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1. |
Record Nr. |
UNINA9910452746903321 |
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Titolo |
The 2012 nomination and the future of the Republican Party : the internal battle / / edited by William J. Miller |
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Pubbl/distr/stampa |
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Lanham : , : Lexington Books, , [2013] |
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©2013 |
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ISBN |
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1-4985-1507-X |
0-7391-7593-9 |
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Descrizione fisica |
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1 online resource (277 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Presidents - United States - Election - 2012 |
Presidential candidates - United States - History - 21st century |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographic references and index. |
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Nota di contenuto |
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Contents; Preface; Chapter One: The 2012 Republican Nomination Season: A Clown Car or Feuding Conservatives?; Chapter Two: The Impact of Rules Changes on the 2012 Republican Presidential Primary Process; Chapter Three: White Knights to the Rescue! The Non-Candidates of 2012; Chapter Four: The Curious Candidacy of Jon Huntsman; Chapter Five: Early to Rise, Early to Fall: The Short Lived Hope of Michele Bachmann; Chapter Six: The Hermanator: Anti-Elitism and the Rise of Herman Cain; Chapter Seven: Rick Perry: The Quickly Fading Star of Texas |
Chapter Eight: Newt Gingrich: It Takes More than Ideas to Win a NominationChapter Nine: Ron Paul: Establishment Outsider or Radical Insider?; Chapter Ten: Of Sweater Vests and Broken Dreams: Santorum's Almost Win; Chapter Eleven: Mitt Romney-The Republican Choice: Inevitability, Electability, and Lack of Enthusiasm; Chapter Twelve: The Victor's Reward and the Future of the GOP; About the Editor; About the Contributors; Index |
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Sommario/riassunto |
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If the 2012 nomination process taught the Republican Party anything, it is that there are internal fractures within the GOP that need to be worked out prior to the 2016 presidential election. When coupled with |
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changing national demographics that are less than favorable, Republican candidates must determine a way to bring together the pro-business, Tea Party, and evangelical wings of their party together if they hope for victory. |
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2. |
Record Nr. |
UNISA996499863803316 |
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Titolo |
Voltage-gated calcium channels / / Gerald Werner Zamponi and Norbert Weiss, editors |
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Pubbl/distr/stampa |
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Cham, Switzerland : , : Springer, , 2022 |
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©2005 |
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ISBN |
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Descrizione fisica |
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1 online resource (705 pages) |
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Disciplina |
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Soggetti |
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Calcium channels |
RNA editing |
Neurosciences |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Intro -- Preface -- Contents -- A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century -- Ca2+ as Central Ion for Muscle Contraction -- The "Ca-Spikes" of Crustacean Skeletal Muscles -- "Ca-Spikes" in Heart and Neurons -- How to Look at Ca2+ Currents Through Voltage-Clamp Recordings -- Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents -- A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells -- The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels -- The Discovery of the "Low-Voltage Activated" T-Type Channel -- The Unique Properties of T-Type (LVA) Channels -- The Explosive Interest on T-Type Channels -- The Ca2+ Channel Family Growths -- The N-Type Channel -- The P/Q-Type Channel -- The R-Type Channel -- From Ionic Currents to the Molecular Structure of Ca2+ Channels -- The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ |
