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Record Nr. |
UNINA9910459189503321 |
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Titolo |
Multiple testing problems in pharmaceutical statistics / / editors, Alex Dmitrienko, Ajit C. Tamhane, Frank Bretz |
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Pubbl/distr/stampa |
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Boca Raton : , : Chapman & Hall/CRC/Taylor & Francis, , 2010 |
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ISBN |
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0-429-19186-3 |
1-282-90323-3 |
9786612903236 |
1-58488-985-3 |
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Descrizione fisica |
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1 online resource (323 p.) |
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Collana |
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Chapman & Hall/CRC biostatistics series ; ; 33 |
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Altri autori (Persone) |
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DmitrienkoAlex |
TamhaneAjit C |
BretzFrank |
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Disciplina |
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Soggetti |
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Drugs - Testing - Statistical methods |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover; Title; Copyright; Contents; Preface; List of Contributors; Chapter 1: Multiplicity Problems in Clinical Trials: A Regulatory Perspective; Chapter 2: Multiple Testing Methodology; Chapter 3: Multiple Testing in Dose-Response Problems; Chapter 4: Analysis of Multiple Endpoints in Clinical Trials; Chapter 5: Gatekeeping Procedures in Clinical Trials; Chapter 6: Adaptive Designs and Confirmatory Hypothesis Testing; Chapter 7: Design and Analysis of Microarray Experiments for Pharmacogenomics; Bibliography; Index |
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Sommario/riassunto |
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Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clin |
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