1.

Record Nr.

UNINA9910454034503321

Titolo

Towards drugs of the future [[electronic resource] ] : key issues in lead finding and lead optimization / / edited by C.G. Kruse and H. Timmerman

Pubbl/distr/stampa

Amsterdam, : IOS Press, 2008

ISBN

6612070617

1-282-07061-4

9786612070617

1-4416-0553-3

600-00-1261-6

1-60750-391-3

Descrizione fisica

1 online resource (140 p.)

Collana

Solvay Pharmaceuticals Conferences, , 1566-7685 ; ; v. 9

Altri autori (Persone)

KruseC. G <1952-> (Chris G.)

TimmermanH (Hendrick)

Disciplina

615.1072

Soggetti

Pharmaceutical chemistry

Drug development

Pharmaceutical industry

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Title page; Preface; List of Contributors; Contents; Conference Preface and Keynote Lecture; A Thermodynamic Platform for Drug Discovery and Optimization; Structure-Based Design: Past, Present, and Future; Sense and Nonsense in Drug Discovery: A Chemical Perspective; Synthesis at the Interface of Chemistry and Biology: How and Why?; Drug Design with ADME in Mind: Recent Paradigm Shifts in Drug Discovery; Hypothesis Generation for Scientific Discovery. Examples from the Use of KEMĀ®, a Rule-Based Method for Multi-Objective Analysis and Optimization

Does Size Matter? Facts and Thoughts on Recombinant DrugsCan Nanotechnology Improve the Oral Delivery of Therapeutic Proteins?; The Omeprazole Story: How Endurance in Research May Pay Off;



Conceptual Design of Cannabinoid CB1 Receptor Antagonists; Author Index

Sommario/riassunto

The number of novel medications in the global industry pipeline is insufficient to suffice demand of the markets, the financial performance of several companies is declining, and sales and marketing costs are rising. This title addresses the development in synthetic and medicinal chemistry with the emphasis on global challenges.