1.

Record Nr.

UNINA9910451288903321

Titolo

Using CNS autopsy tissue in psychiatric research : a practical guide / / edited by Brian Dean, Joel E. Kleinman and Thomas M. Hyde

Pubbl/distr/stampa

Amsterdam : , : Harwood Academic Publishers, , 1999

ISBN

0-429-27124-7

1-4822-8341-7

1-280-07237-7

0-203-30427-6

9786610072378

Descrizione fisica

1 online resource (188 p.)

Altri autori (Persone)

DeanBrian, Dr.

HydeThomas M <1957-> (Thomas Michael)

KleinmanJoel E. <1945->

Disciplina

611.0188

Soggetti

Psychiatry - Research

Neuropsychiatry

Electronic books.

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Book Cover; Title; Contents; Foreword; Contributors; The Collection of Tissue at Autopsy: Practical and Ethical Issues; Psychiatric Diagnosis After Death: The Problems of Accurate Diagnosis from Case History Review and Relative Interviews; Membrane Binding Assays: Membrane Preparation and Assay Development; The Localisation and Quantification of Molecular Changes in the Human Brain Using In Situ Radioligand Binding and Autoradiography; In Situ Hybridisation Histochemistry: Application to Human Brain Tissue; Immunohistochemistry Techniques Applicable for Use with Human Brain Tissue

The Processing and Use of Postmortem Human Brain Tissue for Electron MicroscopyIsolating Components of Human Brain: The Purification of A and the Alzheimer's Amyloid Precursor Protein; Analysis of Receptor Systems in Schizophrenia Using Tissue Obtained at Autopsy and Neuroimaging; Index



Sommario/riassunto

Essential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtained at autopsy into studies in living brain by using neuroimaging techniques. In addition, the reader is directed to suppliers of equipment and reagents that have been shown to be useful when studying human brain tissue.