Blue dreams [[electronic resource] ] : Korean Americans and the Los Angeles riots / / Nancy Abelmann and John Lie

• Record Nr.: UNINA9910455180203321
• Autore: Abelmann Nancy
• Pubbl/distr/stampa: Cambridge, Mass., : Harvard University Press, 1995
• ISBN: 0-674-02003-0
• Descrizione fisica: 1 online resource (288 p.)
• Altri autori (Persone): LieJohn
• Disciplina: 979.4/94004957
• Soggetti: Korean Americans - California - Los Angeles - History - 20th century; Riots - California - Los Angeles - History - 20th century; Electronic books.; Los Angeles (Calif.) Ethnic relations
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references (p. [225]-265) and index.
• Nota di contenuto: Contents ; Preface ; 1. The Los Angeles Riots, the Korean American Story ; 2. Reckoning via the Riots ; 3. Diaspora Formation: Modernity and Mobility ; 4. Mapping the Korean Diaspora in Los Angeles ; 5. Korean American Entrepreneurship ; 6. American Ideologies on Trial ; Conclusion ; Notes ; References ; Index
• Sommario/riassunto: No one will soon forget the image, blazed across the airwaves, of armed Korean Americans taking to the rooftops as their businesses went up in flames during the Los Angeles riots. Why Korean Americans? What stoked the wrath the riots unleashed against them? Blue Dreams is the first book to make sense of these questions, to show how Korean Americans, variously depicted as immigrant seekers after the American dream or as racist merchants exploiting African Americans, emerged at the crossroads of conflicting social reflections in the aftermath of the 1992 riots. The situation of Los Angeles's Korean Americans touches on some of the most vexing issues facing American society today: ethnic conflict, urban poverty, immigration, multiculturalism, and ideological polarization. Combining interviews and deft socio-historical analysis, Blue Dreams gives these problems a human face and at the same time clarifies the historical, political, and economic factors that render them so complex. In the lives and voices of Korean Americans, ; the authors locate a profound challenge to cherished assumptions about the United States and its minorities. Why did Koreans come to the United States? Why did they set up shop in poor inner-city neighborhoods? Are they in conflict with African Americans? These are among the many difficult questions the authors answer as they probe the transnational roots and diversity of Los Angeles's Korean Americans. Their work finally shows us in sharp relief and moving detail a community that, despite the blinding media focus brought to bear during the riots, has nonetheless remained largely silent and effectively invisible. An important corrective to the formulaic accounts that have pitted Korean Americans against African Americans, Blue Dreams places the Korean American story squarely at the center of national debates over race, class, culture, and community.Table of Contents: Preface The Los Angeles Riots, the Korean American Story Reckoning via the Riots Diaspora Formation: Modernity and Mobility Mapping the Korean Diaspora in Los Angeles Korean American Entrepreneurship American Ideologies on Trial Conclusion Notes References IndexReviews of this book: Blue Dreams--a poetic allusion to the clear blue sky that Koreans see as a symbol of freedom--is a welcome exploration by outsiders into the vexing and largely invisible Korean-American predicament in Los Angeles and the nation. [Abelmann and Lie 's] colorful interview subjects offer sharp observations.--K.W. Lee, Los Angeles TimesReviews of this book: An informed and thoughtful examination of Korean immigration to the United States since 1970.[Abelmann and Lie] show that even in a period as short as twenty-five years, there have been successive waves of differently motivated, differently resourced Korean immigrants, and their experiences and reactions have differed accordingly.--Michael Tonry, Times Literary SupplementReviews of this book: [The authors'] transnational perspective is particularly effective for explicating Korean immigrants' behaviors, activities, and feelings.Interesting and readable.--Pyong Gap Min, American Journal of SociologyReviews of this book: Beginning with a poetic book title, the authors recount in depth as to how the 'Blue Dreams' of the Korean-American merchants in East Los Angeles had shattered in the midst of [the] 1992 riot that turned out to be 'elusive dreams' in America.The book not only portrays the L.A. riot surrounding the Korean merchants, but also characterizes diaspora of the Koreans in America. The authors have also examined with scholarly insights the more complex socioeconomic and political underplay the Koreans encountered in their 'Promised New Land'.--Eugene C. Kim, International Migration Review

