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Record Nr. |
UNINA9910450497003321 |
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Autore |
Baldi Pierre |
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Titolo |
DNA microarrays and gene expression / / Pierre Baldi and G. Wesley Hatfield [[electronic resource]] |
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Pubbl/distr/stampa |
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Cambridge : , : Cambridge University Press, , 2002 |
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ISBN |
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1-107-13017-4 |
1-280-16041-1 |
9786610160419 |
0-511-06321-0 |
0-511-11922-4 |
1-139-14694-7 |
0-511-05688-5 |
0-511-32267-4 |
0-511-54177-5 |
0-511-07167-1 |
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Descrizione fisica |
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1 online resource (xvi, 213 pages) : digital, PDF file(s) |
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Disciplina |
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Soggetti |
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DNA microarrays |
Gene expression |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Title from publisher's bibliographic system (viewed on 05 Oct 2015). |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover; Half-title; Title; Copyright; Contents; Preface; 1 A brief history of genomics; 2 DNA array formats; 3 DNA array readout methods; 4 Gene expression profiling experiments: Problems, pitfalls, and solutions; 5 Statistical analysis of array data: Inferring changes; 6 Statistical analysis of array data: Dimensionality reduction,clustering,and regulatory regions; 7 The design, analysis,and interpretation of gene expression profiling experiments; 8 Systems biology; Appendix A; Appendix B; Appendix C; Appendix D; Index |
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Sommario/riassunto |
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Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can |
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provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology. |
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