Chemistry of protein and nucleic acid cross-linking and conjugation / / Shan S. Wong, David M. Jameson

• Record Nr.: UNINA9910457792103321
• Autore: Wong Shan S.
• Pubbl/distr/stampa: Boca Raton : , : CRC Press, , 2012
• ISBN: 0-429-12723-5; 1-283-34975-2; 9786613349750; 1-4200-0764-5
• Edizione: [2nd ed.]
• Descrizione fisica: 1 online resource (608 p.)
• Altri autori (Persone): JamesonDavid M; WongShan S
• Disciplina: 572/.633
• Soggetti: Proteins - Crosslinking; Nucleic acids - Structure; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Rev. ed. of: Chemistry of protein conjugation and cross-linking. c1991.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Front Cover; Contents; Preface; Authors; Chapter 1: Overview of Protein Conjugation; Chapter 2: Review of Protein and Nucleic Acid Chemistry; Chapter 3: Reagents Targeted to Specific Functional Groups; Chapter 4: How to Design and Choose Cross-Linking Reagents; Homobifunctional Cross-Linking Reagents; Chapter 6: Heterobifunctional Cross-Linkers; Chapter 7: Multifunctional Cross-Linking Reagents; Chapter 8: Monofunctional and Zero -Length Cross -Linking Reagents; Chapter 9: General Approaches for Chemical Cross-Linking; Chapter 10: Analysis of Cross-Linked Products; Chapter 11: Applications of Chemical Cross-Linking to the Study of Biological MacromoleculesChapter 12: Applications of Chemical Conjugation in the Preparation of Immunoconjugates and Immunogens; Chapter 13: Application of Chemical Conjugation for the Preparation of Immunotoxins and Other Drug Conjugates for Targeting Therapeutics; Chapter 14: Application of Chemical Conjugation to Solid-State Chemistry; Appendix A Amino Group-Directed Homobifunctional Cross-Linkers; Appendix B Sulfhydryl Group-Directed ; Homobifunctional Cross-Linkers; Appendix C Phenolate- and Imidazolyl-Group-Directed Reagents: Bisdiazonium PrecursorsAppendix D Group Selective Heterobifunctional Cross-Linkers; Appendix E Photoactivatable Heterobifunctional Cross-Linking Reagents; Back Cover
• Sommario/riassunto: Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivit