1.

Record Nr.

UNINA9910454265103321

Titolo

The activities of bacterial pathogens in vivo [[electronic resource] ] : based on contributions to a Royal Society discussion meeting : London, UK : meeting held on 20-21 October 1999 / / editors, H. Smith ... [et al.]

Pubbl/distr/stampa

London, : Imperial College Press, 2001, c2000

ISBN

1-281-86607-5

9786611866075

1-84816-161-1

Descrizione fisica

1 online resource (410 p.)

Altri autori (Persone)

SmithHarry <1921-2011.>

Disciplina

579.3

Soggetti

Virulence (Microbiology)

Bacterial diseases

Pathogenic bacteria

Host-bacteria relationships - Research - Methodology

Molecular microbiology

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Originally published in: Philosophical transactions of the Royal Society series B. 2000.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

CONTENTS               ; Preface              ; Introduction                   ; Questions about the Behaviour of Bacterial Pathogens in Vivo                                                                   ; DNA Topology and Adaptation of Salmonella typhimurium to an Intracellular Environment                                                                                            ; New Methods for Studying Bacterial Behaviour in Vivo

The Pathogenesis of Shigella flexneri Infection: Lessons from in Vitro and in Vivo Studies                                                                                                 Detection and Analysis of Gene Expression During Infection by in Vivo Expression Technology                                                                                                  ; Measurement of Bacterial Gene Expression in Vivo

Identification and Analysis of Bacterial Virulence Genes in Vivo                                                                       Salmonella Interactions with Host Cells: In Vitro to in Vivo                                                                   ; Impact of the New Methods                                ; In Vivo Gene



Expression and the Adaptive Response: From Pathogenesis to Vaccines and Antimicrobials

Challenge of Investigating Biologically Relevant Functions of Virulence Factors in Bacterial Pathogens                                                                                                             Virulence Gene Regulation Inside and Outside                                                   ; Evidence for Operation in Vivo of Aspects of Pathogenicity Revealed by Recent Work in Vitro: Potential Use of New Methods

Quorum Sensing and the Population-dependent Control of Virulence                                                                       Type III Secretion: A Bacterial Device for Close Combat with Cells of Their Eukaryotic Host                                                                                                  ; Evolution of Microbial Pathogens                                       ; The Immune Responses to Bacterial Antigens Encountered in Vivo at Mucosal Surfaces                                                                                         ; Index

Sommario/riassunto

Pathogenic bacteria have unique biological properties, which enable them to invade a host and cause sickness. The molecular bases of these biological properties are the determinants of pathogenicity, and the research objectives are to recognize them, identify them chemically and relate their structure to function. Most of our present knowledge comes from studies with cultures <i>in vitro</i>. However, there is a rising interest in bacterial behaviour in the infected host and new methods have been developed for studying it. This book describes those methods and shows how they, and a recent sur