1.

Record Nr.

UNINA9910437837103321

Autore

Smith Lee B

Titolo

Testosterone: From Basic Research to Clinical Applications / / by Lee B. Smith, Rod T. Mitchell, Iain J. McEwan

Pubbl/distr/stampa

New York, NY : , : Springer New York : , : Imprint : Springer, , 2013

ISBN

9781461489788

1461489784

Edizione

[1st ed. 2013.]

Descrizione fisica

1 online resource (78 p.) : illustrations (some color)

Collana

SpringerBriefs in Reproductive Biology, , 2194-4253

Disciplina

615.366

Soggetti

Testosterone

Endocrinology

Cytology

Testosterone - physiology

Testosterone - therapeutic use

Leydig Cells - metabolism

Receptors, Androgen - physiology

Androgens - therapeutic use

Reproductive Medicine

Cell Biology

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

History of Masculinization -- Recent Understanding of Masculinization -- Where Does Testosterone Come from and How Does It Act? -- Androgen Receptor Signaling in the Testis -- Androgen Signaling in Other Body Systems -- Manipulating Androgens for Therapy.

Sommario/riassunto

This volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of



testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.