Modern methods of clinical investigation [[electronic resource] /] / Annetine C. Gelijns, editor ; Committee on Technological Innovation in Medicine, Institute of Medicine

• Record Nr.: UNINA9910455143003321
• Pubbl/distr/stampa: Washington, D.C., : National Academy Press, 1990
• ISBN: 1-280-21225-X; 9786610212255; 0-309-54356-8; 0-585-12524-4
• Descrizione fisica: 1 online resource (244 p.)
• Collana: Medical innovation at the crossroads ; ; v. 1
• Altri autori (Persone): GelijnsAnnetine
• Disciplina: 610/.72
• Soggetti: Medical technology - Evaluation; Medical innovations - Evaluation; Medical care - Technological innovations; Meta-analysis; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Proceedings of a workshop held on May 3-4, 1989, supported by the Howard Hughes Medical Institute and the National Center for Health Services Research of the Department of Health and Human Services (grant 5 RO9 HS055 26 02).; Includes index.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: ""Modern Methods of Clinical Investigation""; ""Copyright""; ""Acknowledgments""; ""Preface""; ""Contents""; ""List of Abbreviations""; ""1 Medical Technology Development: An Introduction to the Innovation-Evaluation Nexus ""; ""PUTTING CLINICAL EVALUATION IN CONTEXT""; ""ISSUES IN INNOVATION AND EVALUATION: THE CASE OF STABLE ANGINA PECTORIS""; ""Beta-Blockers""; ""Coronary Artery Bypass Grafting""; ""PTCA Catheter Equipment""; ""Evaluative Shortcomings in Technology Development""; ""IMPROVING THE INNOVATION-EVALUATION NEXUS""; ""The Selection of Endpoints in Evaluative Research""; ""The Selection of Methods for Clinical Investigation""""Policy ; Mechanisms for Improving Developmental Decision Making""; ""REFERENCES""; ""2 The Selection of Endpoints in Evaluative Research ""; ""SURROGATE VERSUS CLINICAL ENDPOINTS""; ""CLINICAL ENDPOINTS""; ""SURROGATE ENDPOINTS""; ""REFERENCES""; ""3 Advances in Health Status Measurement: The Potential to Improve Experimental and Non-Experimental Data Collection""; ""THE CONDUCT OF CLINICAL TRIALS""; ""MEASUREMENT OF QUALITY OF LIFE AND OF HEALTH STATUS""; ""INCLUSION OF QUALITY OF LIFE AND HEALTH STATUS MEASURES IN CLINICAL TRIALS""; ""FOUR PROBLEMS REGARDING THE MEASUREMENT OF HEALTH STATUS IN CLINICAL TRIALS""""REFERENCES""; ""4 What Is Outcomes Research? ""; ""WHICH RATE IS RIGHT?""; ""ENGAGING PATIENTS IN THE DECISION PROCESS""; ""EXTENDING ASSESSMENT TO ALL RELEVANT TREATMENT THEORIES""; ""THE EVALUATIVE CLINICAL SCIENCES AND THE FUTURE OF MEDICINE""; ""REFERENCES""; ""5 Strengths and Weaknesses of Health Insurance Data Systems for Assessing Outcomes""; ""STRENGTHS""; ""System-Wide, Population-Based Data""; ""Efficacy versus Effectiveness""; ""Large Numbers and Time Series""; ""Events Unaffected by Recall""; ""Unobtrusive Nature""""Multiple Comparisons""; ""Design Flexibility""; ""Potential for Multiple Projects""; ""Focus on Risks""; ""Clinical Decision Making""; ""WEAKNESSES""; ""Structural Limitations""; ""Bias Due to Reporting and Coding""; ""Bias Due to Differential Contact""; ""Benefits of Treatment""; ""CONTROVERSIAL AREAS""; ""Risk Adjustment""; ""Outcome Measures""; ""EXPANDING DATA BASES""; ""Record Linkage""; ""Primary Data Collection""; ""DISCUSSION""; ""REFERENCES""; ""6 Prescription-Event Monitoring: An Example of Total Population Post-Marketing Drug Surveillance ""; """"THE NUMBERS GAME""""""VOLUNTARY REPORTING SYSTEMS""; ""POST-MARKETING SURVEILLANCE""; ""PRESCRIPTION-EVENT MONITORING""; ""COMPARATIVE STUDIES OF NSAIDS""; ""POST-MARKETING SURVEILLANCE AND POST-MARKETING CLINICAL TRIALS""; ""CONCLUSION""; ""REFERENCES""; ""7 The Role of Decision Analysis in the Translation of Research Findings into Clinical Practice ""; ""DECISION ANALYSIS AT THE INTERFACE BETWEEN CLINICAL INVESTIGATION AND CLINICAL PRACTICE""; ""WHAT DECISION ANALYSIS IS""; ""THE LIMITATIONS OF DECISION ANALYSIS: WHAT IT IS NOT""; ""SETTING PRIORITIES AND PARAMETERS FOR CLINICAL INVESTIGATION""