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Record Nr. |
UNINA9910457200303321 |
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Autore |
Bright William <1928-2006.> |
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Titolo |
1500 California place names [[electronic resource] ] : their origin and meaning / / William Bright |
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Pubbl/distr/stampa |
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Berkeley, : University of California Press, c1998 |
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ISBN |
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1-280-08577-0 |
9786613520289 |
0-520-92054-6 |
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Descrizione fisica |
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1 online resource (175 p.) |
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Altri autori (Persone) |
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GuddeErwin Gustav <1889-1969.> |
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Disciplina |
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Soggetti |
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Names, Geographical - California |
Electronic books. |
California History, Local |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"A revised version of 1000 California place names, by Erwin G. Gudde, third edition." |
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Nota di contenuto |
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Front matter -- Preface -- Key to Pronunciation -- 1500 California Place Names |
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Sommario/riassunto |
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This is the new "pocket" version of the classic California Place Names, first published by California in 1949. Erwin G. Gudde's monumental work, which went through several editions during its author's lifetime, has now been released in an expanded and updated edition by William Bright. The abridged version, originally called 1000 California Place Names, has grown to a dynamic 1500 California Place Names in Bright's hands. Those who have used and enjoyed 1000 California Place Names through the decades will be glad to know that 1500 California Place Names is not only bigger but better. This handbook focuses on two sorts of names: those that are well-known as destinations or geographical features of the state, such as La Jolla, Tahoe, and Alcatraz, and those that demand attention because of their problematic origins, whether Spanish like Bodega and Chamisal or Native American like Aguanga and Siskiyou.Names of the major Indian tribes of California are included, since some of them have been directly adapted as place names and others have been the source of a variety of names. |
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Bright incorporates his own recent research and that of other linguists and local historians, giving us a much deeper appreciation of the tangled ancestry many California names embody. Featuring phonetic pronunciations for all the Golden State's tongue-twisting names, this is in effect a brand new book, indispensable to California residents and visitors alike. |
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2. |
Record Nr. |
UNINA9910139509603321 |
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Titolo |
Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen |
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Pubbl/distr/stampa |
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Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 |
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ISBN |
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1-282-68958-4 |
9786612689581 |
0-470-68626-X |
0-470-68670-7 |
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Descrizione fisica |
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1 online resource (505 p.) |
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Altri autori (Persone) |
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KrishnanKannan <1961-> |
AndersenMelvin E |
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Disciplina |
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Soggetti |
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Toxicology - Mathematical models |
Biological models |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Quantitative Modeling in Toxicology; Contents; Preface; About the Editors; About the Book; List of Contributors; SECTION 1 INTRODUCTION; 1 Quantitative Modeling in Toxicology: An Introduction; SECTION 2 PHYSIOLOGICALLY-BASED TOXICOKINETIC AND PHARMACOKINETIC (PBPK) MODELING; 2 PBPK Modeling: A Primer; 3 Pharmacokinetic Modeling of Manganese - An Essential Element; 4 Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures; 5 Physiological Parameters and Databases for PBPK Modeling; SECTION 3 MODELING TOXICANT-TARGET INTERACTIONS; 6 |
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Modeling Cholinesterase Inhibition |
7 Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration8 Bistable Signaling Motifs and Cell Fate Decisions; 9 Ultrasensitive Response Motifs in Biochemical Networks; 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; 11 Modeling Liver and Kidney Cytotoxicity; SECTION 4 MODELING TISSUE AND ORGANISM RESPONSES; 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; 13 Two-Stage Clonal Growth Modeling of Cancer; 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures |
15 (Q)SAR Models of Adverse Responses: Acute Systemic ToxicitySECTION 5 MODEL APPLICATION AND EVALUATION; 16 Modeling Exposures to Chemicals From Multiple Sources and Routes; 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; 18 Quantitative Modeling in Noncancer Risk Assessment; 19 Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment; 20 Uncertainty, Variability, and Sensitivity Analyses in Simulation Models; 21 Evaluation of Quantitative Models in Toxicology: Progress and Challenges; Index |
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Sommario/riassunto |
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Governments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter desc |
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