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Record Nr. |
UNINA9910456170603321 |
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Titolo |
Standing operating procedures for developing acute exposure guideline levels for hazardous chemicals [[electronic resource] /] / Subcommittee on Acute Exposure Guideline Levels ...[et al.] |
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Pubbl/distr/stampa |
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Washington ; ; [England], : National Academy Press, c2001 |
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ISBN |
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1-280-18464-7 |
9786610184644 |
0-309-57011-5 |
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Descrizione fisica |
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1 online resource (224 p.) |
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Disciplina |
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Soggetti |
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Hazardous substances - Risk assessment - United States |
Chemicals - Physiological effect |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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""Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals""; ""Copyright""; ""Preface""; ""Contents""; ""Introduction""; ""REVIEW OF THE NAC DOCUMENT""; ""REFERENCES""; ""Roster National Advisory Committee for Acute Exposure Guideline Levels (NAC/AEGL Committee) for Hazardous Substances""; ""COMMITTEE MEMBERS""; ""Past Committee Members""; ""Participants from Cooperative Partner Countries""; ""Other Participants""; ""Oak Ridge National Laboratory Staff""; ""AEGL Program Senior Staff""; ""Appendix""; ""Preface"" |
""1. Overview of AEGL Program and NAC/AEGL Committee""""HISTORY""; ""PURPOSE AND OBJECTIVES OF THE AEGL PROGRAM AND THE NAC/AEGL COMMITTEE""; ""COMMITTEE MEMBERSHIP AND ORGANIZATIONAL STRUCTURE""; ""SELECTION OF CHEMICALS FOR AEGL DEVELOPMENT""; ""SCIENTIFIC CREDIBILITY OF AEGL VALUES""; ""THE AEGL DEVELOPMENT AND PEER-REVIEW PROCESS""; ""Stage 1: Draft AEGLs""; ""Stage 2: Proposed AEGLs""; ""Stage 3: Interim AEGLs""; ""Stage 4: Final AEGLs""; ""OPERATION OF THE NAC/AEGL COMMITTEE""; ""VALUE OF A COLLABORATIVE EFFORT IN THE AEGL PROGRAM""; |
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""APPLICATIONS OF THE AEGL VALUES"" |
""2. Derivation of AEGL Values""""2.1 CHARACTERIZATION OF AEGLS""; ""2.2 EMPIRICAL TOXICOLOGIC ENDPOINTS AND METHODS FOR DETERMINING EXPOSURE CONCENTRATIONS USED TO DERIVE AEGLS 1, 2, AND 3""; ""2.2.1 Selection of the Highest Exposure Level at Which the Effects That Define an AEGL Are Not Observed""; ""2.2.2 Selection of Health-Effect Endpoints for AEGL-1, AEGL-2, and AEGL-3""; ""2.2.2.1 AEGL-1 Endpoints""; ""2.2.2.1.1 No Value Established�AEGL-1 Is Close to or Exceeds AEGL-2""; ""2.2.2.1.2 No Value Established�Insufficient Data"" |
""2.2.2.1.3 Highest Experimental Exposure Without an AEGL-1 Effect""""2.2.2.1.4 Effect Level for a Response""; ""2.2.2.2 AEGL-2 Endpoints""; ""2.2.2.2.1 Highest Experimental Exposure Without an AEGL-2 Effect""; ""2.2.2.2.2 Effect Level for a Toxic Response That Was Not Incapacitating or Not Irreversible""; ""2.2.2.2.3 A Fraction of the AEGL-3 Value""; ""2.2.2.3 AEGL-3 Endpoints""; ""2.2.2.3.1 Highest Exposure Level That Does Not Cause Lethality�Experimentally Observed Threshold (AEGL-3 NOAEL)"" |
""2.2.2.3.2 Highest Exposure Level That Does Not Cause Lethality�Estimated Lethality Threshold�One-Third of the LC50""""2.2.2.3.3 Highest Exposure Level That Does Not Cause Lethality�Benchmark Exposure Calculation of the 5% and 1% Response""; ""2.2.2.3.4 Effect Level for a Response""; ""2.3 GUIDELINES AND CRITERIA FOR THE SEARCH STRATEGY, EVALUATION, SELECTION, AND DOCUMENTATION OF KEY DATA AND SUPPORTING�""; ""2.3.1 Search Strategy""; ""2.3.2 Evaluation, Selection, and Documentation of Key and Supporting Data""; ""2.3.3 Elements for Discussion on Data Adequacy and Research Needs"" |
""2.4 DOSIMETRY CORRECTIONS FROM ANIMAL TO HUMAN EXPOSURES"" |
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