High-throughput screening in drug discovery [[e-book] /] / edited by Jörg Hüser

• Record Nr.: UNINA9910830771703321
• Pubbl/distr/stampa: Weinheim, : Wiley-VCH; [Chichester, : John Wiley, distributor], c2006
• ISBN: 1-280-72366-1; 9786610723669; 3-527-60932-6; 3-527-60936-9
• Descrizione fisica: 1 online resource (371 p.)
• Collana: Methods and principles in medicinal chemistry ; ; v. 35
• Classificazione: 44.38
• Altri autori (Persone): HüserJörg
• Disciplina: 615.19; 615.1900285
• Soggetti: High throughput screening (Drug development); Pharmaceutical chemistry
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: High-Throughput Screening in Drug Discovery; Foreword; List of Contents; Preface; List of Contributors; Part I Concept of Screening; 1 Chemical Genetics: Use of High-throughput Screening to Identify Small-molecule Modulators of Proteins Involved in Cellular Pathways with the Aim of Uncovering Protein Function; 1.1 Introduction; 1.2 Classical and Chemical Genetics; 1.2.1 Forward and Reverse Screens; 1.3 Identifying Bioactive Molecules; 1.4 Target Identification; 1.4.1 Hypothesis-driven Target Identification; 1.4.2 Affinity-based Target Identification; 1.4.3 Genomic Methods of Target Identification1.4.4 Proteomic Methods; 1.5 Discovery for Basic Research Versus Pharmacotherapy Goals; 1.6 Chemical Genetic Screens in the Academic Setting; 1.7 Conclusions; 2 High-throughput Screening for Targeted Lead Discovery; 2.1 Chemical Libraries for High-throughput Screening; 2.2 Properties of Lead Structures; 2.3 Challenges to High-throughput Screening; 2.4 Assay Technologies for High-throughput Screening; 2.5 Laboratory Automation; 2.6 From Target Selection to Confirmed Hits - ; the HTS Workflow and its Vocabulary; 2.7 Separating Specific Modulators from Off-Target Effects2.8 Data Analysis and Screening Results; 2.9 Conclusions; Part II Automation Technologies; 3 Tools and Technologies that Facilitate Automated Screening; 3.1 Introduction - the Necessity to Automate; 3.1.1 Compound Libraries; 3.1.2 Targets and Data Points; 3.1.3 Main Issues Facing HTS Groups Today; 3.1.4 Benefits of Miniaturization; 3.1.5 Benefits of Automated HTS; 3.1.6 Screening Strategies; 3.1.7 Ultra HTS (UHTS); 3.2 Sample Carriers; 3.2.1 A Brief History of the Microplate; 3.2.2 Microplate Usage Today; 3.2.3 Microplate Arrays; 3.2.4 Non-microplate Alternatives3.2.4.1 Labchips; 3.2.4.2 LabCDs; 3.2.4.3 LabBrick; 3.2.4.4 Arrayed Compound Screening; 3.3 Liquid Handling Tools; 3.3.1 Main Microplate Dispense Mechanisms; 3.3.1.1 Pin Tools; 3.3.1.2 Air and Positive Displacement; 3.3.1.3 Peristaltic; 3.3.1.4 Solenoid-syringe; 3.3.1.5 Solenoid-pressure bottle; 3.3.1.6 Capillary Sipper; 3.3.1.7 Piezoelectric; 3.3.1.8 Acoustic Transducer; 3.3.2 HTS Liquid Handling Applications and Dispensing Technologies Used; 3.3.2.1 Bulk Reagent and Cell Addition; 3.3.2.2 Compound Reformatting and Nanoliter Dispensing; 3.3.2.3 Cherry Picking and Serial Dilution3.3.2.4 Microplate Washing; 3.4 Detection Technologies; 3.4.1 Main Detection Modalities Used in HTS; 3.4.2 Plate Readers; 3.4.3 Plate Imagers; 3.4.3.1 Macro-imaging; 3.4.3.2 Micro-imaging; 3.4.4 Dispense and Read Devices; 3.4.5 Other Detection Technologies; 3.4.6 Automation of Detection Technologies; 3.4.7 Potential Sources of Reading Error; 3.5 Laboratory Robotics; 3.5.1 Traditional Workstations; 3.5.2 Robotic Sample Processors; 3.5.3 Plate Storage Devices; 3.5.4 Plate Moving Devices; 3.5.5 Fully Integrated Robotic Systems; 3.5.6 Turnkey Workstations; 3.5.7 Automated Cell Culture Systems
• Sommario/riassunto: Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results.For both academics and professionals in the pharma and biotech industries working on small molecule screening.