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1. |
Record Nr. |
UNINA9910453498603321 |
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Autore |
Whiteman Kaye |
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Titolo |
Lagos : a cultural and historical imagination / / Kaye Whiteman |
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Pubbl/distr/stampa |
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Exeter, UK ; ; Charlottesville, Virginia : , : Andrews UK Limited, , 2013 |
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ISBN |
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1-908493-88-7 |
1-908493-89-5 |
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Descrizione fisica |
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1 online resource (320 p.) |
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Collana |
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Cities of the imagination |
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Disciplina |
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Soggetti |
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Culture |
Electronic books. |
Lagos (Nigeria) Description and travel |
Lagos (Nigeria) History |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Cover; Contents; Front Matter; Title Page; Publisher Information; Foreword by Femi Okunnu; A Personal Message from the CEO of BGL; Preface and Acknowledgements; Dedication; Introduction; Lagos; The Story of Lagos; The Topography of Lagos; Changing Society and the "Look" of the City; A True City of the Imagination; Music, Film, Art and the Havens in the Wilderness; Stories to Remember; The Long Shadow of FESTAC; Prominent Personalities of Lagos; Fela Anikulapo-Kuti; Streets of the Imagination; The Future City?; End Matter; Appendix; Further Reading; BGL and Lagos; Also Available |
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Sommario/riassunto |
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Lagos is one of the fastest growing cities in the world, expected in some projections to have a population of 25 million by 2025. This will make it the biggest metropolis in sub-Saharan Africa and possibly the world's third largest city. This phenomenal and continuing growth gives it a heady turbulence, especially as it only took on the form of a coherent urban entity in the eighteenth century. After Nigeria's independence Lagos remained both trading hub and, for thirty years, a federal capi... |
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2. |
Record Nr. |
UNINA9910464438403321 |
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Titolo |
Pathogenic Escherichia coli : molecular and cellular microbiology / / edited by Stefano Morabito |
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Pubbl/distr/stampa |
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Norfolk, England : , : Caister Academic Press, , [2014] |
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©2014 |
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ISBN |
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Descrizione fisica |
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1 online resource (316 p.) |
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Disciplina |
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Soggetti |
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Escherichia coli |
Microbiology |
Pathogenic microorganisms |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Contributors; Foreword; 1: Diarrhoeagenic Escherichia coli Infections in Humans; Introduction; Enteropathogenic E. coli (EPEC); Enterotoxigenic E. coli (ETEC); Enteroinvasive E. coli (EIEC); Enteroaggregative E. coli (EAggEC); Diffusely adherent E. coli (DAEC); Shiga toxin-producing E. coli (STEC) or verocytotoxin-producing E. coli (VTEC); 2: Pathogenic Escherichia coli in Domestic Mammals and Birds; Classification of pathogenic Escherichia coli; Diarrhoeagenic Escherichia coli; Enterotoxaemic Escherichia coli; Extraintestinal Escherichia coli; Concluding remarks |
3: Genomic Plasticity and the Emergence of New Pathogenic Escherichia coliIntroduction; Genome structure of extraintestinal and intestinal pathogenic E. coli; Mobile elements; Genome alterations during human infections - a model of real-time pathogen evolution; 4: Shiga Toxin-encoding Phages: Multifunctional Gene Ferries; General overview on Stx-phages; History and general description of Stx-phages; Diversity of Stx-phages; Genome structure of Stx-phages; Structure of the stx region; Stx-phage induction and its role in Stx production; Stx transduction and the emergence of new pathogens |
New pathogenic serotypes, outbreaks in Norway and GermanyThe |
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impact of multiple Stx-phages in the same genome; Stx2-phages in the environment, difficulties to evaluate the presence of lytic Stx2-phages; Biological impact of Stx-phages; Conclusions; 5: Shiga Toxins; Discovery of Shiga toxins; Genetic and environmental regulation of Shiga toxin production; Shiga toxin structure; Shiga toxin receptor(s); Toxin internalization and retrograde transport; Retro-translocation; Shiga toxin-induced apoptosis; Inhibition of protein synthesis and intoxication; Shiga toxin-induced cytokine synthesis |
Pathophysiology of organ damageIntervention strategies; Biomedical applications of Shiga toxins; Conclusions and future directions; 6: Escherichia coli Subtilase Cytotoxin: Structure, Function and Role in Disease; Introduction; Biological characterization; Cytotoxic mechanism; Receptor binding; Intracellular trafficking; Strain distribution of SubAB and identification of allelic variants; Pathological features and immune modulation; Role in disease; Conclusions; 7: Cell Cycle Modulating Toxins Produced by Escherichia coli; Cytotoxic necrotizing factor (CNF); Cytolethal distending toxins |
Cycle inhibiting factors (Cif)Colibactin; Conclusion; 8: The Heat-stable and Heat-labile Enterotoxins Produced by Enterotoxigenic Escherichia coli; Introduction; Heat-stable enterotoxin; Heat-labile enterotoxin; Conclusion; 9: Haemolysins; The HlyA protein; HlyA mechanism of action; HlyA role in virulence; Extracellular export of HlyA; Post-translational modification of HlyA; Genetics and regulation of hlyA expression; The EHEC haemolysin; The EHEC-Hly gene locus, its conservation and regulation; EHEC-Hly mechanism of action and role in pathogenesis; The ClyA (SheA, HlyE) protein |
Mechanism of action of ClyA |
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Sommario/riassunto |
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In recent years, a great deal of knowledge has accumulated on the features associated with the virulence of pathogenic E. coli. A large number of virulence genes have been identified and their products characterized. Great strides have been made in the understanding of the pathogenic mechanisms and the bacterium-host interaction. However, much remains elusive in the understanding of pathogenicity at a cellular and sub-cellular level. This is largely due to E. coli genome's plasticity: it generates great variability and facilitates the rapid emergence of new pathogenic variants. Elucidating the |
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