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1. |
Record Nr. |
UNINA9910458943503321 |
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Titolo |
Preclinical development handbook ADME and biopharmaceutical properties [[electronic resource] /] / [edited by] Shayne Cox Gad |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley-Interscience, c2008 |
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ISBN |
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1-281-23741-8 |
9786611237417 |
0-470-24903-X |
0-470-24902-1 |
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Descrizione fisica |
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1 online resource (1347 p.) |
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Collana |
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Pharmaceutical Development Series ; ; v.3 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Pharmacokinetics |
Drug development |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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PRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration |
10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug |
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Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions |
23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies |
33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; Index |
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Sommario/riassunto |
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A clear, straightforward resource to guide you through preclinical drug developmentFollowing this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.Each chapter is written by one or more leadin |
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2. |
Record Nr. |
UNINA9910462154903321 |
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Autore |
Suares Peter |
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Titolo |
The Kyoto School's takeover of Hegel [[electronic resource] ] : Nishida, Nishitani, and Tanabe remake the philosophy of spirit / / Peter Suares |
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Pubbl/distr/stampa |
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Lanham, Md., : Lexington Books, c2011 |
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ISBN |
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1-283-65727-9 |
1-4616-3439-3 |
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Descrizione fisica |
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1 online resource (234 p.) |
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Disciplina |
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Soggetti |
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Philosophy, Japanese |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 195-211) and index. |
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Nota di contenuto |
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Nishida -- Nishitani -- Tanabe -- The Danish parallel -- Conclusion. |
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Sommario/riassunto |
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The Kyoto School grafts the presuppositions and methodology of Hegel's idealism onto the Japanese Buddhist worldview. In The Kyoto School's Takeover of Hegel, Peter Suares evaluates the success of the three principal figures of the School-Nishida Kitaro, Tanabe Hajime, and Nishitani Keiji-in integrating these dissimilar ideas into a coherent religious philosophy. |
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3. |
Record Nr. |
UNISA996466140903316 |
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Titolo |
Cooperative Information Systems [[electronic resource] ] : 7th International Conference, CoopIS 2000 Eilat, Israel, September 6-8, 2000 Proceedings / / edited by Opher Etzion, Peter Scheuermann |
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Pubbl/distr/stampa |
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Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2000 |
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ISBN |
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Edizione |
[1st ed. 2000.] |
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Descrizione fisica |
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1 online resource (XII, 340 p.) |
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Collana |
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Lecture Notes in Computer Science, , 0302-9743 ; ; 1901 |
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Disciplina |
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Soggetti |
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Database management |
Data structures (Computer science) |
Computer engineering |
User interfaces (Computer systems) |
Computer communication systems |
Information storage and retrieval |
Database Management |
Data Structures and Information Theory |
Computer Engineering |
User Interfaces and Human Computer Interaction |
Computer Communication Networks |
Information Storage and Retrieval |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Workflow Modeling -- Formalizing (and Reasoning about) the Specifications of Workflows -- Advanced Workflow Patterns -- Extending UML with Workflow Modeling Capabilities -- Information Retrieval -- ConSearch: Using Hypertext Contexts as Web Search Boundaries -- Combining the Power of Searching and Querying -- Cooperative Indexing, Classification, and Evaluation in BoW -- Cooperative Databases -- Complex View Selection for Data Warehouse Self-Maintainability -- Integrating Snapshot Isolation into Transactional Federations -- An Evaluation of the Java-Based Approaches to Web |
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Database Access -- Short Presentations -- A Framework for ASP-Marketplaces -- Exploring the Semantic Structure of Technical Document Collections: A Cooperative Systems Approach -- Organized Distributed Systems -- Managing Aging Data Using Persistent Views -- A Workflow System through Cooperating Agents for Control and Document Flow over the Internet -- Distributed View Expansion in Composable Mediators -- Information Services -- eResponder: Electronic Question Responder -- Efficient Matching for Web-Based Publish/Subscribe Systems -- A Software Retrieval Service Based on Knowledge-Driven Agents -- Workflow Execution -- Benchmarking and Configuration of Workflow Management Systems -- Workflow Modeling using Proclets -- Dealing with Logical Failures for Collaborating Workflows -- CSCW and Organizational Aspects -- A Negotiation Model for CSCW -- The Organizational Memory Information System PRINCE -- An Extensible Business Communication Language -- Mobile Cooperation -- Exploiting the Features of Asymmetry for Query Processing in a Mobile Computing Environment -- Data Lockers: Mobile-Agent Based Middleware for the Security and Availability of Roaming Users Data -- A Java Framework for Mobile Data Synchronization -- Multi Agents Systems -- Dynamic Pricing with Limited Competitor Information in a Multi-Agent Economy -- Multi-agent Cooperative Transactions for E-Commerce -- Cross-Organizational Transaction Support for Virtual Enterprises. |
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Sommario/riassunto |
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Cooperation among systems has gained substantial importance in recent years: electronic commerce virtual enterprises and the middleware paradigm are just some examples in this area. CoopIS is a multi-disciplinary conference, which deals with all aspects of cooperation. The relevant disciplines are: collaborative work, distributed databases, distributed computing, electronic commerce, human-computer interaction, multi-agent systems, information retrieval, and workflow systems. The CoopIS series provides a forum for well-known researchers who are drawn by the stature and the tradition of these conference series and has a leading role in shaping the future of the cooperative information systems area. CoopIS 2000 is the seventh conference in the series and the fifth conference organized by the International Foundation on Cooperative Information Systems (IFCIS). It is sponsored by the IFCIS, the IBM Research Laboratory in Haifa and Compaq, Tandem labs Israel. It replaces the former international workshops on Interoperability in Multidatabase systems (IMS) and the conference series on Cooperative Information Systems (CoopIS & ICICIS). In response to the call for papers 74 papers were submitted. Each of them was reviewed by at least three reviewers, and at the end of this process 24 papers were accepted for presentation at the conference. Six additional papers were selected for short presentations. In addition the conference includes two panels, two keynote speakers (Professor Calton Pu from Georgia Tech and Professor Sheizaf Rafaeli from Haifa University) and one tutorial. A special issue of the International Journal of Cooperative Information Systems will follow. August 2000 Opher Etzion & Peter Scheuermann. |
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