| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910449973303321 |
|
|
Autore |
Urban Hugh B. |
|
|
Titolo |
Tantra : Sex, Secrecy, Politics, and Power in the Study of Religion / / Hugh B. Urban |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Berkeley, CA : , : University of California Press, , [2003] |
|
©2003 |
|
|
|
|
|
|
|
|
|
ISBN |
|
1-282-35961-4 |
1-59734-932-1 |
9786612359613 |
9781417525533 |
0-520-93689-2 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (390 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Tantric Buddhism |
Tantrism |
Electronic books. |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references (p. 337-366) and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Front matter -- Contents -- Illustrations -- Preface and Acknowledgments -- Abbreviations -- Introduction: Diagnosing the "Disease" of Tantra -- 1. The Golden Age of the Vedas and the Dark Age of Kàlí: Tantrism, Orientalism, and the Bengal Renaissance -- 2. Sacrificing White Goats to the Goddess: Tantra and Political Violence in Colonial India -- 3. India's Darkest Heart: Tantra in the Literary Imagination -- 4. Deodorized Tantra: Sex, Scandal, Secrecy, and Censorship in the Works of John Woodroffe and Swami Vivekananda -- 5. Religion for the Age of Darkness: Tantra and the History of Religions in the Twentieth Century -- 6. The Cult of Ecstasy: Meldings of East and West in a New Age of Tantra -- Conclusion -- Notes -- Bibliography -- Index |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
A complex body of religious practices that spread throughout the Hindu, Buddhist, and Jain traditions; a form of spirituality that |
|
|
|
|
|
|
|
|
|
|
|
|
|
seemingly combines sexuality, sensual pleasure, and the full range of physical experience with the religious life-Tantra has held a central yet conflicted role within the Western imagination ever since the first "discovery" of Indian religions by European scholars. Always radical, always extremely Other, Tantra has proven a key factor in the imagining of India. This book offers a critical account of how the phenomenon has come to be. Tracing the complex genealogy of Tantra as a category within the history of religions, Hugh B. Urban reveals how it has been formed through the interplay of popular and scholarly imaginations. Tantra emerges as a product of mirroring and misrepresentation at work between East and West--a dialectical category born out of the ongoing play between Western and Indian minds. Combining historical detail, textual analysis, popular cultural phenomena, and critical theory, this book shows Tantra as a shifting amalgam of fantasies, fears, and wish-fulfillment, at once native and Other, that strikes at the very heart of our constructions of the exotic Orient and the contemporary West. |
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910633982803321 |
|
|
Autore |
Centonze Giorgia |
|
|
Titolo |
Scaffold Protein p140Cap as a Molecular Hub for Limiting Cancer Progression : A New Paradigm in Neuroblastoma / / written by Giorgia Centonze [and eight others] |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
London : , : IntechOpen, , 2021 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (130 pages) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Nota di contenuto |
|
1. Introduction -- 2. The p140Cap adaptor protein -- 3. SRCIN1 mRNA expression is an independent prognostic marker for NB -- 4. p140Cap negatively affects tumorigenic features -- 5. Molecular mechanisms and therapeutic targets in neuroblastoma -- 6. p140Cap impairs the |
|
|
|
|
|
|
|
|
|
|
|
Src/p130Cas and the STAT3/Jak2 signaling pathways -- 7. p140Cap increases NB cell sensitivity to chemotherapeutic treatment -- 8. p140Cap increases NB cell sensitivity to Src kinase inhibitors -- 9. Conclusions -- Acknowledgments -- Conflict of interest -- Rights and permissions -- Abbreviations -- References. |
|
|
|
|
|
|
Sommario/riassunto |
|
Neuroblastoma, the most common extra-cranial pediatric solid tumor, is responsible for 9-15% of all pediatric cancer deaths. Its intrinsic heterogeneity makes it difficult to successfully treat, resulting in overall survival of 50% for half of the patients. Here we analyze the role in neuroblastoma of the adaptor protein p140Cap, encoded by the SRCIN1 gene. RNA-Seq profiles of a large cohort of neuroblastoma patients show that SRCIN1 mRNA levels are an independent risk factor inversely correlated to disease aggressiveness. In high-risk patients, SRCIN1 was frequently altered by hemizygous deletion, copy-neutral loss of heterozygosity, or disruption. Functional assays demonstrated that p140Cap is causal in dampening both Src and Jak2 kinase activation and STAT3 phosphorylation. Moreover, p140Cap expression decreases in vitro migration and anchorage-independent cell growth, and impairs in vivo tumor progression, in terms of tumor volume and number of spontaneous lung metastasis. p140Cap also contributes to an increased sensitivity of neuroblastoma cells to chemotherapy drugs and to the combined usage of doxorubicin and etoposide with Src inhibitors. Overall, we provide the first evidence that SRCIN1/p140Cap is a new independent prognostic marker for patient outcome and treatment, with a causal role in curbing the aggressiveness of neuroblastoma. We highlight the potential clinical impact of SRCIN1/p140Cap expression in neuroblastoma tumors, in terms of reducing cytotoxic effects of chemotherapy, one of the main issues for pediatric tumor treatment. |
|
|
|
|
|
|
|
| |