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1. |
Record Nr. |
UNINA9910453537603321 |
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Titolo |
Mammalian cell biotechnology in protein production [[electronic resource] /] / editors, Hansjörg Hauser, Roland Wagner |
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Pubbl/distr/stampa |
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Berlin ; ; New York, : Walter de Gruyter, 1997 |
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ISBN |
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Descrizione fisica |
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1 online resource (512 p.) |
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Classificazione |
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Altri autori (Persone) |
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HauserHansjörg <1949-> |
WagnerRoland <1956-> |
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Disciplina |
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Soggetti |
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Proteins - Biotechnology |
Animal cell biotechnology |
Mammals - Cytology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Frontmatter -- Preface -- Contents -- Contributors List -- 1. Genetic Manipulation of Mammalian Cells -- 1.1 Heterologous Expression of Genes in Mammalian Cells / Hauser, Hansjörg -- 1.2 Permanent Gene Expression in Mammalian Cells: Gene Transfer And Selection / Schlokat, Uwe / Himmelspach, Michèle / Falkner, Falko G. / Dorner, Friedrich -- 1.3 Vectors for Gene Transfer and Expression in Animal Cells / Sandig, Volker / Lieber, Andre / Strauss, Michael -- 1.4 Aspects of Gene Transfer and Gene Amplification in Recombinant Mammalian Cells / Wurm, Florian Μ. -- 1.5 Isolation of Recombinant Cell Clones Exhibiting High-Level Expression of the Introduced Gene / Wirth, Manfred -- 1.6 Genetic Engineering of Antibodies and Derivatives from Mammalian Cells / Schäffner, Michaela / Kaluza, Brigitte / Weidle, Ulrich Η. -- 1.7 Safety Evaluation of Products Derived From Mammalian Cell Lines / Onions, David -- 2. Biological Aspects of Animal Cells -- 2.1 Metabolic Control of Animal Cell Culture Processes / Wagner, Roland -- 2.2 Glycosylation: A Post-Translational Modification / Savage, Angela -- 3. Cell Cultivation Technology -- 3.1 Bioreactors Designed for Animal Cells / Tokashiki, Michiyuki / Yokoyama, Seiichi -- 3.2 Hydrodynamic Properties in Bioreactors / Chattopadhyay, Devamita |
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/ Garcia-Briones, Miguel / Venkat, Raghavan / Chalmers, Jeffrey J. -- 3.3 Kinetics and Simulation of Animal Cell Processes / Goergen, Jean-Louis / Marc, Annie / Engasser, Jean-Marc -- 3.4 On-line and Off-line Process Analysis / Scheper, Thomas / Freitag, Ruth / Scrienc, Friedrich -- 4. Down-Stream Processing -- 4.1 Principles of Product Extraction from Cell Culture and Purification for Pharmaceutical Proteins / Jungbauer, Alois -- 4.2 Validation of Downstream Processes / Walter, Joachim / Allgaier, Hermann -- Index -- Backmatter |
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Sommario/riassunto |
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"Hauser and Wagner have presented the new possibilities of Mammalian Cell Biology in a very informative and stimulating manner." Prof. Dr. Hans Fritz, Ludwig-Maximilians-University Munich |
"Hauser und Wagner haben die neuen Möglichkeiten der Mammalian Cell Biology sehr anregend dargestellt."Prof. Dr. Hans Fritz, Ludwig-Maximilians-Universität München |
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2. |
Record Nr. |
UNINA9910144096903321 |
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Autore |
Flower Darren R |
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Titolo |
Bioinformatics for vaccinology [[electronic resource] /] / Darren R. Flower |
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Pubbl/distr/stampa |
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Chichester, West Sussex, England ; ; Hoboken, NJ, : John Wiley & Sons, 2008 |
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ISBN |
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1-281-93944-7 |
9786611939441 |
0-470-69983-3 |
0-470-69982-5 |
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Edizione |
[1st edition] |
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Descrizione fisica |
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1 online resource (314 p.) |
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Disciplina |
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Soggetti |
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Immunoinformatics |
Vaccines - Design - Data processing |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Bioinformatics for Vaccinology; Contents; Preface; Acknowledgements; |
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Exordium; 1 Vaccines: Their place in history; Smallpox in history; Variolation; Variolation in history; Variolation comes to Britain; Lady Mary Wortley Montagu; Variolation and the Sublime Porte; The royal experiment; The boston connection; Variolation takes hold; The Suttonian method; Variolation in Europe; The coming of vaccination; Edward Jenner; Cowpox; Vaccination vindicated; Louis Pasteur; Vaccination becomes a science; Meister, Pasteur and rabies; A vaccine for every disease; In the time of cholera |
Haffkine and choleraBubonic plague; The changing face of disease; Almroth wright and typhoid; Tuberculosis, Koch, and Calmette; Vaccine BCG; Poliomyelitis; Salk and Sabin; Diphtheria; Whooping cough; Many diseases, many vaccines; Smallpox: Endgame; Further reading; 2 Vaccines: Need and opportunity; Eradication and reservoirs; The ongoing burden of disease; Lifespans; The evolving nature of disease; Economics, climate and disease; Three threats; Tuberculosis in the 21 st century; HIV and AIDS; Malaria: Then and now; Influenza; Bioterrorism; Vaccines as medicines |
Vaccines and the pharmaceutical industryMaking vaccines; The coming of the vaccine industry; 3 Vaccines: How they work; Challenging the immune system; The threat from bacteria: Robust, diverse, and endemic; Microbes, diversity and metagenomics; The intrinsic complexity of the bacterial threat; Microbes and humankind; The nature of vaccines; Types of vaccine; Carbohydrate vaccines; Epitopic vaccines; Vaccine delivery; Emerging immunovaccinology; The immune system; Innate immunity; Adaptive immunity; The microbiome and mucosal immunity; Cellular components of immunity; Cellular immunity |
The T cell repertoireEpitopes: The immunological quantum; The major histocompatibility complex; MHC nomenclature; Peptide binding by the MHC; The structure of the MHC; Antigen presentation; The proteasome; Transporter associated with antigen processing; Class II processing; Seek simplicity and then distrust it; Cross presentation; T cell receptor; T cell activation; Immunological synapse; Signal 1, signal 2, immunodominance; Humoral immunity; Further reading; 4 Vaccines: Data and databases; Making sense of data; Knowledge in a box; The science of -omes and -omics; The proteome |
Systems biologyThe immunome; Databases and databanks; The relational database; The XML database; The protein universe; Much data, many databases; What proteins do; What proteins are; The amino acid world; The chiral nature of amino acids; Naming the amino acids; The amino acid alphabet; Defining amino acid properties; Size, charge and hydrogen bonding; Hydrophobicity, lipophilicity and partitioning; Understanding partitioning; Charges, ionization, and pka; Many kinds of property; Mapping the world of sequences; Biological sequence databases; Nucleic acid sequence databases |
Protein sequence databases |
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Sommario/riassunto |
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"... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues-making the book enticing and useful, all at once..." Human Vaccines, 2010 ""... This book has sever |
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