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1. |
Record Nr. |
UNINA9910460026503321 |
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Titolo |
Cell determination during hematopoiesis [[electronic resource] /] / Geoffrey Brown and Rhodri Ceredig, editors |
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Pubbl/distr/stampa |
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New York, : Nova Biomedical Books, c2009 |
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ISBN |
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Descrizione fisica |
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1 online resource (348 p.) |
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Collana |
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Cell biology research progress series |
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Altri autori (Persone) |
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BrownGeoffrey <1963-> |
CeredigRhodri |
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Disciplina |
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Soggetti |
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Hematopoiesis - Regulation |
Cell differentiation |
Genetic regulation |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Gene regulatory networks directing cell fates within the hematopoietic system / Damien Reynaud ... [et al.] -- Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors / Motonari Kondo, Thomas F. O'Brien and Anne Y. Lai -- Intracellular signaling for granulocytic and monocytic differentiation / George P. Studzinski and Ewa Marcinkowska -- Dendritic cell development, lineage issues and haematopoiesis at the single cell level / Shalin H. Naik -- The making and breaking of a B lymphocyte / Stephen L. Nutt -- Developmental pathways and molecular regulation of early T cell development in mouse and human / Tom Taghon -- Development of natural killer cell diversity / Christian A.J. Vosshenrich ... [et al.] -- Thymic epithelial cell development and function / Jason W. Gill -- The biology of lymphoid tissue inducer cells / Stephane Chappaz and Daniela Finke -- A pair-wise relationships model of hematopoietic fate determination / Geoffrey Brown ... [et al.] -- The epigenetics of haematopoiesis / Karen Brown. |
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2. |
Record Nr. |
UNINA9910137088203321 |
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Autore |
Petranel Theresa Ferrao |
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Titolo |
Cellular and phenotypic plasticity in cancer [[electronic resource] /] / edited by Petranel Theresa Ferrao, Andreas Behren, Robin Andersonand Erik Thompson |
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Pubbl/distr/stampa |
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Frontiers Media SA, 2015 |
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France : , : Frontiers Media SA, , 2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (77 pages) : illustrations |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Sommario/riassunto |
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The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of |
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speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies. |
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