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Record Nr. |
UNINA9910459795003321 |
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Titolo |
Inflammation in heart failure / / edited by Matthijs Blankesteijn, Raffaele Altara |
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Pubbl/distr/stampa |
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London, England : , : Academic Press, , 2015 |
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©2015 |
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ISBN |
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0-12-800485-1 |
0-12-800039-2 |
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Descrizione fisica |
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1 online resource (221 p.) |
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Disciplina |
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Soggetti |
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Heart failure - Diagnosis |
Inflammation - Alternative treatment |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front Cover; Inflammation in Heart Failure; Copyright; Contents; Contributors; Preface; Section 1: Pathophysiology of the Inflammatory Response in Heart Failure; Chapter 1: Inflammation in Heart Failure with Preserved Ejection Fraction; 1.1. Introduction; 1.2. Consequences of Limited Understanding of Pathophysiology in HFpEF; 1.3. Underlying Causes of HFpEF; 1.4. Adaptive Mechanisms in HFpEF; 1.5. Inflammation in HFpEF; 1.5.1. Inflammation in HFpEF Animal Studies; 1.5.1.1. Interactions with Other Systems; 1.5.2. Inflammation in HFpEF Human Studies |
1.6. Oxidative Stress, Endothelial Dysfunction and Microvascular Disease1.6.1. Potential Implications for Treatment of HFpEF; 1.7. Conclusions; References; Chapter 2: Role of the Innate Immune System in Ischemic Heart Failure; 2.1. Introduction; 2.2. Initiation of the Immune Response; 2.2.1. Receptors; 2.2.2. Complement; 2.2.3. Oxidative Stress; 2.2.3.1. ROS Generation Post- MI ; 2.2.3.2. Role of Oxidative Stress for Cardiac Necrosis and Inflammation; 2.2.4. Mechanical Stimuli; 2.3. Effectors of Innate Immunity; 2.3.1. Cytokines; 2.3.1.1. Cytokine Effects on Cardiomyocyte Survival |
2.3.1.2. Cytokines Influence Granulation Tissue Formation and Vascular |
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Remodeling Post-injury2.3.1.3. Cytokines Modulate Scar Tissue Formation After Injury; 2.3.1.4. Cytokines and ROS ; 2.3.1.5. Cytokines in Inflammation Resolution; 2.3.2. Cellular Effectors; 2.3.2.1. Leukocyte Recruitment; 2.3.2.2. Neutrophils; 2.3.2.2.1. Neutrophil-Mediated Cardiac Injury; 2.3.2.2.1.1. Reactive Oxygen Species; 2.3.2.2.1.2. Granule Toxicity; 2.3.2.3. Mononuclear Cells; 2.3.2.3.1. Monocytes; 2.3.2.3.2. Macrophages; 2.4. Reverse Remodeling |
2.5. Clinical Implications: Is There a Causal Link Between Dysequilibrated Inflammation and Remodeling?References; Chapter 3: The Role of Inflammation in Myocardial Infarction; 3.1. Introduction; 3.2. Role of the Inflammatory Response Before MI; 3.2.1. Development of the Atherosclerotic Plaque; 3.2.2. Immune Cells Involved; 3.2.3. Maturation and Rupture of the Atherosclerotic Plaque; 3.3. The Role of the Inflammatory Response in MI; 3.3.1. MI and Wound Healing; 3.3.2. Humoral Immune Response Post-MI; 3.3.2.1. Cytokines; 3.3.2.2. Chemokines; 3.3.3. Cellular Immune Response Post-MI |
3.3.3.1. Leukocytes3.3.3.2. Monocytes; 3.3.3.3. Macrophages; 3.3.3.4. Nonimmune Cells; 3.3.4. Other Factors Modulating the Immune Response Post-MI; 3.4. Inflammation as a Pharmacological and Biocellular Target; 3.4.1. Therapy Aimed at Inflammation Before MI; 3.4.1.1. Current Pharmacotherapy Targeting Inflammation Before MI; 3.4.1.1.1. Statins; 3.4.1.1.2. Hypoglycemic Agents; 3.4.1.1.3. Renin Angiotensin System Targeting; 3.4.1.1.4. P2Y 12 Receptor Inhibitors; 3.4.1.2. Novel Strategies Targeting Inflammation Before MI; 3.4.2. Therapy Aimed at Inflammation After MI |
3.4.2.1. Current Pharmacotherapy Targeting Inflammation After MI |
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Sommario/riassunto |
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Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details c |
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2. |
Record Nr. |
UNINA9910452596503321 |
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Autore |
Yong Kwek Ping |
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Titolo |
Due diligence in China [[electronic resource] ] : beyond the checklists / / Kwek Ping Yong |
