Pharmacokinetics in risk assessment [[electronic resource] /] / Subcommittee on Disinfectants and Disinfectant By-Products, Safe Drinking Water Committee, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences, National Research Council

• Record Nr.: UNINA9910455447303321
• Pubbl/distr/stampa: Washington, D.C., : National Academy Press, 1987
• ISBN: 1-280-22160-7; 9786610221608; 0-309-55769-0; 0-585-15539-9
• Descrizione fisica: 1 online resource (512 p.)
• Collana: Drinking water and health ; ; v.8
• Disciplina: 333.9122
• Soggetti: Drinking water - Contamination - United States; Drinking water - Contamination; Drinking water - Health aspects - United States; Drinking water - Health aspects; Water - Pollution - Toxicology; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di contenuto: ""Pharmacokinetics in Risk Assessment""; ""Copyright""; ""PREFACE""; ""Contents""; ""PART I INTRODUCTION: THE PROBLEM AND AN APPROACH ""; ""Risk Assessment: Historical Perspectives""; ""References""; ""Tissue Dosimetry in Risk Assessment, or What's the Problem Here Anyway?""; ""INTRODUCTION""; ""A DOSE OF WHAT?""; ""ISN'T THIS VOLUME ABOUT PHARMACOKINETICS?""; ""GENOTOXIC CARCINOGENS""; ""PARENT CHEMICAL""; ""STABLE METABOLITES""; ""REACTIVE, NONISOLATABLE METABOLITES""; ""INTERCALATING AGENTS""; ""EPIGENETIC CARCINOGENS""; ""SUMMARY""; ""References""; ""PART II MATHEMATICAL MODELING ""; ""Modeling: An Introduction""""References""; ""Physiologically Based Pharmacokinetic Modeling""; ""INTRODUCTION""; ""BIOLOGICAL BASIS OF PHYSIOLOGICAL PHARMACOKINETICS""; ""DEVELOPMENT OF ; MODELS""; ""CHOICE OF COMPARTMENTS""; ""BASIC MASS BALANCES""; ""Mass Balance: Blood Pool""; ""Mass Balance: Tissue Region i""; ""SIMPLIFICATIONS OF MASS BALANCES""; ""Examples""; ""DISCUSSION""; ""FUTURE RESEARCH NEEDS""; ""References""; ""PART III GENERALIZATIONS AND EXTRAPOLATIONS ""; ""Allometry: Body Size Constraints in Animal Design""; ""INTRODUCTION""; ""SIZE, DESIGN, AND PHARMACOKINETICS""; ""Aerobic Energetics of Muscle In Vivo""""Conflict of Physiological and Chronological Time""; ""Species Extrapolations, Physiological Time, and Pharmacokinetics""; ""CONCLUSIONS""; ""SUMMARY""; ""References""; ""Prediction of In Vivo Parameters of Drug Metabolism and Distribution from In Vitro Studies""; ""IN VITRO PREDICTION OF IN VIVO DRUG METABOLISM""; ""IN VITRO PREDICTION OF IN VIVO DRUG BINDING AND DISTRIBUTION""; ""CONCLUSION""; ""References""; ""Dose, Species, and Route Extrapolation: General Aspects""; ""DIFFERENT PROBLEMS AND OBJECTIVES, DIFFERENT MODELS""; ""Different Mechanisms""; ""GENERAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS""""Simplification of Models""; ""Rates of Formation of Complexes""; ""Diffusional Barriers and Modified Fick's Law""; ""Simple PB-PK Models""; ""Basic Parameters fu and R""; ""Nonlinear Kinetics and Lost Concepts""; ""INTERFACE BETWEEN PB-PK MODELS AND CLEARANCES""; ""Organ Availabilities (F), Extraction Ratios (E), and Clearances (CL)""; ""Physiologically Based Linear Compartmental Pharmacokinetic Models""; ""Validity of the Assumption of Virtual Steady State""; ""Calculation of Other Compartmental Model Parameters""; ""Approximations of Terminal Half-Lives""""Approximate Time Required to Approach Steady State""; ""LINEAR PHARMACOKINETIC SYSTEMS""; ""Total Body Clearance""; ""Importance of the Unbound Concentration of Substances""; ""Classification of Organs; Routes of Administration""; ""Non-First-Pass, Nonelimination Organs""; ""Range of Maximum and Minimum Unbound Concentrations in Nonelimination Organs and Repetitive Administration""; ""Non-First-Pass, Elimination Organs""; ""FIRST-PASS, NONELIMINATION ORGANS""; ""First-Pass, Elimination Organs""; ""ROUTE-TO-ROUTE EXTRAPOLATION""; ""Lungs and Skin Administration""

Fine & dandy : the life and work of Kay Swift / / Vicki Ohl

• Record Nr.: UNINA9910971248903321
• Autore: Ohl Vicki <1950->
• Pubbl/distr/stampa: New Haven, : Yale University Press, c2004
• ISBN: 1-281-73059-9; 9786611730598; 0-300-13039-2
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (329 p.)
• Disciplina: 780/.92; B
• Soggetti: Composers - United States; Women composers - United States
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes list of works (p. 243-250), bibliographical references (p. 279-284), and index.
• Nota di contenuto: Prelude -- Professional and personal choices -- Highbrow/lowbrow in New York City -- Fine and dandy -- Stagestruck : the ballet to Radio City -- Gershwin obsession -- New frontiers -- She'll have Manhattan -- Challenges -- The show won't fold in Philadelphia -- Keep on keepin' on -- Finale.
• Sommario/riassunto: Kay Swift (1897-1993) was one of the few women composers active on Broadway in the first half of the twentieth century. Best known as George Gershwin's assistant, musical adviser, and intimate friend, Swift was in fact an accomplished musician herself, a pianist and composer whose Fine and Dandy (1930) was the first complete Broadway musical written by a woman. This fascinating book-the first biography of Swift-discusses her music and her extraordinary life.Vicki Ohl describes Swift's work for musical theater, the ballet, Radio City Music Hall's Rockettes, and commercial shows. She also tells how Swift served as director of light music for the 1939 World's Fair, eloped with a cowboy from the rodeo at the fair, and abandoned her native New York for Oregon, later fashioning her experiences into an autobiographical novel, Who Could Ask for Anything More? Informed by rich material, including Swift's unpublished memoirs and extensive interviews with ; her family members and friends, this book captures the essence and spirit of a remarkable woman.