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Record Nr. |
UNINA9910450162003321 |
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Titolo |
Drug design [[electronic resource] ] : cutting edge approaches / / edited by Darren R. Flower |
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Pubbl/distr/stampa |
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Cambridge, U.K., : Royal Society of Chemistry, c2002 |
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ISBN |
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1-84755-070-3 |
1-60119-027-1 |
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Descrizione fisica |
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1 online resource (204 p.) |
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Collana |
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Special publication ; ; no. 279 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Drugs - Design |
Drugs - Design - Mathematical models |
Artificial intelligence - Medical applications |
Drugs - Research - Methodology |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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"Proceedings of the meeting on Cutting Edge Approaches to Drug Design held on 13 March 2001 at the Scientific Societies Lecture Theatre, London, UK"--T.p. verso. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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CONTENTS; Molecular Informatics: Sharpening Drug Design's Cutting Edge; High-Throughput X-Ray Crystallography for Drug Discovery; Trawling the Genome for G Protein-coupled Receptors: the Importance of Integrating Bioinformatic Approaches; Virtual Screening of Virtual Libraries - an Efficient Strategy for LeadGeneration; Virtual Techniques for Lead Optimisation; The Impact of Physical Organic Chemistry on the Control of Drug-likeProperties; Mutagenesis and Modelling Highlight the Critical Nature of theTM2-loop-TM3 Region of Biogenic Amine GPCRS; Computational Vaccine Design; Subject Index |
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Sommario/riassunto |
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Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G- |
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