A pharmacology primer [[electronic resource] ] : theory, applications, and methods / / Terry Kenakin

• Record Nr.: UNINA9910458609303321
• Autore: Kenakin Terrence P
• Pubbl/distr/stampa: Burlington, MA ; ; London, : Academic Press, c2006
• ISBN: 1-280-70765-8; 9786610707652; 0-08-046530-7
• Edizione: [2nd ed.]
• Descrizione fisica: 1 online resource (319 p.)
• Disciplina: 615.1; 615/.7
• Soggetti: Pharmacology; Drugs; Chemicals - Physiological effect; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Previous ed.: London: Elsevier, 2004.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Front cover; A PHARMACOLOGY PRIMER THEORY, APPLICATION, AND METHODS; Copyright page; Foreword to Second Edition; Foreword to First Edition; Table of contents; Chapter 1. What Is Pharmacology?; 1.1 About This Book; 1.2 What Is Pharmacology?; 1.3 The Receptor Concept; 1.4 Pharmacological Test Systems; 1.5 The Nature of Drug Receptors; 1.6 Pharmacological Intervention and the Therapeutic Landscape; 1.7 System-independent Drug Parameters: Affinity and Efficacy; 1.8 What Is Affinity?; 1.9 The Langmuir Adsorption Isotherm; 1.10 What Is Efficacy?; 1.11 Dose-response Curves; 1.12 Chapter Summary and Conclusions1.13 Derivations: Conformational Selections as a Mechanism of Efficacy; References; Chapter 2. How Different Tissues Process Drug Response; 2.1 Drug Response as Seen Through the ''Cellular Veil''; 2.2 The Biochemical Nature of Stimulus-response Cascades; 2.3 The Mathematical Approximation of Stimulus-response Mechanisms; 2.4 System Effects on Agonist Response: Full and Partial Agonists; 2.5 Differential Cellular Response to Receptor Stimulus; 2.6 Receptor Desensitization and ; Tachyphylaxis; 2.7 The Measurement of Drug Activity; 2.8 Advantages and Disadvantages of Different Assay Formats2.9 Drug Concentration as an Independent Variable; 2.10 Chapter Summary and Conclusions; 2.11 Derivations; References; Chapter 3. Drug-Receptor Theory; 3.1 About This Chapter; 3.2 Drug-Receptor Theory; 3.3 The Use of Mathematical Models in Pharmacology; 3.4 Some Specific Uses of Models in Pharmacology; 3.5 Classical Model of Receptor Function; 3.6 The Operational Model of Receptor Function; 3.7 Two-state Theory; 3.8 The Ternary Complex Model; 3.9 The Extended Ternary Model; 3.10 Constitutive Receptor Activity; 3.11 The Cubic Ternary Complex Model3.12 Chapter Summary and Conclusions; 3.13 Derivations; References; Chapter 4. Pharmacological Assay Formats: Binding; 4.1 The Structure of This Chapter; 4.2 Binding Theory and Experiment; 4.3 Complex Binding Phenomena: Agonist Affinity from Binding Curves; 4.4 Experimental Prerequisites for Correct Application of Binding Techniques; 4.5 Chapter Summary and Conclusions; 4.6 Derivations; References; Chapter 5. Agonists: The Measurement of Affinity and Efficacy in Functional Assays; 5.1 Functional Pharmacological Experiments; 5.2 The Choice of Functional Assays5.3 Recombinant Functional Systems; 5.4 Functional Experiments: Dissimulation in Time; 5.5 Experiments in Real Time Versus Stop Time; 5.6 The Measurement of Agonist Affinity in Functional Experiments; 5.7 Estimates of Relative Efficacy of Agonists in Functional Experiments; 5.8 Chapter Summary and Conclusions; 5.9 Derivations; References; Chapter 6. Orthosteric Drug Antagonism; 6.1 Introduction; 6.2 Kinetics of Drug-Receptor Interaction; 6.3 Surmountable Competitive Antagonism; 6.4 Noncompetitive Antagonism; 6.5 Agonist-Antagonist Hemi-equilibria; 6.6 Resultant Analysis
• Sommario/riassunto: The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.*Over 30 new figures and tables*More human interest information to provide readers with historical facts on pharmacology research*New section on therapeutics to help identify diseases and drug treatments*New section on new biological concepts relevant to pharmacological researc