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Channel Modulation -- Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels -- Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels -- Looking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins -- Take-Home Message -- References -- Part I: Structural and Molecular Aspects of VGCCs -- Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels -- Introduction -- Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels -- Structures of NaVAb and CaVAb Channels -- Structure of the Skeletal Muscle CaV1.1 Calcium Channel -- Molecular Properties of the CaV2 Family of Calcium Channels -- Structure of CaV2.2 Calcium Channels and Implications for Regulation -- Molecular Properties and Structure of CaV3 Calcium Channels -- Pharmacology of Calcium Channels -- Conclusion -- References. |
Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels -- Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing -- Splice Variations in High Voltage-Activated Calcium Channels -- CaV1.1 Splice Variant in Myotonic Dystrophy -- CaV1.2 Splice Variants in Health and Disease -- Exon 9* in Cardiovascular Diseases -- Mutually Exclusive Exons 1a/1 and Exons 8a/8 -- Exons 21/22 -- Exon 33 and Exon 33L -- CaV1.3 in Health and Disease -- The Pathophysiological Roles of CaV1.3 -- The Unique Biophysical and Pharmacological Properties of CaV1.3 Channels and Modulation -- Regulation of α1D Transcripts by Alternative Splicing and A-to-I RNA Editing -- CaV1.4 in Health and Disease -- Structure-Function Relationship Learnt from Human Mutations and Alternative Splicing Patterns -- The CaV2 Channel Family -- Pathophysiological Roles of CaV2 Channel Family -- Alternative Splicing in CaV2 Channel Family -- Exon 37 -- Exon 43/44 -- Exon 47 -- Novel Approaches to Uncover the Pathophysiological Consequences of Alternative Splicing or Gene Mutations of Ion Channels: Moving Away from Heterologous Systems -- Summary -- References -- Voltage-Gated Calcium Channel Auxiliary β Subunits -- Physiological Roles of High-Voltage-Activated Calcium Channels -- Subunits of Voltage-Gated Calcium Channels -- Physiological Roles of CaVβ Subunits -- Functional Effects of CaVβ Subunits in HVACC Complexes -- CaVβ Regulation of HVACC Membrane Trafficking -- CaVβ Regulation of HVACC Activation Gating -- CaVβ Regulation of HVACC Open Probability -- CaVβ Regulation of HVACC Inactivation Gating -- Structure-Function of CaVβ Regulation of HVACCs -- CaVβ-Interacting Proteins That Regulate HVACCs -- Regulation of HVACCs by RGK Proteins -- Roles of CaVβ and Rad in Sympathetic Regulation of Cardiac CaV1.2 -- RIM-Binding Protein Regulation of HVACCs. |
Association of CaVβ Subunits with Disease -- Pharmacological Targeting of CaVβ Subunits -- References -- Regulation of Calcium Channels and Synaptic Function by Auxiliary α2δ Subunits -- Introduction -- Discovery of α2δ Subunits -- Identification of α2δ Subunits -- Cloning -- Splice Variants -- Tissue Distribution of α2δ Subunits -- α2δ-1 -- α2δ-2 -- α2δ-3 -- α2δ-4 -- Structure of α2δ Subunits -- Biochemical and Bioinformatic Studies -- GPI Anchoring -- VWA Domain -- Cache Domains -- Proteolytic Maturation of α2δ -- Cachd1 Protein -- Molecular Structure of α2δ-1 -- Functions of α2δ Subunits as Calcium Channel Subunits -- Effects of Cloned α2δ Subunits on Calcium Currents -- Effects of α2δ Subunits on Biophysical Properties of Calcium Currents -- Effects of α2δ Subunits on Calcium Channel Trafficking -- Cachd1 Function -- Synaptic Functions of α2δ Proteins Beyond Their Role as Calcium Channel Subunits -- Importance of α2δ Proteins in Neuronal and Synaptic Functions -- Postsynaptic |
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Functions of α2δ-1 -- Presynaptic and Trans-synaptic Roles of α2δ Proteins -- Diseases Associated with α2δ Subunits -- Ducky Mice and Human Mutations of the α2δ-2 Gene -- Mutations in the α2δ-1 Gene Associated with Cardiac Phenotypes -- Neuropathic Injury and the Role of α2δ-1 -- Disorders Associated with α2δ-3 -- Disorders Associated with α2δ-4 -- Psychiatric Disorders -- Pharmacology Involving α2δ Subunits -- Therapeutic Uses of Gabapentinoids -- Gabapentinoid Drug Binding to α2δ Subunits and Potential Mechanisms of Action -- The First Double Cache Domain in α2δ-1 Has Structural Homology to a Universal Amino Acid Binding Domain -- Effect of α2δ Subunits on Ziconotide Binding -- Other Interactions of α2δ Proteins -- Summary and Outlook -- References -- Voltage-Gated Calcium Channels in Invertebrates -- Introduction: Invertebrates and Calcium Channel Discovery. |
