1.

Record Nr.

UNINA9910454078003321

Titolo

Metal ions and neurodegenerative disorders [[electronic resource] /] / editor, Paolo Zatta

Pubbl/distr/stampa

New Jersey, : World Scientific, c2003

ISBN

1-281-95608-2

9786611956080

981-279-669-X

Descrizione fisica

1 online resource (538 p.)

Altri autori (Persone)

ZattaPaolo

Disciplina

616.80471

Soggetti

Metal ions - Physiological effect

Molecular neurobiology

Nervous system - Degeneration

Neurotoxicology

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Contents               ; Preface              ; List of Contributors                           ; Chapter 1. Metal-Catalyzed Redox Activity in Neurodegenerative Disease                                                                             ; 1. INTRODUCTION                      ; 1.1. Redox-Active Transition Metals in AD                                                ; 1.2. Aggregation of Amyloid-B and Amyloid B Protein Precursor/Amyloid-p-Linked ROS Production

1.3. Iron in Neurodegenerative Disease                                             1.4. Iron-Mediated Oxidative Stress in Parkinson's Disease                                                                 ; 1.5. Manganese and Parkinson's Disease                                             ; 1.6. Antioxidant and Transition Metal Homeostasis                                                        ; 1.7. CuZnSOD Mutations and Familial Amyotrophic Lateral Sclerosis                                                                        ; 2. CONCLUSIONS

Chapter 2. Metals Distribution and Regionalization in the Brain                                                                      1. TRACE ELEMENT DISTRIBUTION IN NORMAL HUMAN BRAIN                                                          ; 1.1. Aluminum Iron Copper and Zinc Distribution in Normal Human Brain Sites in Relation to Age                                                                                                     ; 1.2. Aluminum                    ; 1.3. Iron                ; 1.4. Copper                  


; 1.5. Zinc

2. TRACE ELEMENT IMBALANCES IN NEURODEGENERATIVE DISEASES                                                                2.1. Aluminum Iron Copper and Zinc in Alzheimer's Disease                                                                ; 2.2. Factors Affecting the Final Results                                               ; 2.3. Aluminum Iron Copper and Zinc in Parkinson's Disease

2.4. Aluminum Iron Copper and Zinc in Western Pacific Parkinsonism-Dementia                                                                                  2.5. Aluminum Iron Copper and Zinc in Amyotrophic Lateral Sclerosis                                                                          ; 3. FINAL REMARKS                       ; Chapter 3. The Olfactory Pathway as a Route of Entry of Metals into the Brain                                                                                    ; 1. INTRODUCTION

2. ANATOMY OF THE OLFACTORY SYSTEM

Sommario/riassunto

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.  Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences