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Record Nr. |
UNINA9910437837103321 |
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Autore |
Smith Lee B |
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Titolo |
Testosterone: From Basic Research to Clinical Applications / / by Lee B. Smith, Rod T. Mitchell, Iain J. McEwan |
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Pubbl/distr/stampa |
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New York, NY : , : Springer New York : , : Imprint : Springer, , 2013 |
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ISBN |
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Edizione |
[1st ed. 2013.] |
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Descrizione fisica |
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1 online resource (78 p.) |
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Collana |
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SpringerBriefs in Reproductive Biology, , 2194-4253 |
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Disciplina |
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Soggetti |
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Reproductive medicine |
Endocrinology |
Cell biology |
Reproductive Medicine |
Endocrinology |
Cell Biology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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""Preface""; ""Contents""; ""Abstract""; ""1 History of Masculinization""; ""1.1�From the Ancient World to the Nineteenth Century""; ""1.2��Cell Therapy� or the Search for �The Fountain of Youth�""; ""1.3�Steroid Hunters""; ""1.4�Dihydrotestosterone a Potent Androgen""; ""1.5�Receptor Model for Steroid Hormone Action""; ""1.6�Key Points-Summary""; ""References""; ""2 Recent Understanding of Masculinization""; ""2.1�The History of Masculinization""; ""2.2�The Ontogeny of Testicular Development"" |
""2.3�Human Conditions Associated with Androgen Disruption During Development""""2.4�The Universal Male Programming Window""; ""2.5�Key Points-Summary""; ""References""; ""3 Where Does Testosterone Come from and How Does It Act?""; ""3.1�Testes-Cellular Morphology""; ""3.2�Steroidogenesis""; ""3.3�Adrenal Gland""; ""3.4�Ovary""; ""3.5�The Androgen Receptor (NR3C4)""; ""3.5.1 Ligand Binding Domain""; ""3.5.2 DNA Binding Domain/Hinge Region""; ""3.5.3 N-Terminal Domain""; ""3.6�Rapid Signaling by Testosterone""; ""3.7�Key Points-Summary""; ""References"" |
""4 Androgen Receptor Signaling in the Testis""""4.1�Introduction""; |
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""4.2�Tfm ARKO Mouse""; ""4.3�The Cre/Lox System""; ""4.4�Cell-Specific KO""; ""4.5�AR in Sertoli Cells""; ""4.6�AR in Peritubular Myoid Cells""; ""4.7�AR in Leydig Cells""; ""4.8�Key Points-Summary""; ""References""; ""5 Androgen Signaling in Other Body Systems""; ""5.1�Seminal Vesicles""; ""5.2�Epididymis""; ""5.3�Prostate""; ""5.3.1 Androgens and Prostate Gland Development""; ""5.3.2 Prostate Cancer""; ""5.4�Muscle and Bone""; ""5.4.1 Bone""; ""5.4.2 Muscle Cells"" |
""5.4.3 Spinal Bulbular Muscular Dystrophy (SBMA Kennedy�s Disease)""; ""5.5�Cardiovascular Role of Testosterone""; ""5.6�Female Reproductive System""; ""5.6.1 Breast""; ""5.6.2 Endometrium""; ""5.7�Key Points-Summary""; ""References""; ""6 Manipulating Androgens for Therapy""; ""6.1�Management of DSD""; ""6.1.1 Congenital Adrenal Hyperplasia""; ""6.1.2 Androgen Insensitivity Syndrome""; ""6.1.3 5 alpha -Reductase Deficiency""; ""6.2�Delayed Puberty and Pubertal Induction""; ""6.3�Fertility Induction""; ""6.4�Erectile Dysfunction"" |
""6.5�Testosterone in the Aging Male: The �Andropause�""""6.6�Polycystic Ovarian Syndrome (PCOS)""; ""6.7�Key Points""; ""References""; ""Epilogue Future Perspectives "" |
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Sommario/riassunto |
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This volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit. |
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