Phylogenetic Properties of the CaV Channel α1 Subunit -- Phylogenetic Properties of the CaV Channel β Subunit -- Phylogenetic Properties of the CaV Channel α2δ Subunit -- CaV Channels in Deuterostome Invertebrates -- Since Hagiwara's Discovery of LVA and HVA Ca2+ Currents in Starfish Eggs -- Tunicates and the Evolution of CaV1.1 Channels and Ryanodine Receptor Tetrad Coupling -- CaV Channels in Protostome Invertebrates -- The Atypical Nature of Calcium Channels in Parasitic Flatworms -- Functional Studies of Calcium Channels of the Pond Snail Lymnaea Stagnalis -- Genetic Studies of Ecdysozoan β and α2δ Subunits Highlight Gene Duplication as a Mechanism for Functional Diversification and the Emergence of Pleiotropic Functions -- Genetic and Functional Studies of Ecdysozoan CaV1-CaV3 Channels Reveal Deep Conservation of C-Terminal Protein Interactions and Sub-cellular Localization -- CaV Channels in Early-Diverging Animals -- Cnidaria: Our Most Distant Neural Ancestors? -- Evolutionary Insights from Functional Studies of the Placozoan CaV1 to CaV3 Channels -- A Calcium Channel Regulates Choanocyte Ciliary Beating and the Feeding Current in Sponges -- Ctenophores -- Conclusions -- References -- Untitled -- Part II: Regulation of VGCCs -- Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers -- Introduction -- Modulation of Cav1 Channels by GPCRs and Second Messengers -- β-Adrenergic Modulation of L-Type Channels: Activation of the Gs Signaling Pathway -- Gq-Coupled GPCR Modulation of L-Type Channels -- Gi/o-Coupled GPCR Modulation of L-Type Channels -- GPCR-Mediated Modulation of Cav1.4 in the Retina -- Modulation of Cav2 Channels by GPCRs and Second Messengers -- Mechanisms Gi/o Mediated Inhibition: Fast, Direct, Voltage-Dependent -- Cav2 Channel Interaction Sites with Gβγ Subunits. |
Gβγ and Cavβ Subunit Diversity and Interaction Sites with Cav2 Channels -- Modulation of G Protein-Mediated Inhibition by Synaptic Associated and Other Proteins -- Regulation of Cav2 Channels by Lipids -- Mechanisms of Gq/11-Mediated Inhibition: Slow, Indirect, Voltage-Independent -- Conclusion for Cav2 Channels -- Modulation of Cav3 Channels by GPCRs and Second Messengers -- Direct Modulation by Gβγ Subunits -- Modulation by Kinases -- Protein Kinase A -- Protein Kinase C -- Calmodulin-Dependent Kinase II -- Protein Kinase G -- Rho-Kinase -- Tyrosine Kinase -- GPCR-Mediated Change in T-Type Channel Expression -- Conclusion for T-Type Channels -- Summary -- References -- Trafficking of Neuronal Calcium Channels -- Introduction -- Regulation of VGCCs by Ancillary Subunits -- Cavβ-Subunit -- Cavα2δ-Subunit -- Cavγ-Subunit -- Regulation of VGCCs by Other Interacting Proteins -- Calmodulin -- Collapsin Response Mediator Proteins -- Stac Adaptor Proteins -- |
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Kelch-like 1 -- Calnexin -- Secretory Carrier-Associated Membrane Proteins -- Receptor for Activated C kinase 1 -- Regulation of VGCCs by Posttranslational Modifications -- Ubiquitination -- Glycosylation -- Subcellular Targeting of VGCCs -- Concluding Remarks and Perspectives -- References -- Calmodulin Regulation of Voltage-Gated Calcium Channels -- Introduction -- Ca2+/CaM-Dependent Regulation of VGCCs -- Ca2+/CaM-Dependent Regulation Responds Differentially to Spatially Distinct Ca2+ Sources -- Molecular Mechanism of Calmodulation -- Ca2+ Regulation of VGCCs in Disease -- References -- Cav3 Calcium Channel Interactions with Potassium Channels -- Introduction -- Cav3-Kv4 Complex -- Cav3.2-IK Complex -- Cav3.2-BK Complex -- Perspectives and Conclusions -- References -- Part III: (Patho)physiology of VGCCs -- Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Mice -- Introduction -- CaV1. |
CaV1.1. |
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3. |
Record Nr. |
UNINA9910779073603321 |
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Autore |
Boekaerts Monique |
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Titolo |
Handbook of Self-Regulation [[electronic resource]] |
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Pubbl/distr/stampa |
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Burlington, : Elsevier Science, 2005 |
