- Targeting the Tumor Microenvironment (Stroma) for Treatment of Metastasis -- Functional Assessments of Angiogenesis -- Normalization of Tumor Vasculature and Microenvironment -- Targeted Drug Delivery to the Tumor Neovasculature -- Models for Angiogenesis -- Surrogates for Clinical Development -- Imaging of Angiogenesis -- Tumor Endothelial Markers -- Clinical Translation of Angiogenesis Inhibitors -- Overview and Clinical Applications of VEGF-A -- Protein Tyrosine Kinase Inhibitors as Antiangiogenic Agents -- Therapeutic Strategies that Target the HIF System -- The Clinical Utility of Bevacizumab -- Development of Thalidomide and Its IMiD Derivatives -- TNP-470: The Resurrection of the First Synthetic Angiogenesis Inhibitor -- Clinical Development of VEGF Trap -- Recent Advances in Angiogenesis Drug Development -- Combination of Antiangiogenic Therapy with Other Anticancer Therapies -- Immunotherapy of Angiogenesis with DNA Vaccines -- Challenges of Antiangiogenic Therapy of Tumors -- Pharmacogenetics of Antiangiogenic Therapy -- Angiogenesis in Health & Disease -- Angiogenesis in the Central Nervous System -- Lymphatic Vascular System and Lymphangiogenesis -- Ocular Neovascularization -- Angiogenesis and Pathology in the Oral Cavity -- Revascularization of Wounds: The Oxygen-Hypoxia Paradox -- Journeys in Coronary Angiogenesis -- Perspectives on the Future of Angiogenesis Research. |
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Sommario/riassunto |
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Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases. This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters. Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications. |
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2. |
Record Nr. |
UNINA9910460198903321 |
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Titolo |
Enhancing and expanding undergraduate research : a systems approach / / Mitchell Malachowski [and three others], editors |
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Pubbl/distr/stampa |
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San Francisco, [California] : , : Jossey-Bass, , 2015 |
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©2015 |
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ISBN |
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1-119-06129-6 |
1-119-06149-0 |
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Descrizione fisica |
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1 online resource (123 p.) |
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Collana |
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New Directions for Higher Education ; ; Number 169, Spring 2015 |
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Disciplina |
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Soggetti |
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Universities and colleges - Research |
Universities and colleges - Research - United States |
Research - Study and teaching (Higher) - United States |
University cooperation - United States |
Consortia - United States |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Enhancing and Expanding Undergraduate Research: A Systems Approach; CONTENTS; EDITORS' NOTES; 1 Realizing Student, Faculty, and Institutional Outcomes at Scale: Institutionalizing Undergraduate Research, Scholarship, and Creative Activity Within Systems and Consortia; The Transformative Role of Undergraduate Research; Overview of CUR and the Promotion of Undergraduate Research; History, Scope, and Goals of CUR's "Institutionalizing Undergraduate Research" Workshop Program; 1996-2006: Building Capacity; 2006-2010: Regional Workshops; 2010-2014: Scaling-Up-System/Consortium Workshops |
Workshop DesignWorkshop Goals and Outcomes; Strategies Used: An Overview of the Volume; Chapter 2: The 30,000-Foot View From the National Association of System Heads and the Center for Inquiry in the Liberal Arts; Chapter 3: California State University System; Chapter 4: University of Wisconsin System; Chapter 5: Council of Public Liberal |
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Arts Colleges; Chapter 6: Pennsylvania State System of Higher Education; Chapter 7: City University of New York System; Chapter 8: Great Lakes Colleges Association; Chapter 9: Fostering Change at the System/Consortium Level; References |
2 The System Effect: Scaling High-Impact Practices Across CampusesIntroduction; An Overview of the Development of Higher Education Systems; Ongoing Environmental and Systemic Changes; The Implications of a Shifting Landscape for Systems; UR in System/Consortial Settings; Study of the Outcomes of CUR Professional Development for Systems/Consortia; System Profiles; Governance Implications for UR Change?; The Power to Convene; Declining or Stagnant Resources and Economic Growth; Cross-Cutting Themes for System/Consortial Change in UR; Models for System/Consortium Support of Institutionalizing UR |
Conclusions and ImplicationsReferences; 3 Undergraduate Research and Its Impact on Student Success for Underrepresented Students; The California State University System; Impact of Undergraduate Research on Underrepresented Student Success; Enhancing Undergraduate Research for Underrepresented Minorities Within the CSU; Support Programs; Quality Mentoring and Role Models; Funding for Students; Authentic Opportunities to Calibrate Knowledge; Societal Relevance and Community Engagement; Links From Community College; Curricular Enhancements |
Leveraging the System to Institutionalize Undergraduate Research Across the CSUFuture Directions; Body of Evidence; Developing a Sustainable Model to Support Undergraduate Research Systematically; Funding Faculty Engagement in Undergraduate Research; Leadership at the System Level; References; 4 Undergraduate Research and Economic Development: A Systems Approach in Wisconsin; Economic Development as a New Imperative for Higher Education; The Wisconsin Story: State-Level Strategies to Connect Undergraduate Research and Economic Development |
Undergraduate Research in the UW System: A Historical Overview |
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Sommario/riassunto |
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Undergraduate research is a high-impact practice that sparks students' interest in learning, and it improves retention, student success, graduation rates, and postgraduation achievement. Many individual campuses have offered these programs for several years, and the Council on Undergraduate Research (CUR) has partnered with state systems of higher education and public and private consortia to foster the institutionalization of undergraduate research. This volume illustrates many of the successes that entire systems/consortia and their campuses have achieved, such as: connecting undergradu |
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3. |
Record Nr. |
UNIORUON00016183 |
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Autore |
Musca, Giosuè |
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Titolo |
Carlo Magno ed Harun al Rashid / Giosuè Musca |
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Pubbl/distr/stampa |
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Descrizione fisica |
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Classificazione |
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Soggetti |
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Abbasidi - Rapporti con i Franchi |
ISLAM - STORIA - PERIODO ABBASIDE |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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