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1. |
Record Nr. |
UNINA9910437992603321 |
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Titolo |
Advances in DNA repair in cancer therapy / / Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors |
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Pubbl/distr/stampa |
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New York, : Springer, 2013 |
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ISBN |
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1-283-93366-7 |
1-4614-4741-0 |
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Edizione |
[1st ed. 2013.] |
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Descrizione fisica |
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1 online resource (316 p.) |
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Collana |
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Cancer drug discovery and development |
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Altri autori (Persone) |
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PanasciLawrence |
AloyzRaquel |
Alaoui-JamaliMoulay |
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Disciplina |
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616.99 |
616.99/4061 |
616.99406 |
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Soggetti |
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Cancer - Treatment - Genetic aspects |
DNA repair |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Preface -- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy -- The role of BRCA1 and BRCA2 in anticancer drug therapy -- DNA-PK in CLL Chemotherapy -- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a Therapeutic Target -- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index. |
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Sommario/riassunto |
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This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The |
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DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined. |
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2. |
Record Nr. |
UNINA9910410014203321 |
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Titolo |
Educating Adolescents Around the Globe : Becoming Who You Are in a World Full of Expectations / / edited by Meike Watzlawik, Alina Burkholder |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (331 pages) |
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Collana |
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Cultural Psychology of Education, , 2364-6799 ; ; 11 |
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Disciplina |
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Soggetti |
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Educational psychology |
Developmental psychology |
International education |
Comparative education |
Educational sociology |
Educational Psychology |
Developmental Psychology |
International and Comparative Education |
Sociology of Education |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Part A: Adolescence from a Theoretical Perspective -- Ch.1 Adolescence - A Cultural-Sociological Perspective -- Ch.2 Adolescents Instead of Adolescence: Beyond Phases and Developmental Tasks -- Part B: A Journey to different Countries around the World -- Ch.3 |
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Educating Adolescents in India: Challenges and A Proposed Roadmap -- Ch.4 India’s Demographic Dividend: Addressing the Challenge of Poverty in Educating Adolescents -- Ch.5 Building Blocks and Barriers to Educational Attainment and Learning in Kenyan Schools: Preserving or Changing Cultural Identity Markers -- Ch.6 Education for Street-Connected Children in Kenya: Marginalization, Challenges, and Recommendations -- Ch.7 Is It Fair? The German Education System and Its Stumbling Blocks for Adolescents -- Ch.8 Dead End Schools? Refugee Teenagers and School Segregation in Germany -- Ch.9 The Brazilian Education System: The Challenges of Inequality -- Ch.10Teaching Young Offenders in Brazil -- Ch.11 Japanese Schools and (Necessary) Educational Reforms: Challenges and Opportunities for Adolescents -- Ch.12 The Dialogical Construction of School Connectedness for Delinquent Youth -- Ch.13 Generation Calm – When Education Turns Inward -- Ch.14 Contextualised Understanding of and Transdisciplinary Approaches to School Dropout -- Part C: Learning and Intervention -- Ch.15: What Is There to Be Learned and How? Learning Through the Lens of the Self -- Ch.16 School as Intervention: A Multilayered and Culturally Embedded Concept -- Ch.17 My delinquent voice: Screaming, but so what? -- Ch.18 A Tour of Adolescent Education around the World: Lessons Learned and A Vision for the Future. |
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Sommario/riassunto |
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By traveling to different parts of the world, this book provides a multidisciplinary perspective on the current state of adolescent education and demonstrates how education systems are formed by and closely tied to culture. After establishing a theoretical background, the book delves into the particulars of adolescent education and its associated challenges in six countries (India, Kenya, Germany, Brazil, Japan, and Denmark). In tandem with the discussion of institutions, the stories of those who are all too often underserved or left behind are told. Despite the diversity of each education system, the investigation reveals several unifying themes that transcend the specific contexts. The lessons from each example are woven together to demonstrate how the individualized needs of students can best be met, in a vision for the future of educating adolescents.". |
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