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1. |
Record Nr. |
UNINA9910451573503321 |
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Autore |
Killeen Matthew J |
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Titolo |
Cardiac drug safety [[electronic resource] ] : a bench to bedside approach / / Matthew J. Killeen |
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Pubbl/distr/stampa |
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Singapore, : World Scientific Pub. Co., 2012 |
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ISBN |
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1-280-66922-5 |
9786613646156 |
981-4317-46-2 |
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Descrizione fisica |
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1 online resource (189 p.) |
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Disciplina |
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363.738/74 |
363.73874 |
615.71 |
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Soggetti |
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Cardiovascular agents |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Foreword; "Et causae quoque aestimatio saepe morbum solvit"* [Celsus: Prooemium 69, De Medicina]; Preface; Chapter 1 Challenges Facing the Pharmaceutical Industry in the 21st Century; Introduction; The Impact of Cardiac Toxicity on the Pharmaceutical Industry; References; Chapter 2 The Cellular Basis of Cardiac Electrophysiology; Introduction; The Initiation of the Heart Beat; The Ventricular Cardiac Action Potential; The Relationship Between the Cardiac Action Potential and the Electrocardiogram; Ion Channels Underlying the Cardiac Action Potential; Sodium channels |
Calcium channels Potassium channels; Cardiac potassium channels; The transient outward potassium channel; Delayed rectifier potassium channels; The ultra rapid delayed rectifier potassium channel; The HERG potassium channel; The slowly activating delayed rectifier potassium channel; Inwardly rectifying potassium channels; Species-dependent variability of potassium channels; Potassium channel subunits; Summary; References; Chapter 3 Clinical Arrhythmia Syndromes; Introduction; The Long QT Syndrome; Congenital Long QT Syndrome; Drug-Induced QT Prolongation; Summary; References |
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Chapter 4 The Mechanisms Underlying Cardiac Arrhythmias Introduction; Mechanisms Underlying Cardiac Arrhythmias; Abnormal Automaticity; Early and Delayed After depolarizations; Re-entry; Transmural Dispersion of Repolarization; How does Action Potential and QT Prolongation Generate Arrhythmias?; Does the M-Cell Play a Role in Arrhythmia Induction in Humans?; Using Mouse Models to Study Arrhythmia Mechanisms; Experimental Studies Exploring the Relationship Between Changes in Transmural Repolarization Gradients and Arrhythmias in Mouse Hearts |
Arrhythmia Mechanisms and Novel Antiarrhythmic Approaches Identified Using the Hypokalemic Mouse Model Summary; References; Chapter 5 The Mechanisms Underlying Drug-Induced Arrhythmias; Introduction; The Classical Model of Drug-Induced QT Prolongation and Proarrhythmia: HERG Blockade; Additional Mechanisms Contributing to Drug-Induced Arrhythmias; Drug-Induction Activation of Depolarizing Ion Channels; Drug-Induced Changes in Ion Channel Expression; Drug-Induced Sodium Channel Dysfunction; Summary; References; Chapter 6 Assessing Cardiac Safety in Drug Development; Introduction |
Preclinical Evaluation of Cardiac Drug Safety The ICH S7B Guidelines; Single Cell Safety Studies; The Purkinje Fiber Model; The Ventricular Wedge Model; Isolated Heart Models; In Vivo Models; The Impact of Species-Related Differences in Cardiac Electrophysiology on Preclinical Drug Safety Assessment; Methods to Provoke Arrhythmias in Preclinical Studies; Programmed electrical stimulation; Reductions in the extracellular K+ concentration; Clinical Evaluation of Cardiac Safety; The Thorough QT study; Thorough QT study design; Additional Biomarkers to Detect Drug-Induced Proarrhythmia |
Variability of repolarization |
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Sommario/riassunto |
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Ensuring the safety of new medical products remains a major challenge for the pharmaceutical industry. Cardiac safety, particularly drug-induced heart rhythm abnormalities, remains an important cause of pipeline attrition and has resulted in countless major product recalls or label changes. The risk of encountering this major adverse event continues to shape the drug development and regulatory landscape. Extensive research over the past decade has shed light on the root causes of arrhythmias that are triggered by medications and has helped drive, and optimize, drug safety testing.However, |
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2. |
Record Nr. |
UNINA9910797654503321 |
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Autore |
Tessone Natasha <1971-> |
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Titolo |
Disputed titles : Ireland, Scotland, and the novel of inheritance, 1798-1832 / / Natasha Tessone |
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Pubbl/distr/stampa |
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Lanham, Maryland : , : Bucknell University Press : , : Copublished by The Rowman & Littlefield Publishing Group, Incorporated, , [2015] |
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©2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (255 p.) |
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Collana |
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Transits: literature, thought & culture, 1650-1850 |
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Disciplina |
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Soggetti |
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English fiction - 18th century - History and criticism |
English fiction - 19th century - History and criticism |
Inheritance and succession in literature |
Romanticism - Great Britain |
Ireland In literature |
Scotland In literature |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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CONTENTS; ACKNOWLEDGMENTS; INTRODUCTION. Inheriting the Novel; CHAPTER 1. "MEMENTI OF ANCIENT NATIONAL SPLENDOUR": Sydney Owenson's Ireland; CHAPTER 2. PROPHESYING THE PAST: Guy Mannering and Scott's Grid of Inheritance; CHAPTER 3. "ARRESTING FLEETING PROPERTY": Inheritance and the (Il)legitimacy of Historical Discourse in Scott's The Antiquary; CHAPTER 4. INHERITANCE OF BLUNDER: Maria Edgeworth's Ireland; CHAPTER 5. FIELDING FIELDING: Irish Tom Jones and a Plea for Passion in Maria Edgeworth's Ormond; CHAPTER 6. A "FRAUD AGAINST NATURE": John Galt's The Entail; NOTES; BIBLIOGRAPHY; INDEX |
ABOUT THE AUTHOR |
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Sommario/riassunto |
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Disputed Titles illuminates the ways in which inheritance shaped British novels of the Romantic period allowing them to negotiate the broader concerns of religious, ethnic, and national identities. It examines legal and material practices of inheritance and traces how the political and discursive implications developed of inheritance in discrete but parallel |
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ways in both Ireland and Scotland since the "Glorious" Revolution, through the Jacobite Uprisings, the French Revolution, the Napoleonic Wars, and up to the Reform Act. |
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3. |
Record Nr. |
UNINA9910144159303321 |
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Titolo |
Journal of ethnopharmacology |
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Pubbl/distr/stampa |
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Amsterdam ; ; New York, : Elsevier |
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ISSN |
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Soggetti |
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Pharmacognosy |
Herbs |
Angiosperms |
Magnoliopsida |
Herbal Medicine |
Pharmacognosie |
Herbes |
Angiospermes |
Angiospermae (division) |
periodicals. |
Periodicals. |
Périodiques. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Periodico |
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Note generali |
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Sommario/riassunto |
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"An interdisciplinary journal devoted to bioscientific research on indigenous drugs." |
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