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1. |
Record Nr. |
UNINA9910437840803321 |
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Titolo |
Gadd45 Stress Sensor Genes / / edited by Dan A. Liebermann, Barbara Hoffman |
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Pubbl/distr/stampa |
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New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
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ISBN |
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Edizione |
[1st ed. 2013.] |
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Descrizione fisica |
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1 online resource (141 p.) |
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Collana |
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Advances in Experimental Medicine and Biology, , 0065-2598 ; ; 793 |
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Disciplina |
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Soggetti |
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Medical genetics |
Biochemistry |
Human genetics |
Gene Function |
Biochemistry, general |
Human Genetics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Gadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver — Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index. |
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Sommario/riassunto |
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Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, |
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inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved. . |
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2. |
Record Nr. |
UNINA9910157465303321 |
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Autore |
Fieschi C |
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Titolo |
Effects of Aging on Regulation of Cerebral Blood Flow and Metabolism : : 2nd Satellite Symposium, San Remo, June-July 1983 / / editors, C. Fieschi, G.L. Lenzi, C.W. Loeb |
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Pubbl/distr/stampa |
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Basel : , : S. Karger, , 1984 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (XIV + 258 pages) : : 99 figures, 51 tables |
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Collana |
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Soggetti |
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Neurology |
Gerontology / Geriatrics |
Neurosurgery |
Electroencephalogram |
Neuropathology |
Nuclear Medicine |
Pharmacology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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