| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910458652203321 |
|
|
Titolo |
Principles and practice of clinical research [[electronic resource] /] / [edited by] John I. Gallin, Frederick P. Ognibene |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Amsterdam ; ; Boston, : Elsevier/Academic Press, c2007 |
|
|
|
|
|
|
|
ISBN |
|
1-281-05227-2 |
9786611052270 |
0-08-048956-7 |
|
|
|
|
|
|
|
|
Edizione |
[2nd ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (447 p.) |
|
|
|
|
|
|
Altri autori (Persone) |
|
GallinJohn I |
OgnibeneFrederick P |
|
|
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
Clinical medicine - Research |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Prev. ed. cataloged as: Principles and practice of clinical research / John I. Gallin. |
|
|
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Front cover; Principles and Practice of Clinical Research; Copyright page; Table of contents; Preface; Acknowledgements; Contributors; Chapter 1: A Historical Perspective on Clinical Research; 1. THE EARLIEST CLINICAL RESEARCH; 2. THE GREEK AND ROMAN INFLUENCE; 3. MIDDLE AGES AND RENAISSANCE; 4. SEVENTEENTH CENTURY; 5. EIGHTEENTH CENTURY; 6. NINETEENTH CENTURY; 7. TWENTIETH CENTURY AND BEYOND; Acknowledgment; References and Notes; PART I: ETHICAL, REGULATORY, AND LEGAL ISSUES; Chapter 2: Ethical Principles in Clinical Research; 1. DISTINGUISHING CLINICAL RESEARCHFROM CLINICAL PRACTICE |
2. WHAT DOES ETHICS HAVE TO DOWITH CLINICAL RESEARCH?3. HISTORY OF ETHICAL ATTENTION TOCLINICAL RESEARCH; 4. CODES OF RESEARCH ETHICSAND REGULATIONS; 5. ETHICAL FRAMEWORK FORCLINICAL RESEARCH; 6. ETHICAL CONSIDERATIONS IN RANDOMIZED CLINICAL TRIALS; 7. CONCLUSION; References; Chapter 3: Researching a Bioethical Question; 1. TYPES OF BIOETHICAL ISSUES; 2. TYPES OF BIOETHICAL RESEARCH METHODOLOGIES; 3. EXAMPLES OF IMPORTANT BIOETHICAL RESEARCH; 4. SPECIAL CONSIDERATIONS INBIOETHICAL RESEARCH; References and Notes; Chapter 4: Integrity in Research: |
|
|
|
|
|
|
|
|
|
|
|
Individual and Institutional Responsibility |
1. GUIDELINES FOR THE CONDUCTOF RESEARCH2. SCIENTIFIC INTEGRITY AND MISCONDUCT; 3. MENTOR-TRAINEE RELATIONSHIPS; 4. DATA ACQUISITION, MANAGEMENT, SHARING, AND OWNERSHIP; 5. RESEARCH INVOLVING HUMAN AND ANIMAL SUBJECTS; 6. COLLABORATIVE SCIENCE; 7. CONFLICT OF INTEREST AND COMMITMENT; 8. PEER REVIEW; 9. PUBLICATION PRACTICES AND RESPONSIBLE AUTHORSHIP; Acknowledgment; References; Chapter 5: Institutional Review Boards; 1. HISTORICAL, ETHICAL, ANDREGULATORY FOUNDATIONSOF CURRENT REQUIREMENTSFOR RESEARCH INVOLVINGHUMAN SUBJECTS; 2. INSTITUTIONAL REVIEW BOARDS; 3. CLINICAL RESEARCHERSAND IRBs |
4. THE CURRENT IRB SYSTEM UNDER EVALUATION5. CONCLUSION; References and Notes; Chapter 6: Data and Safety Monitoring Boards; 1. DESCRIPTION OF THE DATA ANDSAFETY MONITORING BOARD; 2. DATA AND SAFETY MONITORINGBOARD FUNCTIONS; 3. DATA AND SAFETY MONITORINGBOARD DECISION MAKING; 4. EXAMPLES; 5. CONCLUSIONS; References; Chapter 7: Data Management in Clinical Trials; 1. THE RESEARCH TEAM; 2. PLANNING THE TRIAL; 3. WHERE ARE DATA?; 4. WHO CAN COLLECT DATA?; 5. SITE INITIATION VISIT; 6. INFORMED CONSENT; 7. ELIGIBILITY; 8. REGISTRATION; 9. WHAT DATA DO YOU COLLECT?; 10. TREATMENT PLAN |
11. CONCURRENT THERAPY12. ADVERSE EVENT MONITORING; 13. ROUTINE MONITORING VISITS; 14. AUDIT TRAIL; 15. ELECTRONIC DATABASE; 16. SUMMARY; References; Chapter 8: Unanticipated Risk in Clinical Research; 1. THE REASONS; 2. THE DRUG; 3. THE TARGET; 4. THE TRIALS; 5. CASSANDRA REVEALED; 6. EXTENDED STUDIES; 7. FIAU TOXICITY; 8. REASSESSING THEPRECLINICAL STUDIES; 9. RESEARCH OVERSIGHT; 10. THE INVESTIGATIONS BEGIN; 11. SCIENTIFIC MISCONDUCT; 12. THE FDA; 13. THE NATIONAL INSTITUTES OF HEALTH; 14. THE INSTITUTE OF MEDICINE; 15. THE MEDIA; 16. THE CONGRESS; 17. THE LAW; 18. EPILOGUE |
Acknowledgments |
|
|
|
|
|
|
Sommario/riassunto |
|
The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910453301103321 |
|
|
Autore |
Griffiths John |
|
|
Titolo |
Euthanasia and law in Europe / / John Griffiths and Heleen Weyers, Maurice Adams |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Oxford ; ; Portland, Oregon : , : Hart Publishing, , 2008 |
|
|
|
|
|
|
|
ISBN |
|
1-4725-6436-7 |
1-281-84700-3 |
9786611847005 |
1-84731-430-9 |
|
|
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (644 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Euthanasia - Law and legislation - Europe |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references (pages [533]-574) and index. |