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Pubbl/distr/stampa |
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ISBN |
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1-118-46905-4 |
1-118-63826-3 |
1-118-46904-6 |
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Edizione |
[1st edition] |
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Descrizione fisica |
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1 online resource (384 p.) |
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Collana |
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Disciplina |
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Soggetti |
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Negotiation in business - China |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Due Diligence in China: Beyond the Checklists; Copyright; Contents; Preface; Acknowledgments; Chapter 1: The Business Landscape in China; Macro and Structural Domains; From Planned Economy to Market Economy; Rising Income Inequality; Compensation Schemes in China; Corruption in China; U.S. Foreign Corrupt Practices Act; China's Own FCPA; Fraud; Company-Specific and Corporate Culture Issues; Conducting Due Diligence in China versus Western Countries; Conclusion; Notes; Chapter 2: Due Diligence in China; Due Diligence for Different Types of Deals |
Private Equity and Mergers and Acquisition Due DiligencePre-IPO Due Diligence; Levels of Due Diligence; Initial Due Diligence; Advanced Due Diligence; Full Due Diligence; Key Considerations; Motivations for the Deal; Identify the Specific Element Wanted in the Deal; Identify Potential Synergies and Liabilities; Establish the Value of the Target; Identify Deal Breakers; Organization of Due Diligence Process; Stages of Due Diligence; Intensity of Due Diligence; The Due Diligence Team; Independence of Vendor Due Diligence; Reasons for Poor Due Diligence; Selection of Service Providers |
Lack of ResourcesRushing the Deal; Poor Planning; Overdependence on Checklists; Poor Risk Mitigation; Poor Alignment of Interests; Reverse Takeovers; Dispute between SEC and CSRC; Conclusion; Notes; Chapter |
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3: Financial Due Diligence; Financial Due Diligence Checklist; Major Differences between China and Developed Countries; The Approach; Information Collection Process; Sales; Cost of Sales; Expenses; Cash; Other Payables and Other Receivables; Fixed Tangible and Intangible Assets; Accounting Information Systems; Tax Issues and Preferential Tax Policies toward Hi-Tech Enterprises |
Other Local PoliciesInternal Controls Systems; Important Points to Note; Conclusion; Notes; Chapter 4: Operational, Commercial, Legal, and Other Due Diligence; Operational Due Diligence; Management and Employees; Information Technology Systems; Business Operations; Supply-Chain Management; Commercial Due Diligence; Industry Outlook; PEST Analysis; Legal Due Diligence; Setting the Right Attitude and Mentality; Uncovering Potential Liabilities; Intellectual Property Protection (IP); Management of Company Stamps; Balanced Scorecard (BSC); How to Predict Bankruptcy-Altman Z Scores and Gearing |
Optional ChecklistsHuman Resource Due Diligence; Sales and Marketing Due Diligence; Culture Due Diligence; Environmental Due Diligence; Conclusion; Notes; Chapter 5: Beyond the Checklists: Founder and Management; Founder Management Root; The Founder Background Check; Other Business Holdings; Multiple and "Missing" Identities; Personal Life of the Founder; Guanxi (Relationship); Due Diligence on More Than One Founder; Summary of Background Check: SWOPEST and Tri-Background; The SWOPEST Framework; The Tri-Background Venn Framework; Conclusion; Notes; Chapter 6: Beyond the Checklists: Hard Facts |
Face-to-Face Meetings |
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Sommario/riassunto |
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A plain-English guide that demystifies the business landscape in China from a due diligence point of view Due diligence is crucial to any business deal, and, thankfully, due diligence research has come a long way over the years. What used to be a cumbersome, time-consuming process has been standardized and systemized with generally accepted auditing frameworks and tools, such as the all-important auditing ""checklists."" But when it comes to doing due diligence in China, with its opaque regulatory system and byzantine accounting standards, all bets are off. In this book an acknowledge |
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