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Record Nr. |
UNINA9910450803003321 |
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Autore |
Crichton Robert R |
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Titolo |
Biological inorganic chemistry [[electronic resource] ] : an introduction / / Robert R. Crichton with the collaboration of Fre deric Lallemand, Ionna S.M. Psalti and Roberta J Ward |
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Pubbl/distr/stampa |
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Amsterdam ; ; Oxford, : Elsevier, 2008 |
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ISBN |
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1-281-11215-1 |
9786611112158 |
0-08-055622-1 |
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Descrizione fisica |
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1 online resource (383 p.) |
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Disciplina |
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Soggetti |
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Bioinorganic chemistry |
Chemistry, Inorganic |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front cover; Biological Inorganic Chemistry An Introduction; Copyright page; Preface; Contents; Chapter 1. An Overview of Metals in Biology; Introduction; Why do we Need Anything Other Than C, H, N and O (Together with Some P And S)?; What are the Essential Metal Ions?; References; Chapter 2. Basic Coordination Chemistry for Biologists; Introduction; Hard and Soft Ligands; Coordination Geometry; Crystal Field Theory and Ligand Field Theory; References; Chapter 3. Biological Ligands for Metal Ions; Introduction; Protein Amino Acid Residues (and Derivatives) as Ligands |
An Example of a Non-Protein Ligand: Carbonate and PhosphateEngineering Metal Insertion Into Organic Cofactors; Chelatase: Terminal Step in Tetrapyrrole Metallation; Iron-Sulfur Cluster Containing Proteins; Iron-Sulfur Cluster Formation; Copper Insertion into Superoxide Dismutase; More Complex Cofactors: MoCo, FeMoCo, P-Clusters, H-Clusters and CuZ; Siderophores; References; Chapter 4. Structural and Molecular Biology for Chemists; Introduction; The Structural Building Blocks of Proteins; Primary, Secondary, Tertiary and Quaternary Structures of Proteins |
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Secondary and Tertiary Structures of Nucleic AcidsReferences; Chapter 5. An Overview of Intermediary Metabolism and Bioenergetics; Introduction; Redox Reactions in Metabolism; The Central Role of ATP in Metabolism; The Types of Reaction Catalysed by Enzymes of Intermediary Metabolism; An Overview of Intermediary Metabolism: Catabolism; Selected Case Studies: Glycolysis and the Tricarboxylic Acid Cycle; An Overview of Intermediary Metabolism: Anabolism; Bioenergetics: Generation of Phosphoryl Transfer Potential at the Expense of Proton Gradients; References |
Chapter 6. Methods to Study Metals in Biological SystemsIntroduction; Magnetic Properties; Electron Paramagnetic Resonance (EPR) Spectroscopy; Mössbauer Spectroscopy; NMR Spectroscopy; Electronic and Vibrational Spectroscopies; Circular Dichroism and Magnetic Circular Dichroism; Resonance Raman Spectroscopy; Extended X-Ray Absorption Fine Structure; X-Ray Diffraction; References; Chapter 7. Metal Assimilation Pathways; Introduction; Metal Assimilation in Bacteria; Metal Assimilation in Plants and Fungi; Metal Assimilation in Mammals; References |
Chapter 8. Transport, Storage and Homeostasis of Metal IonsIntroduction; Metal Storage and Homeostasis in Bacteria; Metal Transport, Storage and Homeostasis in Plants and Fungi; Metal Transport, Storage and Homeostasis in Mammals; References; Chapter 9. Sodium and Potassium-Channels and Pumps; Introduction: -Transport Across Membranes; Sodium Versuspotassium; Sodium Channels; References; Chapter 10. Magnesium-Phosphate Metabolism and Photoreceptors; Introduction; Magnesium-Dependent Enzymes; Phosphoryl Group Transfer: Kinases; Phosphoryl Group Transfer: Phosphatases |
Stabilization of Enolate Anions: The Enolase Super Family |
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Sommario/riassunto |
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The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of th |
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