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1. |
Record Nr. |
UNINA9910144448403321 |
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Titolo |
Pathway analysis for drug discovery [[electronic resource] ] : computational infrastructure and applications / / edited by Anton Yuryev |
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Pubbl/distr/stampa |
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Hoboken, N.J., : John Wiley & Sons, c2008 |
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ISBN |
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1-281-83126-3 |
9786611831264 |
0-470-39927-9 |
0-470-39926-0 |
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Descrizione fisica |
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1 online resource (332 p.) |
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Collana |
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Wiley series on technologies for the pharmaceutical industry |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Drug development - Data processing |
DNA microarrays - Data processing |
Computational biology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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PATHWAY ANALYSIS FOR DRUG DISCOVERY; CONTENTS; Preface; Contributors; 1 Introduction to Pathway Analysis; 2 Software Infrastructure and Data Model for Pathway Analysis; 3 Automatic Pathway Inference in Heterogeneous Biological Association Networks; 4 Algorithmic Basis for Pathway Visualization; 5 Pathway Analysis of High-Throughput Experimental Data; 6 Integrative Pathway Analysis of Disease Molecular Data; 7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise; 8 Mammalian Proteome and Toxicant Network Analysis |
9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example10 Impact of Chemistry Information on Pathway Analysis; 11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks; 12 An Adaptive System Model of the Yeast Glucose Sensor System; 13 Present and Future of Pathway Analysis in Drug Discovery; Index |
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Sommario/riassunto |
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This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in rela |
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2. |
Record Nr. |
UNINA9910453400203321 |
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Autore |
Newson Linda A |
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Titolo |
From capture to sale : the Portuguese slave trade to Spanish South America in the early seventeenth century / / by Linda A. Newson, Susie Minchin |
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Pubbl/distr/stampa |
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Leiden ; ; Boston, : Brill, 2007 |
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ISBN |
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1-281-92116-5 |
9786611921163 |
90-474-1936-7 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (387 p.) |
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Collana |
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The Atlantic world, , 1570-0542 ; ; v. 12 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Slave trade - Portugal - History - 17th century |
Slave trade - South America - History - 17th century |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. [337]-355) and index. |
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Nota di contenuto |
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Preliminary Materials / L.A. Newson and S. Minchin -- Introduction / L.A. Newson and S. Minchin -- Chapter One. A Bureaucratic Business / L.A. Newson and S. Minchin -- Chapter Two. The Acquisition Of Slaves / L.A. Newson and S. Minchin -- Chapter Three. Time On The Coast / L.A. Newson and S. Minchin -- Chapter Four. The Middle Passage / L.A. Newson and S. Minchin -- Chapter Five. In The Barracoons Of Cartagena / L.A. Newson and S. Minchin -- Chapter Six. The Final Passage / L.A. Newson and S. Minchin -- Chapter Seven. Slave Doctors, Surgeons And Popular Healers / L.A. Newson and S. Minchin -- Chapter |
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Eight. Medicines And Mortality / L.A. Newson and S. Minchin -- Conclusion / L.A. Newson and S. Minchin -- Appendices / L.A. Newson and S. Minchin -- Glossary Of Spanish And Portuguese Terms / L.A. Newson and S. Minchin -- Bibliography / L.A. Newson and S. Minchin -- Index / L.A. Newson and S. Minchin. |
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Sommario/riassunto |
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From Capture to Sale illuminates the experience of African slaves transported to Spanish America by the Portuguese in the early seventeenth century. It draws on exceptionally rich accounts of one of the most prominent slave traders, Manuel Bautista Pérez. These papers cover the whole journey of the slaves from Africa, through Colombia and Panama to their final sale in Peru. The prime focus of the study is on the diet, health and medical care of the slaves. It will not only be of interest to scholars of the slave trade, but also to those interested in the impact of the Columbian Exchange on diets, medicine and medical practice in the early modern period. The book is well illustrated and contains over thirty tables and seven appendices. From Capture to Sale has been selected by Choice as Outstanding Academic Title (2007). |
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