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ISBN |
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1-283-44782-7 |
9786613447821 |
0-08-057549-8 |
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Descrizione fisica |
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1 online resource (814 p.) |
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Altri autori (Persone) |
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PintrichPaul R |
ZeidnerMoshe |
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Disciplina |
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Soggetti |
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Psychology |
Self-control |
Self-Regulation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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Front Cover; Handbook of Self-Regulation; Copyright Page; Table of |
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Contents; FOREWORD; ABOUT THE EDITORS; CONTRIBUTORS; Chapter 1. SELF-REGULATION: AN INTRODUCTORY OVERVIEW; PART I: GENERAL THEORIES AND MODELS OF SELF-REGULATION; Chapter 2. ATTAINING SELF-REGULATION: A SOCIAL COGNITIVE PERSPECTIVE; I. INTRODUCTION; II. THE STRUCTURE OF SELF-REGULATORY SYSTEMS; III. SOCIAL AND ENVIRONMENTAL INFLUENCES ON SELF-REGULATION; IV. DYSFUNCTIONS IN SELF-REGULATION; V. DEVELOPMENT OF SELF-REGULATORY SKILL; VI. FUTURE RESEARCH DIRECTIONS; VII. A CONCLUDING COMMENT |
Chapter 3. ON THE STRUCTURE OF BEHAVIORAL SELF- REGULATIONI. BEHAVIOR IS GOAL DIRECTED AND FEEDBACK CONTROLLED; II. HIERARCHICALITY AMONG GOALS; III. FEEDBACK CONTROL AND CREATION OF AFFECT; IV. CONFIDENCE AND DOUBT, PERSISTENCE AND GIVING UP; V. DYNAMIC SYSTEMS AND HUMAN BEHAVIOR; VI. CATASTROPHE THEORY; VII. CONCLUDING COMMENT; Chapter 4. ASPECTS OF GOAL NETWORKS: IMPLICATIONS FOR SELF-REGULATION; I. A STRUCTURAL ANALYSIS OF GOAL NETWORKS; II. SELF-REGULATORY CONSEQUENCES OF GOAL NETWORK STRUCTURE; III. INDIVIDUAL DIFFERENCES IN THE STRUCTURE OF GOALS AND MEANS |
IV. COMPARISON TO OTHER PERSPECTIVES ON GOAL NETWORKSV. FUTURE DIRECTIONS: INTERPERSONAL GOALS; VI. CONCLUSION; Chapter 5. A FUNCTIONAL-DESIGN APPROACH TO MOTIVATION AND SELF-REGULATION: THE DYNAMICS OF PERSONALITY SYSTEMS AND INTERACTIONS; I. INTRODUCTION; II. DYNAMIC CONCEPTS IN CLASSICAL THEORIES OF MOTIVATION; III. ARISTOTLE'S DYNAMIC CONCEPTS; IV. PERSONALITY SYSTEMS INTERACTION THEORY; V. BACK TO THE FUTURE: FROM CONTENTS TO MECHANISMS; VI. CONCLUSION; Chapter 6. PERSONALITY, SELF- REGULATION, AND ADAPTATION: A COGN ITIVE - SOCIAL FRAMEWORK |
I. FRAMEWORKS FOR PERSONALITY AND SELF-REGULATION RESEARCHII. SELF-REGULATION, TRAITS, AND COGNITIVE STRESS PROCESSES; III. PERSONALITY AND SELF-REGULATION OF REACTIONS TO LIFE STRESS; IV. PERSONALITY AND SELF-REGULATION IN PERFORMANCE ENVIRONMENTS; V. AGGRESSIVE BEHAVIOR; VI. CONCLUSIONS; Chapter 7. ORGANIZATION AND DEVELOPMENT OF SELF-UNDERSTANDING AND SELF-REGULATION: TOWARD A GENERAL THEORY; I. INTRODUCTION; II. THE ARCHITECTURE OF SELF-AWARE AND SELF-REGULATED SYSTEMS; III. DEVELOPMENT OF SELF-UNDERSTANDING AND SELF-REGULATION |
IV. EXPLAINING THE DEVELOPMENT OF SELF-UNDERSTANDING AND SELF-REGULATIONV. CONCLUSIONS; Chapter 8. THE ROLE OF INTENTION IN SELF-REGULATION: TOWARD INTENTIONAL SYSTEMIC MINDFULNESS; I. SYSTEMS THEORY, SELF-REGULATION, AND MINDFULNESS; II. SELF-REGULATION; III. SELF-REGULATION TECHNIQUES AND POTENTIAL LIMITATIONS; IV. PSYCHOPHYSIOLOGICAL RESEARCH ON SELF-REGULATION - PHYSIOLOGY AND ENERGY; V. ELABORATION OF AN EXPANDED SELF-REGULATION MODEL: INTENTION; VI. INTENTION; VII. INTENTIONAL SYSTEMIC MINDFULNESS: MINDFULNESS QUALITIES AND SYSTEMIC PERSPECTIVES |
VIII. APPLICATIONS OF INTENTIONAL SYSTEMIC MINDFULNESS TO SELF-REGULATION TECHNIQUES |
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Sommario/riassunto |
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Handbook of Self-Regulation |
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4. |
Record Nr. |
UNIORUON00513725 |
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Autore |
KAWATAKE Shigetoshi |
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Titolo |
Kabuki tokuhon / Kawatake Shigetoshi |
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Pubbl/distr/stampa |
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Edizione |
[2. ed] |
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Descrizione fisica |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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