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1. |
Record Nr. |
UNINA9910447259503321 |
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Titolo |
Studies of epithelial transporters and ion channels : ion channels and transporters of epithelia in health and disease . Vol. 3 / / Kirk L. Hamilton, Daniel C. Devor, editors |
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Pubbl/distr/stampa |
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Cham, Switzerland : , : Springer : , : American Physiological Society, , 2020 |
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ISBN |
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Edizione |
[Second edition.] |
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Descrizione fisica |
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1 online resource (XXI, 1244 p. 256 illus., 203 illus. in color.) |
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Collana |
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Physiology in health and disease |
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Disciplina |
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Soggetti |
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Epithelium |
Epiteli |
Canals iònics |
Farmacologia |
Llibres electrònics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells -- 2. Na+-K+-2Cl- Cotransporter -- 3. Thiazide-sensitive NaCl Cotransporter -- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia -- 5. Na+/H+ Exchangers in Epithelia -- 6. Sugar Transport Across Epithelia -- 7. Amino Acid Transporters of Epithelia -- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX) -- 9. Urea Transporters in Health and Disease -- 10. H,K-ATPases in Epithelia -- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells -- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters -- 13. ClC-2 Chloride Channels -- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology -- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine -- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator -- 17. TMEM16 Proteins (Anoctamins) in Epithelia -- 18. Epithelial Sodium Channels (ENaC) -- 19. ROMK and Bartter Syndrome Type 2 -- 20. Inwardly-rectifying K+ |
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channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron -- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels -- 22. KCa3.1 in Epithelia -- 23. BK Channels in Epithelia -- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels -- 25. KCNE regulation of KCNQ channels -- 26. Orai Channels -- 27. Trp Channels in Renal Epithelia -- 28. P2X receptors in Epithelia -- 29. The Polycystins and Polycystic Kidney Disease -- 30. Renal Aquaporins in Health and Disease. |
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Sommario/riassunto |
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This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians. |
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2. |
Record Nr. |
UNINA9910300069203321 |
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Autore |
Celestin Louis-Cyril |
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Titolo |
Charles-Edouard Brown-Séquard : The Biography of a Tormented Genius / / by Louis-Cyril Celestin |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014 |
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ISBN |
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Edizione |
[1st ed. 2014.] |
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Descrizione fisica |
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1 online resource (279 p.) |
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Disciplina |
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Soggetti |
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Medicine—History |
Neurology |
History of Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Physiology in the Nineteenth Century -- The Birthplace -- The Forebears -- The Formative Years: 1817-1837 -- The Medical Student: 1838-1846 -- The Lone Experimenter: 1846-1851 -- The Visitor to America: 1852-1853 -- The Cholera Physician: 1854 -- The Richmond Professor: 1854-1855 -- The Paris Practitioner: 1856-1857 -- The Itinerant Lecturer: 1856-1859 -- The London Consultant Neurologist: 1860-1864 -- The Harvard Professor: 1864-1867 -- The Paris Course Lecturer: 1869-1872 -- The New York Practitioner: 1872-1874 -- The Indigent Physician: 1874-1877 -- The College de France Professor: 1878-1894 -- The Father of Hormonal Therapy: 1889-1893 -- The Last Years: 1892-1894. |
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Sommario/riassunto |
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Genius and dilettantism often go hand in hand. Nowhere is this truer than in the life of Charles-Edouard Brown-Séquard, the bilingual physician and neurologist who succeeded Claude Bernard as the Chair of Experimental Medicine at the College de France in Paris after having practiced in Paris, London and in the USA, especially in Harvard. For most men, making one discovery of global importance would have |
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sufficed to satisfy their curiosity and self-image. Not so Brown-Séquard. His explanation of the neurological disparity following the hemi-section of the spinal cord was a unique achievement that added his name to the syndrome and made him immortal. Yet, the demons of his mind tormented him in his endless search for medical truths and drove him to explore other phenomena, seeking to explain and remedy them. This unique biography shows for the first time the conflict between his professional and personal life, and should appeal to all students of medical history and psychology. |
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