Stress and addiction [[electronic resource] ] : biological and psychological mechanisms / / edited by Mustafa al'Absi

• Record Nr.: UNINA9910458620303321
• Pubbl/distr/stampa: Amsterdam ; ; Boston, : Academic Press, c2007
• ISBN: 1-281-02327-2; 9786611023270; 0-08-052529-6
• Descrizione fisica: 1 online resource (453 p.)
• Altri autori (Persone): AbsiMustafa al
• Disciplina: 616.86
• Soggetti: Drug abuse - Physiological aspects; Stress (Psychology) - Physiological aspects; Drug abuse - Psychological aspects; Stress (Psychology); Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Front Cover; Stress and Addiction: Biological and Psychological Mechanisms; Copyright Page; Contents; Contributors; Foreword; Preface; Acknowledgments; SECTION I: NEUROBIOLOGY OF STRESS AND ADDICTION; Chapter 1. Biological Bases of the Stress Response; I. Introduction; II. Physiological Stress Research; III. Major Components of the Biological Stress Response System; IV. Other Stress-Responsive Hormone Axes; V. Other Stress-Responsive Systems; VI. Final Remarks; References; Chapter 2. The Hypothalamic-Pituitary-Adrenal Axis and Addiction; I. Introduction; II. Stress and the HPA Axis; III. Stress, the HPA Axis, and the Acquisition of Drug TakingIV. Stress and Vulnerability to Addiction in Humans; V. The HPA Axis and the Maintenance of Drug Taking; VI. Relapse to Addiction; VII. Inconsistencies; VIII. Conclusions and Implications for the Treatment of Addiction; References; Chapter 3. Dopaminergic Reward Pathways and Effects of Stress; I. Defining Stress; II. The Mesencephalic Dopamine System; III. Dopamine and Addiction; IV. Dopamine and Stress; V. Conclusions; References; Chapter 4. Endogenous Opiates, Addiction, ; and the Stress Response; I. Introduction; II. The Endogenous Opioid SystemIII. The Endogenous Opioid System and Reward and Reinforcement; IV. Effect of Alcohol on Endogenous Opioid Activity; V. Effect of Alcohol on Endogenous Opioid Receptors; VI. Endogenous Opioid Activity and Receptors and Alcohol Preference; VII. Opioid Antagonists in the Treatment of Alcohol Addiction; VIII. Endogenous Opioid Activity and Receptors and Cocaine Preference; IX. Opioid Antagonists in the Treatment of Cocaine Addiction; X. Opioids and Risk for Alcoholism; XI. The μ-Opioid Receptor Gene; XII. Conclusions; References; Chapter 5. Early Life Stress and Vulnerability to AddictionI. Introduction; II. Neurohormonal Mechanisms of Stress Relevant to Cocaine Addiction; III. Animal Models; IV. Neurohormonal Effects of Neonatal Isolation; V. Behavioral Effects of Neonatal Isolation; VI. Sex Differences and Estrous Stage Effects of Neonatal Isolation; VII. Maternal Care Hypothesis; VIII. Conclusions and Translation for Clinical Relevance; References; Chapter 6. Genetics, Stress, and the Risk for Addiction; I. Introduction; II. The Extent of the Problem: Prevalence of Addiction; III. Heritability of Addiction; IV. HPA AxisV. The "Reward" Pathway of Addiction: Interaction with Stress; VI. Reward Pathway and Stress Response: Key Neurotransporter Systems; VII. Limbic Regulation of Response to Stress; VIII. The Locus Coeruleus (LC)-Norepinephrine (NE) System; IX. Conclusions; References; Chapter 7. Neurobiology of Stress and Risk for Relapse; I. Overview; II. Animal Models for Studying the Effects of Stress on Relapse to Drug Seeking: The Reinstatement Procedure; III. The Neurobiology of Stress-Induced Reinstatement of Drug Seeking; IV. Long-Lasting Changes in the Responsivity of the Central Nervous System to CRF: Behavioral and Neuroanatomical Studies with Potential Implications for Reinstatement
• Sommario/riassunto: Stress is one of the most commonly reported precipitants of drug use and is considered the number one cause of relapse to drug abuse. For the past several decades, there have been a number of significant advances in research focusing on the neurobiological and psychosocial aspects of stress and addiction; along with this growth came the recognition of the importance of understanding the interaction of biological and psychosocial factors that influence risk for initiation and maintenance of addictive behaviors. Recent research has started to specifically focus on understanding the nature of how