|
|
|
|
|
|
Nota di contenuto |
|
1 Introduction -- PART I THE NETHERLANDS. 2 The Netherlands and the Dutch Health Care System ; 3 Recent Developments in Dutch Euthanasia Law ; 4 Dutch Law on Euthanasia and Other MBPSL ; 5 Dutch MBPSL Law in Context and in Practice ; 6 Termination of Life in Neonatology -- PART II BELGIUM. 7 Belgium and the Belgian Health Care System ; 8 The Legalisation of Euthanasia in Belgium ; 9 Belgian Law on Euthanasia and Other MBPSL ; 10 Belgian MBPSL Law in Context and in Practice -- PART III OTHER EUROPEAN COUNTRIES. 11 England and Wales ; 12 France ; 13 Italy ; 14 Scandinavia ; 15 Spain ; 16 Switzerland ; 17 Comparative Data -- PART IV THEMATIC REFLECTIONS. 18 The Nude Beach Phenomenon: Euthanasia and the Juridification of the Doctor Patient Relationship ; 19 Slithering Up the Slippery Slope ; 20 'Prediction is very difficult, especially about the future'. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
"This book is a successor to J Griffiths, A Bood and H Weyers, Euthanasia and Law in the Netherlands (Amsterdam University Press 1998) which was widely praised for its thoroughness, clarity, and accuracy. The new book emphasises recent legal developments and new research, and has been expanded to include a full treatment of |
|
|
|
|
|
|
|
|
|
|
Belgium, where since 2002 euthanasia has also become legal. The book also includes descriptions written by local specialists of the legal situation and what is known about actual practice in a number of other European countries (England and Wales, France, Italy, Scandinavia, Spain, Switzerland). The book strives for as complete and dispassionate a description of the situation as possible. It covers in detail: - the substantive law applicable to euthanasia, physician-assisted suicide, withholding and withdrawing treatment, use of pain relief in potentially lethal doses, palliative and terminal sedation, and termination of life without a request (in particular in the case of newborn babies); -the process of legal development that has led to the current state of the law; -the system of legal control and its operation in practice; -the results of empirical research concerning actual medical practice. A concluding part deals with some general questions that arise out of the material presented: Is the legalisation of euthanasia an example of the decline of law or should it, on the contrary, be seen as part and parcel of the increasing juridification of the doctor-patient relationship? Does the Dutch experience with legalised euthanasia support the idea of a 'slippery slope' toward a situation in which life-especially of the more vulnerable members of society-is less effectively protected? Is it possible to explain and to predict when a society will decide to legalise euthanasia?"--Bloomsbury Publishing. |
|
|
|
|
|
|
|
|
|
|
|
|
|
3. |
Record Nr. |
UNISA996201982503316 |
|
|
Titolo |
A companion to American fiction, 1780-1865 [[electronic resource] /] / edited by Shirley Samuels |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Malden, MA, : Blackwell Pub., 2004 |
|
|
|
|
|
|
|
ISBN |
|
1-78268-417-4 |
1-281-31267-3 |
9786611312671 |
1-4051-6511-1 |
0-470-99921-7 |
0-470-99920-9 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (488 p.) |
|
|
|
|
|
|
Collana |
|
Blackwell companions to literature and culture ; ; 24 |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
American fiction - 19th century - History and criticism |
American fiction - 18th century - History and criticism |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
A COMPANION TO AMERICAN FICTION; Contents; List of Illustrations; Notes on Contributors; Acknowledgments; Introduction; PART I Historical and Cultural Contexts; PART II Forms of Fiction; PART III Authors, Locations, Purposes; Index; |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
A Companion to American Fiction 1780-1865 presents current critical responses to the broad range of American fiction written from the earliest declarations of nationhood to secession and civil war. The volume features contributions from over 35 leading international critics and scholars, who offer a cultural and historical context that serves to illuminate the fiction. The Companion covers both less well-known writers, such as Lydia Maria Child and George Lippard, and canonical authors, such as Nathaniel Hawthorne, Herman Melville, and Harriet Beecher Stowe. Contributors demonstrate how these |
|
|
|
|
|
|
|
| |