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Record Nr. |
UNINA9910454078003321 |
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Titolo |
Metal ions and neurodegenerative disorders [[electronic resource] /] / editor, Paolo Zatta |
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Pubbl/distr/stampa |
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New Jersey, : World Scientific, c2003 |
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ISBN |
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1-281-95608-2 |
9786611956080 |
981-279-669-X |
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Descrizione fisica |
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1 online resource (538 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Metal ions - Physiological effect |
Molecular neurobiology |
Nervous system - Degeneration |
Neurotoxicology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents ; Preface ; List of Contributors ; Chapter 1. Metal-Catalyzed Redox Activity in Neurodegenerative Disease ; 1. INTRODUCTION ; 1.1. Redox-Active Transition Metals in AD ; 1.2. Aggregation of Amyloid-B and Amyloid B Protein Precursor/Amyloid-p-Linked ROS Production |
1.3. Iron in Neurodegenerative Disease 1.4. Iron-Mediated Oxidative Stress in Parkinson's Disease ; 1.5. Manganese and Parkinson's Disease ; 1.6. Antioxidant and Transition Metal Homeostasis ; 1.7. CuZnSOD Mutations and Familial Amyotrophic Lateral Sclerosis ; 2. CONCLUSIONS |
Chapter 2. Metals Distribution and Regionalization in the Brain 1. TRACE ELEMENT DISTRIBUTION IN NORMAL HUMAN BRAIN ; 1.1. Aluminum Iron Copper and Zinc Distribution in Normal Human Brain Sites in Relation to Age ; 1.2. Aluminum ; 1.3. Iron ; 1.4. Copper |
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; 1.5. Zinc |
2. TRACE ELEMENT IMBALANCES IN NEURODEGENERATIVE DISEASES 2.1. Aluminum Iron Copper and Zinc in Alzheimer's Disease ; 2.2. Factors Affecting the Final Results ; 2.3. Aluminum Iron Copper and Zinc in Parkinson's Disease |
2.4. Aluminum Iron Copper and Zinc in Western Pacific Parkinsonism-Dementia 2.5. Aluminum Iron Copper and Zinc in Amyotrophic Lateral Sclerosis ; 3. FINAL REMARKS ; Chapter 3. The Olfactory Pathway as a Route of Entry of Metals into the Brain ; 1. INTRODUCTION |
2. ANATOMY OF THE OLFACTORY SYSTEM |
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Sommario/riassunto |
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Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences |
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2. |
Record Nr. |
UNINA9910777025303321 |
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Autore |
Chudleigh Mary Lee, Lady, <1656-1710.> |
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Titolo |
The Poems and Prose of Mary, Lady Chudleigh [[electronic resource]] |
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Pubbl/distr/stampa |
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Oxford, : Oxford University Press, USA, 1993 |
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ISBN |
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0-19-772563-5 |
0-19-535933-X |
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Descrizione fisica |
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1 online resource (429 p.) |
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Collana |
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Women Writers in English 1350-1850 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Women |
Women and literature |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Contents; Foreword; Introduction; The Ladies Defence: Or, The Bride-Woman's Counsellor Answer'd; Poems on Several Occasions; The Song of the Three Children Paraphras'd; Essays upon Several Subjects in Prose and Verse; Index of First Lines of Poems |
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Sommario/riassunto |
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The first edition of the collected poetry and prose of the Restoration feminist, Mary, Lady Chudleigh (1656-1710), this volume includes The Ladies Defence as well as her final prose meditations. New biographical and bibliographical information in the Introduction revises the existing accounts of her life and literary career. The volume makes available for the first time the complete range of Chudleigh's literary experiments and calls for a reassessment of the image of the woman writer of the Restoration. A friend of John Dryden and Mary Astell, Chudleigh experimented with a variety of literary |
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