Record Nr.

UNINA9910451715203321

Autore

Neidle Stephen

Titolo

Cancer drug design and discovery [[electronic resource] /] / Stephen Neidle

Pubbl/distr/stampa


London, : Academic, c2008

ISBN

1-281-76368-3

9786611763688

0-08-055495-4

Descrizione fisica

1 online resource (517 p.)

Disciplina

616.994061

Soggetti

Antineoplastic agents - Development

Antineoplastic agents - Design

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Front Cover; Cancer Drug Design and Discovery; Copyright Page; Contents; About the editor; Contributors; Introduction; PART I: BASIC PRINCIPLES; Chapter 1 Modern cancer drug discovery: integrating targets, technologies and treatments; 1.1 Introduction: changing times; 1.2 Successes and limitations; 1.3 Integrated small-molecule drug discovery and development; 1.4 New molecular targets: the ""druggable"" cancer genome; 1.5 From drug target to development candidate; 1.6 Examples of case histories for molecularly targeted cancer therapeutics

1.7 Biomarkers, the pharmacological audit trail and clinical development1.8 Conclusions and outlook: towards individualized molecular cancer medicine; References; Chapter 2 Preclinical pharmacology and in vivo models; 2.1 Introduction; 2.2 Contemporary preclinical cancer drug discovery; 2.3 In vitro pharmacological evaluation; 2.4 Information gained from in vitro cell lines; 2.5 In vivo pharmacokinetics (PK) and pharmacodynamics (PD): continuing the pharmacological audit trail; 2.6 In vivo anti-tumor models: choice and predictiveness?; 2.7 Concluding remarks; References

Chapter 3 Clinical trial designs for more rapid proof-of-principle and

approval3.1 Introduction; 3.2 NDA plan at the time of IND; 3.3 Phase I trial design innovations; 3.4 Concept of a continuous Phase I; 3.5 Phase II trial design innovations; 3.6 Phase III trial design innovations (enrichment designs); 3.7 Other approaches to enrich trial populations; 3.8 Innovations in design and selection of endpoints; 3.9 Regulatory strategies; 3.10 Other approaches to accelerate drug development; 3.11 New perspectives; 3.12 Summary; References; PART II: METHODOLOGY

Chapter 4 Structural biology and anticancer drug design4.1 Introduction; 4.2 High-throughput X-ray crystallography; 4.3 Structural biology and structure-based drug design; 4.4 Fragment screening using X-ray crystallography; 4.5 Case history: cyclin-dependent kinase inhibitors, from fragment hit to clinical candidate; 4.6 Compound profiling; 4.7 Conclusions; References; Chapter 5 Natural product chemistry and anticancer drug discovery; 5.1 Introduction; 5.2 Exemestane (aromasin); 5.3 Fulvestrant/faslodex; 5.4 Flavonoids; 5.5 Bexarotene (targretin); 5.6 Epothilones; 5.7 Maytansine

5.8 Geldanamycin5.9 UCN-01; 5.10 Camptothecin; 5.11 Prodigiosin; 5.12 Azacitidine; 5.13 FK-288; 5.14 Hemiasterlin; 5.15 Calicheamicin; 5.16 Conclusion; References; Chapter 6 Pharmacokinetics and ADME optimization in drug discovery; 6.1 Introduction; 6.2 Absorption; 6.3 Distribution; 6.4 Metabolism; 6.5 Elimination; 6.6 Biochemical barriers to drug therapy: efflux transporters; 6.7 Induction; 6.8 Conclusions; References; PART III: DRUGS IN THE CLINIC; Chapter 7 Temozolomide: from cytotoxic to molecularly-targeted agent; 7.1 Introduction

7.2 Towards imidazotetrazines and azolastone (mitozolomide)

Sommario/riassunto

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference fo

Record Nr.

UNINA9910707029003321

Titolo

Drug Free Commercial Driver Act of 2015 : report of the Committee on Commerce, Science and Transportation on S. 806

Pubbl/distr/stampa


Washington : , : U.S. Government Publishing Office, , 2016

Descrizione fisica

1 online resource (ii, 8 pages)

Collana

Report / 114th Congress, 2d session, Senate ; ; 114-232

Soggetti

Professional motor vehicle drivers - Drug testing - United States

Hair - Analysis

Employee screening - Law and legislation - United States

Drug testing - Law and legislation - United States

Legislative materials.