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Record Nr. |
UNINA9910458653103321 |
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Titolo |
The immune synapse as a novel target for therapy [[electronic resource] /] / Luis Graca, editor |
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Pubbl/distr/stampa |
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Basel, : Birkhäuser, c2008 |
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ISBN |
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1-281-14091-0 |
9786611140915 |
3-7643-8296-1 |
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Edizione |
[1st ed. 2008.] |
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Descrizione fisica |
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1 online resource (203 p.) |
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Collana |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Immune response - Molecular aspects |
Immune response - Regulation |
Synapses |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Progress in inflammation research". |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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The immune synapse and T cell activation: regulation by chemokines -- The induction of regulatory T cells by targeting the immune synapse -- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology -- Targeting CD4 for the induction of dominant tolerance -- Anti-CD3: from T cell depletion to tolerance induction -- Immune modulation by CD40L blockade -- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance -- Adhesion molecules as therapeutic targets -- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within? -- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells -- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance -- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic. |
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Sommario/riassunto |
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The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of |
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information across the T cell–APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area. |
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2. |
Record Nr. |
UNINA9910846984503321 |
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Autore |
Siller Georg |
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Titolo |
Unsicheres Mitleid : Eine Begriffssuche im Ausgang von Wittgenstein / Georg Siller |
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Pubbl/distr/stampa |
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Bielefeld, : transcript Verlag, 2018 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (262 pages) |
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Collana |
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Edition Moderne Postmoderne |
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Classificazione |
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Disciplina |
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Soggetti |
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Mitleid; Emotion; Respekt; Philosophie der Emotionen; Wittgenstein; Aspektwahrnehmung; Aristoteles; Friedrich Nietzsche; Bertolt Brecht; Hannah Arendt; Sozialität; Ethik; Philosophiegeschichte; Analytische Philosophie; Sozialphilosophie; Philosophie; Compassion; Feeling; Respect; Philosophy of Emotions; Aspect-Perception; Aristotele; Social Relations; Ethics; History of Philosophy; Analytical Philosophy; Social Philosophy; Philosophy |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Frontmatter 1 Inhalt 5 Einleitung 9 1. Die Familienähnlichkeit von »Mitleid« 17 2. Varianten der Zuschreibung 83 3. Das Mitleid in der Neuropsychologie 159 4. Irritiertes Mitleid 183 Resümee 239 Danksagung 249 Literatur 251 |
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Sommario/riassunto |
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Wie kaum ein anderes Gefühl ist Mitleid von Unsicherheiten geprägt: Der Begriff »Mitleid« wird widersprüchlich verwendet - aber auch das Gefühl selbst kann schwanken. Dies wirft Fragen der Angemessenheit auf. Georg Sillers genaue Lektüre Ludwig Wittgensteins zeigt, dass solche Unbestimmtheiten jedoch nicht als Defizite gesehen werden müssen: Erstens sind psychologische Begriffe in ihrer Bedeutungsvielfalt Teil unserer Lebensform und damit mehr als die Bezeichnung von Zuständen, zweitens stellt schwankendes Mitleid eine ganz eigene Haltung dar - und zwar häufig die des Respekts. Diese Perspektive ermöglicht neue Zugriffe auf Aristoteles, Nietzsche, Brecht, Arendt sowie die Neuropsychologie - und nicht zuletzt auf Wittgenstein selbst. |
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