| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910437834903321 |
|
|
Titolo |
Sodium calcium exchange : a growing spectrum of pathophysiological implications : proceedings of the 6th International Conference on Sodium Calcium Exchange / / Lucio Annunziato, editor |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
New York, : Springer, 2013 |
|
|
|
|
|
|
|
ISBN |
|
1-283-93368-3 |
1-4614-4756-9 |
|
|
|
|
|
|
|
|
Edizione |
[1st ed. 2013.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (456 p.) |
|
|
|
|
|
|
Collana |
|
Advances in experimental medicine and biology |
|
|
|
|
|
|
Altri autori (Persone) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Sodium channels |
Calcium channels |
Sodium cotransport systems |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and indexes. |
|
|
|
|
|
|
Nota di contenuto |
|
pt. I. Historical perspective -- pt. II. Structural and functional aspects of NCX -- pt. III. Structural and functional aspects of NCKX -- pt. IV. Genetic and epigenetic regulation -- pt. V. Regulatory mechanisms of NCX -- pt. VI. Subcellular localization and function of NCX in Ca[superscript 2+]-storing organelles and mitochondria -- pt. VII. NCX in neurodegenerative diseases -- pt. VIII. Emerging role of NCX activity in immune and glial cells -- pt. IX. NCX in the heart and vascular smooth muscle -- pt. X. NCX role in hypertension, heart failure, ischemia-reperfusion, arrhythmias and diabetes -- pt. XI. NCX partners in ionic homeostasis : ASIC, NMDA, NHE and TRPC. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic |
|
|
|
|
|
|
|
|
|
|
regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract. The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE. Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the “Federico II” University of Naples, Italy. He is coordinator of the University’s Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases. . |
|
|
|
|
|
| |