Pharmaceutical amorphous solid dispersions / / edited by Ann Newman, Seventh Street Development Group Lafayette, Indiana, USA ; contributors, Patrick Augustijns [and forty seven others]

• Record Nr.: UNINA9910459699603321
• Pubbl/distr/stampa: Hoboken, New Jersey : , : Wiley, , 2015; ©2015
• ISBN: 1-118-90141-X; 1-118-90138-X
• Descrizione fisica: 1 online resource (1218 p.)
• Disciplina: 615.7
• Soggetti: Pharmaceutical technology; Absorption; Solubility; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Cover; Title Page; Copyright; Dedication; Preface; Contributors; 1.1 Introduction; 1.2 Formation of the Amorphous State and the Glass Transition Temperature; 1.3 Structure of Amorphous Solids; 1.4 Molecular Mobility in Amorphous Solids; 1.5 Solid-State Crystallization from the Amorphous State; 1.6 Supersaturation of API in Aqueous Media from the Amorphous State; 1.7 Mixtures of Amorphous Solids; 1.8 Formation and Properties of Amorphous Solid Dispersions; 1.9 Solid-State Crystallization from Amorphous Dispersions; 1.10 Dissolution and Supersaturation of API from Amorphous Solid Dispersions; 1.11 Pharmaceutical Development of Amorphous Solid DispersionsReferences; Chapter 1: Introduction to Amorphous Solid Dispersions; 2.1 Polymers Commonly Used in Amorphous Solid Dispersions; 2.2 Surfactants Commonly Used in Solid Dispersions; 2.3 Synergies between Surfactants and Polymers in Solid Dispersion Systems; 2.4 Physical Properties of Materials and Considerations in ; Designing Solid Dispersions; References; Chapter 2: Polymers and Surfactants; 3.1 Introduction; 3.2 Amorphous Dispersion Screening; 3.3 Amorphous Solid Dispersion Selection; 3.4 Case Study; 3.5 Conclusions; References; Chapter 3: Amorphous Solid Dispersion Screening4.1 Introduction; 4.2 Thermal Analysis Methods; 4.3 Dielectric Relaxation Methods; 4.4 Moisture Sorption Methods; 4.5 Vibrational Spectroscopy and Microspectroscopy; 4.6 Solid-State NMR Spectroscopy; 4.7 Other Molecular Spectroscopic Methods; 4.8 X-Ray Diffractometry; 4.9 Microscopic and Surface Analysis Methods; 4.10 Other Emerging Analytical Methods; 4.11 Computational Models; 4.12 Conclusions; Acknowledgments; References; Chapter 4: Solid-State Characterization of Amorphous Dispersions; 5.1 Introduction; 5.2 Theory of Crystallization in the Solid State5.3 Factors Impacting the Crystallization Tendency of Active Pharmaceutical Compounds; 5.4 Role of Additives in Modifying Solid-State Crystallization; 5.5 Assessment of Physical Stability; 5.6 Crystallization in Aqueous Environments; 5.7 Summary and Outlook; References; Chapter 5: Physical Stability and Crystallization Inhibition; 6.1 Solubility and Dissolution: An Overview; 6.2 Differences Between Crystalline API, Amorphous Materials, and Amorphous Dispersions as it Pertains to Solubility and Dissolution; 6.3 The Relationship of Polymer Properties with Solubility, Dissolution, and Supersaturation6.4 Solubility and Dissolution Factors to Consider for Dispersions; 6.5 Solubility and Dissolution Measurements for Amorphous Dispersions: Summary, Conclusions, and Recommendations; Acknowledgments; References; Chapter 6: Solubility and Dissolution Considerations for Amorphous Solid Dispersions; 7.1 Introduction: Translational Drug Development; 7.2 Translational Development at the Discovery Stage; 7.3 Translational Development After Discovery; 7.4 Conclusions; References; Chapter 7: Translational Development of Amorphous Dispersions
• Sommario/riassunto: Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology - a leading platform to deliver poorly water soluble drugs, a major hurdle in today's pharmaceutical industry. Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations Has an appendix with structure and property information for polymers commonly used in drug developm