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1. |
Record Nr. |
UNINA9910459023403321 |
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Autore |
Kisaalita William Ssempa <1953, > |
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Titolo |
3D cell-based biosensors in drug discovery programs : microtissue engineering for high throughput screening / / William S. Kisaalita |
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Pubbl/distr/stampa |
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Boca Raton [Fla.] : , : CRC Press, , 2010 |
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ISBN |
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0-429-14677-9 |
1-4200-7350-8 |
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Descrizione fisica |
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1 online resource (392 p.) |
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Disciplina |
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Soggetti |
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Pharmaceutical biotechnology |
Biosensors |
High throughput screening (Drug development) |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front Cover; Dedication; Contents; Preface; Author; Part I. Introduction; Chapter 1. Biosensors and Bioassays; Chapter 2. Target-Driven Drug Discovery; Part II. 3D versus 2D Cultures; Chapter 3. Comparative Transcriptional Profiling and Proteomics; Chapter 4. Comparative Structure and Function; Part III. Emerging Design Principles; Chapter 5. Chemical Microenvironmental Factors; Chapter 6. Spatial and Temporal Microenvironmental Factors; Chapter 7. Material Physical Property and Force Microenvironmental Factors; Chapter 8. Proteomics as a Promising Tool in the Search for 3D Biomarkers |
Chapter 9. Readout Present and Near FutureChapter 10. Ready-to-Use Commercial 3D Plates; Part IV. Technology Deployment Challenges and Opportunities; Chapter 11. Challenges to Adopting 3D Cultures in HTS Programs; Chapter 12. Cases for 3D Cultures in Drug Discovery; Chapter 13. Ideal Case Study Design; Appendix A: Patents for 3D Scaffolds; Appendix B: Current Drug Targets; Appendix C: Popular Cell Lines in Drug Discovery; Appendix D: Stem Cells in Drug Discovery; Back Cover |
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Sommario/riassunto |
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This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has |
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developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information--Provided by publisher. |
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2. |
Record Nr. |
UNINA9910973608403321 |
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Autore |
Gurney John <1960-> |
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Titolo |
Gerrard Winstanley : te Digger's life and legacy / / John Gurney |
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Pubbl/distr/stampa |
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London ; ; New York, : Pluto Press, 2013 |
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ISBN |
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Descrizione fisica |
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1 online resource (viii, 162 pages ) : illustrations (black and white) |
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Collana |
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Disciplina |
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Soggetti |
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Levellers |
Radicalism - Great Britain - History |
Great Britain History Puritan Revolution, 1642-1660 |
Great Britain |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction -- The Making of the Digger -- Winstanley the Digger -- A New Beginning? -- Winstanley's Legacy. |
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Sommario/riassunto |
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Reveals the hidden history of a great radical Briton - a Christian communist, and leader of the Diggers movement. |
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