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1. |
Record Nr. |
UNINA9910457252903321 |
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Titolo |
Advances in antiviral drug design . Volume 5 [[electronic resource] /] / editor, E. De Clercq |
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Pubbl/distr/stampa |
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Greenwich, CT ; ; London, England, : Jai Press, 2007 |
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ISBN |
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1-281-11983-0 |
9786611119836 |
0-08-054824-5 |
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Descrizione fisica |
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1 online resource (265 p.) |
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Collana |
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Advances in antiviral drug design ; ; 5 |
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Altri autori (Persone) |
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Disciplina |
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616.9 |
616.9/25061/05 |
616.91061 |
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Soggetti |
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Antiviral agents |
Anti-infective agents |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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I. IntroductionII. Design; III. Synthesis; IV. Antiviral activity; Acknowledgements; References; Chapter 4. Synthesis and antiviral evaluation of broad spectrum, orally active analogs of cidofovir and other acyclic nucleoside phosphonates; I. Introduction; II. Synthesis of hexadecyloxypropyl and related esters of cidofovir; III. Antiviral evaluation and spectrum of activity; IV. Structure activity relationships; V. Cellular metabolism; VI. Oral pharmacokinetics and tissue distribution; VII. Antiviral activity in animal models of viral diseases |
VIII. Alkoxyalkyl esters of (S)-HPMPA and other acyclic nucleoside phosphonatesIX. Conclusions; Acknowledgements; References; Chapter 5. CCR5 antagonistsCCR5 antagonists for the treatment ofHIV infection and AIDS; I. Introduction; II. Inhibition of HIV entry; III. CCR5 as a drug target; IV. The discovery of novel CCR5 antagonists; V. Molecular mechanisms; VI. Resistance to CCR5 antagonists in vitro and in the clinic; VII. Conclusions; References; Chapter 6. The medicinal chemistry of the DATADATA and DAPYDAPY series of HIV-1HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIsNNRTIs) |
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AbstractI. Introduction; II. The diaryltriazine (DATA) series; III. The diarylpyrimidine (DAPY) series; IV. Conclusion; Acknowledgements; References; Index |
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Sommario/riassunto |
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Regularly reviewing the ""state-of-the-art"" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use. |
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2. |
Record Nr. |
UNISA996198972503316 |
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Titolo |
Advances in SiC / SiC ceramic composites : developments and applications in energy systems, ceramic transactions / / edited by Kohyama, Akira [and three others] |
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Pubbl/distr/stampa |
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Westerville, Ohio : , : The American Ceramic Society, , 2002 |
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©2002 |
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ISBN |
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1-118-40602-8 |
1-118-40601-X |
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Descrizione fisica |
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1 online resource (390 p.) |
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Collana |
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Ceramic Transactions Series ; ; Volume 144 |
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Disciplina |
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Soggetti |
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Silicon carbide |
Ceramic materials |
Composite materials |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Advanced SiC/SiC Ceramic Composites: Developments and Applications in Energy Systems; Contents; Preface; Processing for SiC/SiC Composites; Overview of CREST-ACE Program for SiC/SiC Ceramic Composites and Their Energy System Applications; Processing of SiC/SiC Fibrous Composites According to CVI-Techniques; Research on the High Performance Silicon Carbide Ceramics and Silicon Carbide Based Composites; Optimization and Characterization of Chemical |
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Vapor Infiltrated SiC/SiC Composites |
Optimizing the Fabrication Process for Excellent Mechanical Properties in Stoichiometric SiC Fiber/FCVI SiC Matrix CompositesA Novel Processing Technique of Silicon Carbide-Based Ceramic Composites for High Temperature Applications; Facile Fabrication of SiC Matrix Composites Using Novel Preceramic Polymers; Process Design for SiC/SiC Composite with Polymeric Precursor; Matrix Filling Behavior of SiC/SiC Composite by Whiskering and the CVI Process; Development of SiC/SiC Composites by the Melt Infiltration Process; Processing for SiC/SiC Composite Constituent |
Mechanical,Thermochemical, and Microstructural Characterization of AHPCS-Derived SiCPolysilane-Based Precursors for SiC/SiC Composites; Present Status and Future Trends on the Development and Application of Continuous SiC Fibers; Properties of BN Coating on SiC Fiber by the Continuous CVD Process; SiC Ceramic Fibers Synthesized from Polycarbosilane-Polymethylsilane Polymer Blends; Effect of Residual Silicon Phase on Reaction-Sintered Silicon Carbide; Characterization of Thermomechanical Performance; Development of Test Standards for Continuous Fiber Ceramic Composites in the United States |
Effects of Interlayers on Interfacial Shear Strength and Flexural Properties of Tyranno-SA Fiber-Reinforced CVI-SiC/SiC CompositesFlexural Properties of Several SiC Fiber-Reinforced CVI-SiC Matrix Composites; A Finite-Element Analysis of the Thermal Diffusivity/Conductivity of SiC/SiC Composites; Microstructure Evolution in Highly Crystalline SiC Fiber Under Applied Stress Environments; Joining Technologies and Advanced Energy Applications; High Temperature Brazing for SiC and SiCf/SiC Ceramic Matrix Composites; Joining SiC-Based Ceramics and Composites with Preceramic Polymers |
Modeling of Fracture Strength of SiC/SiC Composite Joints by Using Interface Elements |
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